Meta-analysis evaluating the impact of chili-pepper intake on all-cause and cardiovascular mortality: A systematic review

Spicy foods and chili peppers contain the primary ingredient capsaicin, which has potential health benefits. However, their efficacy in some health outcomes is also fiercely disputed, and some side effects have been confirmed. To assess the quality and strength of the associations between spicy food and chili pepper consumption and different health outcomes. An umbrella review is performed in humans. Eleven systematic reviews and meta‐analyses with a total of 27 findings are identified. The health effect of consuming spicy food and chili peppers is unclear. Furthermore, the characteristics and context of different world regions and populations should be carefully considered. Direct correlations exist in esophageal cancer, gastric cancer, and gallbladder cancer. However, negative connections are reported in metabolism, mortality, and cardiovascular disease. Dose–response analysis reveals a significant nonlinear relationship between gastric cancer risk and capsaicin intake. The consumption of spicy foods and chili peppers is typically safe. However, high‐quality proof is available to confirm this conclusion.

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“…Dose–response analysis found a significant nonlinear relationship between GC risk and capsaicin intake ( p nonlinearity <0.05). [ 22 ]…”

Section: Resultsmentioning

confidence: 99%

Spicy Food and Chili Peppers and Multiple Health Outcomes: Umbrella Review

Huang

Liu

2022

Molecular Nutrition Food Res

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“…Recently, a dietary supplement derived from natural products has become an important approach to inhibit the establishment and progression of cardiovascular disease ( McChesney et al, 2007 , Alissa and Ferns, 2012 , Shen, 2015 , Waltenberger et al, 2016 , Asgary et al, 2018 , Trejo-Moreno et al, 2018 ). The cardioprotective effect (antioxidant, anti-inflammatory, lipid metabolism regulator) of onion, garlic, cucumber, white cabbage, chili, tomato, and basil leave have been studied for a long time( Rivlin et al, 2006 , Yang, 2018 , Rachmawati et al, 2019 , Yamani et al, 2021 ). Interestingly, many countries including Indonesia have traditional cuisine composed of mixed vegetable, herbs, and spices called sambal lalapan.…”

Section: Discussionmentioning

confidence: 99%

Metabolite profiling, hypolipidemic, and anti-atherosclerosis activity of mixed vegetable fermentation extract

Rachmawati¹,

Suharti²,

Sargowo³

et al. 2023

Saudi Pharmaceutical Journal

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“…The benefit of chili pepper consumption for prolonging healthspan and preventing cardio-vascular diseases was recently found but is still being debated. [5][6][7][8][9][10][11][12] It is tempting to test the effects of this spice on animal models as was previously done for other potential antiaging remedies. Moreover, capsaicin, a bioactive component of chili peppers, has already been found to prolong lifespan in female fruit flies, Drosophila melanogaster.…”

Section: Introductionmentioning

confidence: 99%