Mesoporous silica nanorods toward efficient loading and intracellular delivery of siRNA

Chen, Lijue; She, Xiaodong; Wang, Tao; Shigdar, Sarah; Duan, Wei; Kong, Lingxue

doi:10.1007/s11051-017-4115-0

Cited by 12 publications

(13 citation statements)

References 47 publications

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“…The current issues in the development of MSNs as drug carriers are the improvement of drug storage capacity and design of controlled- and targeted-drug release. In order to improve the drug storage capacity of MSNs, various shapes of MSN nanostructures are developed, such as spherical shape, ,,− nanocubes, rodlike nanostructures, − hollow nanostructures, − and so forth. The current finding demonstrates that the hollow nanostructure of MSNs has high drug storage capacity because of the presence of a hollow interior devoted to entrap a large quantity of drugs.…”

Section: Introductionmentioning

confidence: 99%

pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

et al. 2020

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In the current report, hollow mesoporous silica (HMS) nanoparticles were successfully prepared by means of a hard-templating method and further modified with poly(styrene sulfonate) (PSS) via radical polymerization. Structural analysis, surface spectroscopy, and thermogravimetric characterization confirmed a successful surface modification of HMS nanoparticles. A hairy PSS was clearly visualized by high-resolution transmission electron microscopy measurement, and it is grown on the surface of HMS nanoparticles. The Brunauer− Emmett−Teller surface area and average pore size of HMS nanoparticles were reduced after surface modification because of the pore-blocking effect, which indicated that the PSS lies on the surface of nanoparticles. Nevertheless, the PSS acts as a "nano-gate" to control the release of curcumin which is triggered by pH. The drug-release profile of unmodified HMS nanoparticles showed a stormed release in both pH 7.4 and 5.0 of phosphate buffer saline buffer solution. However, a slow release (9.92% of cumulative release) of curcumin was observed at pH 7.4 when the surface of HMS nanoparticles was modified by PSS. The kinetic release study showed that the curcumin release mechanism from PSS@HMS nanoparticles followed the Ritger−Peppas kinetic model, which is the non-Fickian diffusion. Therefore, the PSS-decorated HMS nanoparticles demonstrate potential for pH-triggered drug release transport.

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Section: Introductionmentioning

confidence: 99%

pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

et al. 2020

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“…Study results showed an improved concentration of siRNA in the colorectal cancer cells, and it caused surviving gene knock down to be less than 30%. 169 3.3. Combinational Drug Delivery.…”

Section: Application Of Silica Nanoparticles In Cancer Targetingmentioning

confidence: 99%

Tuning Mesoporous Silica Nanoparticles in Novel Avenues of Cancer Therapy

et al. 2022

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The global menace of cancer has led to an increased death toll in recent years. The constant evolution of cancer therapeutics with novel delivery systems has paved the way for translation of innovative therapeutics from bench to bedside. This review explains the significance of mesoporous silica nanoparticles (MSNs) as delivery vehicles with particular emphasis on cancer therapy, including novel opportunities for biomimetic therapeutics and vaccine delivery. Parameters governing MSN synthesis, therapeutic agent loading characteristics, along with tuning of MSN toward cancer cell specificity have been explained. The advent of MSN in nanotheranostics and its potential in forming nanocomposites for imaging purposes have been illustrated. Additionally, various hurdles encountered during the bench to bedside translation have been explained along with potential avenues to circumvent them. This also opens up new horizons in drug delivery, which could be useful to researchers in the years to come.

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“…When compared to non-targeted nanoparticles, FA-modified silica nanoparticles showed increased cytotoxicity in both human cervical and breast cancer cells and tumour absorption [ 98 , 99 , 100 ]. MSNs are employed in nucleic acid-guided treatments and nucleic acid delivery because of their relatively large surface area, superior biocompatibility for functionalization and variable pore size used to encapsulate various cargos [ 101 , 102 , 103 , 104 ].…”

Section: Nanocarriers Used In Cancer Therapymentioning

confidence: 99%

Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review

et al. 2021

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Cancer is a group of disorders characterized by uncontrolled cell growth that affects around 11 million people each year globally. Nanocarrier-based systems are extensively used in cancer imaging, diagnostics as well as therapeutics; owing to their promising features and potential to augment therapeutic efficacy. The focal point of research remains to develop new-fangled smart nanocarriers that can selectively respond to cancer-specific conditions and deliver medications to target cells efficiently. Nanocarriers deliver loaded therapeutic cargos to the tumour site either in a passive or active mode, with the least drug elimination from the drug delivery systems. This review chiefly focuses on current advances allied to smart nanocarriers such as dendrimers, liposomes, mesoporous silica nanoparticles, quantum dots, micelles, superparamagnetic iron-oxide nanoparticles, gold nanoparticles and carbon nanotubes, to list a few. Exhaustive discussion on crucial topics like drug targeting, surface decorated smart-nanocarriers and stimuli-responsive cancer nanotherapeutics responding to temperature, enzyme, pH and redox stimuli have been covered.

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Mesoporous silica nanorods toward efficient loading and intracellular delivery of siRNA

Cited by 12 publications

References 47 publications

pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

Tuning Mesoporous Silica Nanoparticles in Novel Avenues of Cancer Therapy

Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review

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