Mesoporous silica decorated with gold nanoparticles as a promising nanoprobe for effective CT X-ray attenuation and potential drug delivery

Mulikova, Tomiris; Abduraimova, Aiganym; Molkenova, Anara; Em, Svetlana; Duisenbayeva, Bakyt; Han, Dong‐Wook; Atabaev, Timur Sh.

doi:10.1016/j.nanoso.2021.100712

Cited by 21 publications

(9 citation statements)

References 21 publications

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“…This modification of CS will have consequences in changing CSNPs properties, specialty drug release. CSNPs have shown great potential with extensive use in active substance administration, diagnostics, and other sectoral uses [ 20 ], including personal medicine [ 21 ]. These advances raise questions about the safety of NPs.…”

Section: Introductionmentioning

confidence: 99%

Drug release study of the chitosan-based nanoparticles

Herdiana

Wathoni

Shamsuddin

et al. 2022

Heliyon

205

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Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted drug delivery, and controlled drug release. Chitosan-based drug nanoparticles (CSNPs) systems are employed as diagnostic imaging and delivering the drug to particular targeted sites in a regulated manner. Drug release is an important factor in ensuring high reproducibility, stability, quality control of CSNPs, and scientific-based for developing CSNPs. Several factors influence drug release from CSNPs, including composition, composition ratio, ingredient interactions, and preparation methods. Early, CSNPs were used for improving drug solubility, stability, pharmacokinetics, and pharmacotherapeutics properties. Chitosan has been developed toward a multifunctional drug delivery system by exploring positively charged properties and modifiable functional groups. Various modifications to the polymer backbone, charge, or functional groups will undoubtedly affect the drug release from CSNPs. The drug release from CSNPs has a significant influence on its therapeutic actions. Our review's objective was to summarize and discuss the relationship between the modification in CSNPs as multifunctional delivery systems and drug release properties and kinetics of the drug release model. Kinetic models help describe the release rate, leading to increased efficiency, accuracy, the safety of the dose, optimizing the drug delivery device's design, evaluating the drug release rate, and improvement of patient compatibility. In conclusion, almost all CSNPs showed bi-phasic release, initial burst release drug in a particular time followed controlled manner release in achieving the expected release, stimuli external can be applied. CSNPs are a promising technique for multifunctional drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Drug release study of the chitosan-based nanoparticles

Herdiana

Wathoni

Shamsuddin

et al. 2022

Heliyon

205

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“…Similarly in another study, gemcitabine-loadedalbumin nanospheres effectively decreased the proliferation and stimulated the apoptosis of human pancreatic cancer cells without causing any side effects when compared to the individual compound; thus, albumin nanospheres can acts as potential candidates to stimulate the anticancer effect of gemcitabine [ 115 ]. In a study, mesoporous silica decorated with gold nanoparticles exerted very high X-ray attenuation efficiency ~9.8 HU/mM in CT and also can be used as a effective vehicle for drug delivery [ 116 ]. In another study, mesoporous silica-coated gold nanorods loaded DOX induces toxicity in the breast cancer cells (MCF-7) and also decreased tumor growth in xenograft mice and ultimately suggested that nanoparticle could be an efficient drug delivering agent and also increases local heat at the tumor site and thus exhibited higher combined therapeutic potential [ 117 ].…”

Section: Types Of Nanoparticlesmentioning

confidence: 99%

Broad-Spectrum Theranostics and Biomedical Application of Functionalized Nanomaterials

Alshamrani

2022

Polymers

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Nanotechnology is an important branch of science in therapies known as “nanomedicine” and is the junction of various fields such as material science, chemistry, biology, physics, and optics. Nanomaterials are in the range between 1 and 100 nm in size and provide a large surface area to volume ratio; thus, they can be used for various diseases, including cardiovascular diseases, cancer, bacterial infections, and diabetes. Nanoparticles play a crucial role in therapy as they can enhance the accumulation and release of pharmacological agents, improve targeted delivery and ultimately decrease the intensity of drug side effects. In this review, we discussthe types of nanomaterials that have various biomedical applications. Biomolecules that are often conjugated with nanoparticles are proteins, peptides, DNA, and lipids, which can enhance biocompatibility, stability, and solubility. In this review, we focus on bioconjugation and nanoparticles and also discuss different types of nanoparticles including micelles, liposomes, carbon nanotubes, nanospheres, dendrimers, quantum dots, and metallic nanoparticles and their crucial role in various diseases and clinical applications. Additionally, we review the use of nanomaterials for bio-imaging, drug delivery, biosensing tissue engineering, medical devices, and immunoassays. Understandingthe characteristics and properties of nanoparticles and their interactions with the biological system can help us to develop novel strategies for the treatment, prevention, and diagnosis of many diseases including cancer, pulmonary diseases, etc. In this present review, the importance of various kinds of nanoparticles and their biomedical applications are discussed in much detail.

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“…To date, a broad range of nanomaterials has been developed for these imaging techniques, many of which offer notable advantages over conventional molecular methods. These nanomaterials include superparamagnetic iron oxide nanoparticles (SPIONs) approved by FDA for MRI contrast acquisition [ 229 ], gold nanoparticles used for CT [ 230 , 231 , 232 ], and inorganic semiconducting NPs, such as quantum dots (QDs) or upconverting nanoparticles (UCNPs) used for narrow and tunable emission spectra in optical imaging [ 233 , 234 , 235 , 236 ]. However, some drawbacks of these imaging agents, such as difficulties in surface modification and physiological instability upon in vivo administration, need to be overcome.…”

Section: Update On Msn Applications In Nanomedicinesmentioning

confidence: 99%

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

et al. 2021

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The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications.

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Mesoporous silica decorated with gold nanoparticles as a promising nanoprobe for effective CT X-ray attenuation and potential drug delivery

Cited by 21 publications

References 21 publications

Drug release study of the chitosan-based nanoparticles

Drug release study of the chitosan-based nanoparticles

Broad-Spectrum Theranostics and Biomedical Application of Functionalized Nanomaterials

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

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