Mesoporous Si‐MCM‐41/Polymer as a pH‐Responsive Drug Delivery System for Cancer Therapy

Maghsoudi, Mina; Abbasian, Mojtaba; Farhadi, Khalil; Mahmoodzadeh, Farideh; Ghorbani, Marjan; Hoseinzadeh, Mehdi

doi:10.1002/slct.202002071

Cited by 7 publications

(6 citation statements)

References 31 publications

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“…At pH 4.0 (Figures 7b and 8B), all of the investigated nanocarriers exhibited increased release of Dox, which was expected due to its known better solubility in acidic media [54,55]. Such acidic conditions are expected for tumour cells because of their extensive metabolism [56]. The pristine MCM-41 loaded with Dox at pH = 4.0 showed a significant release with some burst effect in the first 6 h of dissolution (47.3 ±.…”

Section: Drug Releasementioning

confidence: 80%

Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

Voycheva,

Slavkova,

Popova

et al. 2023

Preprint

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Hydrogels can offer many opportunities for drug delivery strategies. They can be used on their own or their benefits can be further exploited in combination with other nanocarriers. Intelligent hydrogels that react to changes in the surrounding environment can be utilized as gatekeepers and provide sustained on demand drug release. In this study, a hybrid nanosystem for tempera-ture and pH sensitive delivery was prepared from MCM-41 nanoparticles grafted with newly synthesized thermosensitive hydrogel (MCM-41/AA-g-PnVCL). The initial particles were chemi-cally modified by carboxyl groups attachment. Later, they were grafted with agar (AA) and vi-nylcaprolactam (VCL) by free radical polymerization. Doxorubicin was applied as a model hy-drophilic chemotherapeutic drug. The successful formulation was confirmed by FT-IR and TGA. Transmission electron microscopy and dynamic light scattering analysis showed small particles with negative zeta potential. Their release behaviour was investigated in vitro in different pH media and at different temperatures. At tumor simulating conditions (40ºC and pH 4.0) doxoru-bicin was almost completely released within 72 hours. The biocompatibility of the proposed na-noparticles was demonstrated by in vitro haemolysis assay. These results suggest the possible parenteral application of the newly prepared hydrogel-functionalized mesoporous silica nanopar-ticles for temperature-sensitive and pH-triggered drug delivery at the tumor site.

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Section: Drug Releasementioning

confidence: 80%

Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

Voycheva,

Slavkova,

Popova

et al. 2023

Preprint

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show abstract

Section: Resultsmentioning

confidence: 99%

“…Since our systems are intended to be used for peroral administration, we performed dissolution studies in standard media with pH 1.2 and 6.8. A medium with pH 5 was chosen to simulate the environmental conditions in tumor cells (see Table 3) [62]. As a cationic drug (pKa = 8.3), DOX release from all the samples was faster into media with pH 1.2 and pH 5.0 (lower T 50 values) compared to pH 6.8 [62,63].…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Doxorubicin and Quercetin Double Loading in Modified MCM-41 Lowered Cardiotoxicity in H9c2 Cardioblast Cells In Vitro

et al. 2023

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Background: One of the therapeutic limitations of the use of doxorubicin (DOX) as an anticancer drug is its cardiotoxicity. Its hydrophilicity also causes difficulties in achieving sustained release. The simultaneous delivery with the well-known natural antioxidant quercetin could ameliorate its cardiotoxicity. Thus, the main aim of this work is to study the potential of carboxylated and non-carboxylated mesoporous silica MCM-41 nanoparticles for double loading of the hydrophilic doxorubicin hydrochloride and hydrophobic quercetin (Q) in one nanocarrier with a modified release pattern to reduce the cardiotoxic side effects of doxorubicin in vitro. Methods: The methods included the modification of MCM-41, single and double loading of modified and non-modified MCM-41, physicochemical characterization, in vitro release tests and kinetic study, and in vitro cell viability studies. Results: Doxorubicin and quercetin were successfully double-loaded with encapsulation efficiency (EE) of 43 ± 4.1% and 37 ± 4.5%, respectively, in native MCM-41. The post-synthetic carboxylation led to 49 ± 4.3% EE (DOX) and 36 ± 4.0% (Q) and double lowering of the cardiotoxicity on H9c2 (IC50 = 5.96 µm). Sustained release profiles over 72 h were achieved. Conclusions: A successful procedure was proposed for the efficient double loading of a hydrophilic drug and a hydrophobic drug. The carboxy-modified double-loaded nanosystems demonstrate a decreased in vitro cardiotoxicity of doxorubicin and can be considered as a potential chemotherapeutic formulation.

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“…At pH 4.0 ( Figure 7 b and Figure 8 B), all of the investigated nanocarriers exhibited increased release of Dox, which was expected due to its known better solubility in acidic media [ 54 , 55 ]. Such acidic conditions are expected for tumour cells because of their extensive metabolism [ 56 ]. The pristine MCM-41 loaded with Dox at pH = 4.0 showed a significant release with some burst effect in the first 6 h of dissolution (47.3 ±.…”

Section: Resultsmentioning

confidence: 99%

Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

Voycheva,

Slavkova,

Popova

et al. 2023

Gels

View full text Add to dashboard Cite

Hydrogels can offer many opportunities for drug delivery strategies. They can be used on their own, or their benefits can be further exploited in combination with other nanocarriers. Intelligent hydrogels that react to changes in the surrounding environment can be utilized as gatekeepers and provide sustained on-demand drug release. In this study, a hybrid nanosystem for temperature- and pH-sensitive delivery was prepared from MCM-41 nanoparticles grafted with a newly synthesized thermosensitive hydrogel (MCM-41/AA-g-PnVCL). The initial particles were chemically modified by the attachment of carboxyl groups. Later, they were grafted with agar (AA) and vinylcaprolactam (VCL) by free radical polymerization. Doxorubicin was applied as a model hydrophilic chemotherapeutic drug. The successful formulation was confirmed by FT-IR and TGA. Transmission electron microscopy and dynamic light scattering analysis showed small particles with negative zeta potential. Their release behaviour was investigated in vitro in media with different pH and at different temperatures. Under tumour simulating conditions (40 °C and pH 4.0), doxorubicin was almost completely released within 72 h. The biocompatibility of the proposed nanoparticles was demonstrated by in vitro haemolysis assay. These results suggest the possible parenteral application of the newly prepared hydrogel-functionalized mesoporous silica nanoparticles for temperature-sensitive and pH-triggered drug delivery at the tumour site.

show abstract

Mesoporous Si‐MCM‐41/Polymer as a pH‐Responsive Drug Delivery System for Cancer Therapy

Cited by 7 publications

References 31 publications

Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

Doxorubicin and Quercetin Double Loading in Modified MCM-41 Lowered Cardiotoxicity in H9c2 Cardioblast Cells In Vitro

Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

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