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Nano-controlled drug delivery systems such as polymer nanocomposites introduce new strategies for the cancer prevention, diagnosis and treatment. In this study, we designed a biocompatible polymer Nanocomposites (NCs) based on modified mobil composition of matter No. 41 (MCM-41) nanoparticles (MCM-41-NH 2) and copolymer grafted chitosan by acrylamide and acrylic acid (CS-graft-poly (AAm-co-AA) as a pHsensitive polymer, and employed for targeted anticancer drug delivery. Doxorubicin (DOX) is a potent drug for cancer therapy. DOX was loaded into the synthesized polymer NCs MCM-41-NH 2-CS-graft-poly (AAm-co-AA) by formation electrostatic attraction between the positive charge of the DOX and the anionic charge of the poly acrylic acid (PAA), and poly acrylamide (PAAm). Free DOX diffuse rapidly into nucleus, and kill cancerous cells by interaction with deoxyribonucleic acid (DNA). But, keeping active of free anticancer drugs after reaching at the nucleus is difficult due to the bio barriers. Using DOX-loaded into the mentioned polymer NCs can be decreased the toxicity effects (side effects) of DOX on the normal cells and enhance its efficiency on the tumorous cells The release of DOX from the MCM-41-NH 2-CS-g-poly (AAm-co-AA) was studied at acidic conditions (on the human breast epithelial adenocarcinoma (MCF-7) cancer cells, pH 5.3 and 40°C). The cytotoxicity of the DOX loaded into MCM-41-NH 2-CS-g-poly (AAm-co-AA) on the (MCF-7) cancer cells was evaluated by using MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidefor). The results show that synthetic mesoporous Si-MCM-41/ polymer can act as a targeted drug delivery system for the treatment of MCF-7 cancerous cell.

A novel chitosan–based nanocomposite containing mesoporous nanosilica MCM-41 was synthesized, and its application as a good adsorbent for Pb (II) ions was investigated. In this context, MCM-41 was modified by 3-(Triethoxysilyl)-propylamine (3-APTES) to prepare MCM-41-NH2, and then MCM-41-NH2-graft-polyarcrylamide-co-polyacrylic acide-graft-chitosan [(MCM-41-NH2-g-poly(AAm-co-AA)-g-CS] nanocomposite was fabricated by in situ polymerization. The morphology and structure of nanocomposite were characterized by FT-IR, FE-SEM, EDS, XRD, AAS and TGA analysis. The results exhibited that active functional groups such as (-NH2) and (-COOH) on the nanocomposite surface reacted with Pb (II) ions via coordination bond. Maximum Pb (II) ion removal was seen at pH (6). The Pb (II) concentration and reaction time were 60 mg L−1 and 75 min as optimum conditions. Kinetics studies exhibited that adsorption experimental data were well adjusted to Langmuir isotherm, and the adsorption process onto polymer followed the pseudo-second order kinetics. As a result, it is expected that the synthesized nanocomposite can provide a promising prospect in the field of wastewater treatment.