Mesojejunoileac Liposarcoma with Intrahepatic Metastasis in a Dog

Abstract

ABSTRACT. We report a liposarcoma at the mesojejunoileum that was widely excised, and then the intrahepatic metastatic liposarcoma was found. The dog was treated by two single-agent chemotherapy separately. The patient was an 8-year-old, male Dachshund, and was referred to our hospital owing to the significant distention of the left abdomen. Neither radiography nor ultrasonography detected the actual association of the tumor with the abdominal viscera before surgery. A large-sized tumor mass that adhered to the mesojejunoileum was explored by laparatomy. Final diagnosis of a pleomorphic liposarcoma was made by the routine histology and further identified by Oil Red O stain. The two single-agent chemotherapy including doxorubicin followed by capecitabine, however, failed to cause remission of the intrahepatic metastatic lesions. The patient died 22 months after operation and the cause of death was supposed to be metastatic liposarcoma. KEY WORDS: chemotherapy, liposarcoma, metastasis.J. Vet. Med. Sci. 70(6): 637-640, 2008 Liposarcomas occurred primarily in appendicular or axial locations, and extracutaneous development of liposarcomas was rare in dogs [1,3,4,10]. Liposarcoma tends to be aggressive, locally invasive and may metastasize to lung, liver, spleen and bone [1,5]. They are locally invasive neoplasms that rarely metastasized, and wide excision is preferred to marginal excision [1]. However, the usefulness of chemotherapy in liposarcomas has rarely evaluated [7]. To our knowledge, liposarcoma developed in the mesojejunoileum has not been reported in veterinary literature.A male Dachshund, eight-year-old, was referred to our hospital owing to enlargement of the abdomen, predominately on the left side. He was obese and weighed 11.6 kg. Two months earlier, both radiography and ultrasonography performed at an animal clinic and presumed a large-sized mass associated with the spleen. The patient had a history of gradual distention of the left abdomen, and the intermittent anorexia, vomiting, difficulty at defecation, and occasional listlessness. There was a palpable firmness and painless mass within the abdomen.Lateral radiographs displayed that the mass was within ventrally cranial to middle abdomen, dorsal displacement of stomach and intestines, and caudal displacement of intestines. The ventrodorsal radiograph showed that this mass was located within the left abdomen, and superimposed on the left kidney, and that caused cranial displacement of stomach and medial displacement of intestines (Fig. 1). Distant metastatic lesions were not found by thoracic radiographs. Ultrasonography (USG) revealed that this tumor mass had a feature of a mixed echogenicity, which was within the left abdomen and located caudal to the liver and in front of urinary bladder, and enlarged regional lymph nodes were not found. The mass was measured as 12-cm in maximum diameter.Routinely hematological examination revealed a moderate normocytic, normochromic anemia (hematocrit, 22.5% and hemoglobin, 7.2 g m/dL) with two nucleated RBC i...

Comparisons Among Computed Tomographic Features of Adipose Masses in Dogs and Cats

“…Liposarcomas have been further classified into subtypes based on cellular morphology, however the different histological appearances do not correspond to differences in biological behavior in domestic animals . Although liposarcomas generally show a low metastatic potential, they are characterized by local invasion and high recurrence rate …”

Liposarcoma in animals

“…22,59 The lack of cytokeratin labeling is useful in differentiating liposarcomas from other lipid-rich neoplasias, such as mesotheliomas. 16,42 The histological staining reviewed in the literature of veterinary liposarcomas include oil red O, 7,9,12,14,16,18,29,30,45,46,49,52,66 periodic acid-Schiff, 1,34 osmium tetroxide, 18,45,52 alcian blue, and toluidine. 17,45 The immunohistochemical markers most frequently used were vimentin, 1,14,16,42,43,47,52,59,65 S100, 1,16,42,47,59,65 cytokeratin, 1,16,42,43,47,50,52,59,65 CD3, 51 actin,…”

“…44 The first choice of treatment for human beings and animals is a wide surgical excision, the current established treatment for soft tissue sarcoma. 26 Although used in combination in some contexts to control recurrence, 7 the efficacy of radiation therapy and chemotherapy remains uncertain at this time. 26…”

“…7,52 Mitoses are frequent. 7,22,52 This tumor mimics other pleomorphic mesenchymal malignancies, especially when they have scant lipoblasts. 67 Liposarcomas resemble a pleomorphic variant of histiocytic sarcoma but, in the case of liposarcomas, they lack significant collagenous stroma and spindle-cell popu-lation.…”

Liposarcoma of the spermatic cord in a Toy Poodle

“…Liposarcomas in dogs are uncommon soft tissue tumors that consist of lipoblasts and mesenchymal tissue. They can develop in any tissue that contains fat cells, including subcutaneous tissues, body cavities, and other extracutaneous tissues, and tend to be locally invasive [ 2 , 4 , 7 , 8 , 18 ]. To our knowledge, liposarcoma of the spermatic cord (LSC) is extremely rare in both dogs and humans, with approximately only 200 cases in humans being reported worldwide [ 5 , 11 , 14 , 15 , 16 ].…”