Mesial temporal sclerosis

Deshpande, Sheetal; Kashyap, Prashant; Dave, Dhaval; Mukherji, Anannya

doi:10.18203/2320-6012.ijrms20163826

Cited by 2 publications

(5 citation statements)

References 8 publications

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“…Mesial temporal sclerosis is the scarring of the medial temporal lobes of the brain. It is recognized as the most common pathologic finding in the temporal lobe epilepsy [ 20 ]. The underlying mechanism of MTS development in seizure is explained through prolonged neuronal depolarization caused by the release of excitatory amino acids.…”

Section: Discussionmentioning

confidence: 99%

“…Consequent to the cellular damage, scar tissue forms especially in hippocampus, a region of temporal lobe. This process is followed by atrophy [ 20 ]. MRI is the imaging of choice for evaluation of MTS, since it is a noninvasive modality and unveils the localization of deficits and structural abnormalities to a great extent [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Mesial temporal sclerosis is the scarring of the medial temporal lobes of the brain. It is recognized as the most common pathologic finding in the temporal lobe epilepsy [20] ronal depolarization caused by the release of excitatory amino acids. As a result, an influx of cytotoxic amounts of calcium occurs, which eventually leads to sclerosis [20].…”

Section: Discussionmentioning

confidence: 99%

“…It is recognized as the most common pathologic finding in the temporal lobe epilepsy [20] ronal depolarization caused by the release of excitatory amino acids. As a result, an influx of cytotoxic amounts of calcium occurs, which eventually leads to sclerosis [20]. Therefore, if the seizures last longer, the development of MTS is more likely [21].…”

Section: Discussionmentioning

confidence: 99%

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New MRI Finding in Migraineurs: Mesial Temporal Sclerosis

2019

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Background:Based on our experience, a noticeable number of migraineurs without history of epilepsy disclose mesial temporal sclerosis (MTS) on their brain MRI. This prospective study was conducted to assess the frequency of MTS in migraineurs and also determine the ratio of unilateral and bilateral cases.Material and Methods: The frequency of MTS in MRI of 84 migraine patients, who had symptoms for at least 2 years, assessed. Brain MRI was done with T1 and T2 weighted protocols. Two radiologists separately interpreted findings, defining MTS as presence of any of hippocampal atrophy, increased T2 signal of hippocampus, decreased T1 signal of hippocampus or loss of internal architecture. Patients who radiologists had not agreement on their diagnoses excluded. Stat analysis done using ‘N - 1’ chi squared test.Results: Eleven patients were excluded due to non-accordant interpretation of MRI findings by the two examining radiologists. MTS was detected in 14 out of 73 patients (19%). Bilateral involvement of mesial temporal lobe was seen in 6 (8%) patients (M: 67%, F: 33%). Five cases (7%) had unilateral left MTS (M: 67%, F: 33%) while 3 (4%) were affected with right-sided MTS (M: 33%, F: 67%). These findings highly suggest association of MTS and Migraine (P-value <0.0001).Conclusion: While MTS is a prevalent finding in migraineurs, incidental finding of MTS in MRI should suspect physicians of migraine as well as temporal lobe epilepsy. MTS can be proposed as an etiology of migraine but most likely, consequence of it.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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New MRI Finding in Migraineurs: Mesial Temporal Sclerosis

2019

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“…It seemed that generalized seizures were converted to complex partial ones by involvement of hippocampus, but the conversion is under question with unreliable patient's memory. Notable atrophy of hippocampus in various MRI cuts with widening of Sylvian fissure, distention of the left lateral ventricle, and loss of normal architecture of hippocampus in the left side were suggesting mesial temporal sclerosis (MTS), the most common cause of drug resistant epilepsy (7). Main causes of MTS are traumatic brain injury, inflammatory process, eg, infections and recurrent seizure.…”

Section: Discussionmentioning

confidence: 99%

Complex Partial Seizure and Hippocampus Atrophy Caused by Tramadol Abuse: A Case Study

Ahmadi

Hoseinzade

Haghighi

et al. 2017

Ann Mil Health Sci Res

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Generalized seizure is known as a dose-independent side effect of tramadol. The presented case is affected by complex partial seizures, following tramadol dependency. Brain magnetic imaging showed atrophy of left hippocampus, compatible with mesial temporal sclerosis. Mesial temporal sclerosis is the most common cause of treatment-resistant seizure with etiology of trauma, inflammatory processes, and recurrent seizures. It seems that recurrent generalized seizure by tramadol abuse is responsible for hippocampus atrophy, mesial temporal sclerosis, and complex partial seizures.

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Mesial temporal sclerosis

Cited by 2 publications

References 8 publications

New MRI Finding in Migraineurs: Mesial Temporal Sclerosis

New MRI Finding in Migraineurs: Mesial Temporal Sclerosis

Complex Partial Seizure and Hippocampus Atrophy Caused by Tramadol Abuse: A Case Study

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