Mesenchymal Stem/Progenitor Cells and Their Derivates in Tissue Regeneration

Abstract

Mesenchymal stem/stromal cells (MSC) have been extensively studied over the last 30 years in the context of their regenerative and immunomodulatory activities for potential application in regenerative medicine [...]

Mesenchymal Stem Cell Microvesicles from Adipose Tissue: Unraveling Their Impact on Primary Ovarian Cancer Cells and Their Therapeutic Opportunities

“…Isolated MSCs play an important role in regenerative medicine due to their increased proliferative activity and survival, anti-inflammatory potential, and modulation of the immune system [13]. Moreover, MSCs also release various bioactive molecules in the form of soluble factors, EVs, exosomes, and microvesicles (MVs), which act in the tissue microenvironment as mediators of cell-to-cell communication by exerting paracrine effects [14,15]. It is well documented that MSCs are recruited to the tumor site, and the tropism of MSCs to tumors has been used as the basis of cancer cytotherapy [12].…”

Telocytes and Other Interstitial Cells 2.0: From Structure to Function

“…In the cell biology of interstitial cells, a new heterogenous distinctive population was described in recent years under the name of "telocytes" [1]. In the diverse landscape of cellular components found in the interstitial space, there are distinct populations that can be grouped according to the functions they perform in: (a) cells with a supporting role, also acting as immune regulators, e.g., fibroblastic reticular cells [2]; (b) cells with a role in the synthesis of extracellular matrix components, e.g., fibroblasts [3]; (c) stem/progenitor cells, e.g., mesenchymal cells [4]; (d) mechanochemical sensors or stem cell nurses, e.g., telocytes [5]; (e) cells with pacemaker properties, e.g., interstitial cells of Cajal [6], to mention but a few principal categories. This Special Issue, titled "Telocytes and Other Interstitial Cells 2.0: From Structure to Function", represents the continuation of a previous issue, reflecting the importance of these cells in the field of intestinal cell research [7].…”