iPSCs-derived mesenchymal stromal cells mitigate anxiety and neuroinflammation in aging female mice

Wei, Xu; Li, Ruijie; Li, Xiangyu; Wang, Boyan; Huang, Jianyang; Mu, Hanyiqi; Zhang, Qinmu; Zhang, Ziyuan; Ru, Yifei; Wu, Xinxiang; Qiu, Yuan; Ye, Yanchen; Yan, Feng; Wang, Shiyu; Chen, Hui; Yi, Chenju; Wang, Jiancheng

doi:10.1016/j.biocel.2022.106347

Cited by 4 publications

(4 citation statements)

References 46 publications

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“…In conclusion, a significant decrease in estrogen levels disrupts immune homeostasis, particularly the levels of the immune factors TNF-α, IL-1β, IL-4, IL-6, IL-10 and IL-18 through the ERα/ERβ/GPER-associated NLRP3/ NF-κB signaling pathway, which involves many signaling molecules, such as TLR2, TLR4, P2X7R, SIRT1, CREB, MS-KIF18A, PI3K, AKT, Gs, cAMP, PKA, PJA1, Exerted the antidepressant-like effects by regulating the levels of IL-1β, IL-6 and TNF-α in the hippocampus [163] Chaihu-Guizhi-Ganjiang tang Unclear Perimenopausal and postmenopausal women with mood disorder Reduced plasma IL-6 and soluble IL-6 receptor concentrations and improved depressed mood [164] PR, progesterone receptor; AR, androgenic receptor Serpina3n, Src, and MMP-9 [19-24, 41, 43, 44, 47-49, 52, 54-56, 58]. Subsequently, the increase of inflammatory cytokine levels causes BBB destruction [25,[62][63][64][65][66][67][68][69][70][71][72][73][74]165], the dysfunction of neurotransmitters such as 5-HT [80][81][82][83][84][85], DA [86][87][88][89][90][91][92][93][94][95][96][97], NE [98][99][100][101]…”

Section: Discussionmentioning

confidence: 99%

“…In the brain tissue of menopausal women or animal models, a decrease in estrogen levels caused an increase in the number of M1 microglia and activated astrocytes, which can secrete a large number of inflammatory cytokines. Therefore, inflammatory cytokines may play an important role in changes in BBB permeability [25,[64][65][66][67][68][69][70][71][72][73][74]. Several subsequent studies have demonstrated that TNF-α, IL-6 and IL-17 can reduce the expression of claudin-5, zona occludens-1 (ZO-1) and other tight junction proteins by activating NF-κB signaling pathways in endothelial cells, destroying the structure of the BBB and promoting depressive behavior [69,70].…”

Section: Bbb Destructionmentioning

confidence: 99%

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Estrogen-immuno-neuromodulation disorders in menopausal depression

Zhang,

Tan,

Tang

2024

J Neuroinflammation

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A significant decrease in estrogen levels puts menopausal women at high risk for major depression, which remains difficult to cure despite its relatively clear etiology. With the discovery of abnormally elevated inflammation in menopausal depressed women, immune imbalance has become a novel focus in the study of menopausal depression. In this paper, we examined the characteristics and possible mechanisms of immune imbalance caused by decreased estrogen levels during menopause and found that estrogen deficiency disrupted immune homeostasis, especially the levels of inflammatory cytokines through the ERα/ERβ/GPER-associated NLRP3/NF-κB signaling pathways. We also analyzed the destruction of the blood-brain barrier, dysfunction of neurotransmitters, blockade of BDNF synthesis, and attenuation of neuroplasticity caused by inflammatory cytokine activity, and investigated estrogen-immuno-neuromodulation disorders in menopausal depression. Current research suggests that drugs targeting inflammatory cytokines and NLRP3/NF-κB signaling molecules are promising for restoring homeostasis of the estrogen-immuno-neuromodulation system and may play a positive role in the intervention and treatment of menopausal depression.

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Section: Discussionmentioning

confidence: 99%

Section: Bbb Destructionmentioning

confidence: 99%

Estrogen-immuno-neuromodulation disorders in menopausal depression

Zhang,

Tan,

Tang

2024

J Neuroinflammation

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“…Wei et al differentiated mesenchymal stromal cells from human iPSCs and drugged mice with them. It resulted in improved BBB integrity and decreased inflammation in the mice’s CNS (Wei et al 2023 ).…”

Section: In Vitro Bbb Modelsmentioning

confidence: 99%

The Progress in Molecular Transport and Therapeutic Development in Human Blood–Brain Barrier Models in Neurological Disorders

Korszun-Karbowniczak,

Krysiak,

Saluk

et al. 2024

Cell Mol Neurobiol

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The blood–brain barrier (BBB) is responsible for maintaining homeostasis within the central nervous system (CNS). Depending on its permeability, certain substances can penetrate the brain, while others are restricted in their passage. Therefore, the knowledge about BBB structure and function is essential for understanding physiological and pathological brain processes. Consequently, the functional models can serve as a key to help reveal this unknown. There are many in vitro models available to study molecular mechanisms that occur in the barrier. Brain endothelial cells grown in culture are commonly used to modeling the BBB. Current BBB platforms include: monolayer platforms, transwell, matrigel, spheroidal, and tissue-on-chip models. In this paper, the BBB structure, molecular characteristic, as well as its dysfunctions as a consequence of aging, neurodegeneration, or under hypoxia and neurotoxic conditions are presented. Furthermore, the current modelling strategies that can be used to study BBB for the purpose of further drugs development that may reach CNS are also described.

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“…transplanted human iPSC-derived MSC into white rabbits with cartilage defects, and cartilage-like tissues were observed in the experimental group at 6 weeks, indicating that iPSCs may repair cartilage defects in vivo [ 159 ]. Recent studies have shown that iPSC-derived MSC alleviate anxiety and neuroinflammation in aging female mice, which may provide a new option for treating hormone disorders and neurological diseases related to perimenopause in the female aging process [ 160 ]. In addition to this, clinical research on MSCs derived from iPSC is also underway.…”

Section: Advancements In Msc Therapiesmentioning

confidence: 99%

Current state of stem cell research in non-human primates: an overview

Wu,

Shi,

Yang

et al. 2023

Medical Review

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The remarkable similarity between non-human primates (NHPs) and humans establishes them as essential models for understanding human biology and diseases, as well as for developing novel therapeutic strategies, thereby providing more comprehensive reference data for clinical treatment. Pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells provide unprecedented opportunities for cell therapies against intractable diseases and injuries. As continue to harness the potential of these biotechnological therapies, NHPs are increasingly being employed in preclinical trials, serving as a pivotal tool to evaluate the safety and efficacy of these interventions. Here, we review the recent advancements in the fundamental research of stem cells and the progress made in studies involving NHPs.

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iPSCs-derived mesenchymal stromal cells mitigate anxiety and neuroinflammation in aging female mice

Cited by 4 publications

References 46 publications

Estrogen-immuno-neuromodulation disorders in menopausal depression

Estrogen-immuno-neuromodulation disorders in menopausal depression

The Progress in Molecular Transport and Therapeutic Development in Human Blood–Brain Barrier Models in Neurological Disorders

Current state of stem cell research in non-human primates: an overview

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