Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

Cosenza, Stella; Ruiz, Maxime; Toupet, Karine; Jørgensen, Christian; Noël, Danièle

doi:10.1038/s41598-017-15376-8

Cited by 449 publications

(428 citation statements)

References 33 publications

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“…The therapeutic effect of MSC‐derived exosomes on arthritis have also been investigated. In several studies, intravenous or intra‐articular exosomes isolated from MSCs were shown to inhibit macrophage activation, inflammation, and cartilage destruction in in vitro and in vivo models via inhibition of catabolisis, inflammatory markers and apoptosis, increase of collagen type II synthesis, and modulation of T and B cells …”

Section: Role Of Exosomesmentioning

confidence: 99%

Exosomes in Inflammation and Inflammatory Disease

et al. 2019

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Exosomes are a subset of extracellular vesicles released by all cell types and involved in local and systemic intercellular communication. In the past decade, research into exosomes has swelled as their important role in the mediation of health and disease has been increasingly established and acknowledged. Exosomes carry a diverse range of cargo including proteins, nucleic acids, and lipids derived from their parental cell that, when delivered to the recipient cell, can confer pathogenic or therapeutic effects through modulation of immunity and inflammation. In this review, the role of exosomes on mediation of immune and inflammatory responses, and their participation in diseases with a significant inflammatory component is discussed. The considerable potential for exosomes in therapy and diagnosis of inflammatory diseases is also highlighted.

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Section: Role Of Exosomesmentioning

confidence: 99%

Exosomes in Inflammation and Inflammatory Disease

et al. 2019

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“…Extracellular vesicle (EV), including exosomes, may also be a novel therapeutic option for OA. Studies in small animal OA models showed that stem cell derived EVs attenuated OA disease progression in vitro and in vivo by displaying similar biological functions as stem cells; however, further investigations into the mechanism is required before application to the clinic . These are exciting times for stem cell biology, both in the lab and the clinic, to help in the understanding and management of OA.…”

Section: Mscs Acsc Ips Cells: What Is the Best Practical Stem Cellmentioning

confidence: 99%

Stem cell-directed therapies for osteoarthritis: The promise and the practice

Little

Woods

et al. 2020

Stem Cells

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Osteoarthritis (OA) is a disease of an entire synovial joint characterized by clinical symptoms and distortion of joint tissues, including cartilage, muscles, ligaments, and bone. Although OA is a disease of all joint tissues, it is a defined accessible compartment and is thus amenable to topical surgical and regenerative therapies, including stem cells. All tissues arise from stem progenitor cells, and the relative capacity of different cellular compartments, and different individuals, to renew tissues into adulthood may be important in the onset of many different degenerative diseases. OA is driven by both mechanical and inflammatory factors, but how these factors affect the proliferation and differentiation of cells into cartilage in vivo is largely unknown. Indeed, our very basic understanding of the physiological cellular kinetics and biology of the stem‐progenitor cell unit of the articular cartilage, and how this is influenced by mechano‐inflammatory injury, is largely unknown. OA seems, rather deceptively, to be the low‐hanging fruit for stem cell therapy. Without the basic understanding of the stem cell and progenitor unit that generate and maintain articular cartilage in vivo, we will continue to waste opportunities to both prevent and manage this disease. In this review, we discuss the biology of chondrogenesis, the stem cell populations that support articular cartilage in health and disease, and future opportunities afforded through the translation of basic articular chondrocyte stem cell biology into new clinical therapies.

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“…Clinical and animal studies demonstrated the efficacy of MSC therapies and the importance of MSC paracrine secretion in various diseases [27,28]. Cosenza et al injected MSC-derived exosomes into a collagenase-induced OA model and found that it protected mice from joint damage [29]. Zhang et al investigated if intra-articular injection of human embryonic MSC-derived exosomes repaired and regenerated osteochondral defects in a rat model [30].…”

Section: Therapeutic Potential Of Exosomes In Joint Diseasesmentioning

confidence: 99%

Emerging Role of Exosomes in the Joint Diseases

Zeng

Wang

et al. 2018

Cell Physiol Biochem

104

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Exosomes are a subset of small, membrane-bound extracellular vesicles that are important for communication among cells. They originate from the cell membrane during endocytic internalization, and are stable in biological fluids, including blood and synovial fluids. Increasing knowledge is emerging about exosomes in joint diseases, including osteoarthritis, rheumatoid arthritis, osteonecrosis of the femoral head, and others. Exosomes in synovial fluid can lead to inflammation, degeneration of cartilage, and destruction of joints. Exosomes in blood have diagnostic value in the early disease stage or for complicated conditions of joint diseases. Exosomes from stem cells could delay diseases and repair joints. For a comprehensive understanding about the emerging role of exosomes in joint diseases, we introduced the isolation and verification of exosomes from synovial fluid, reviewed the physiological and pathological effects of exosomes on joints, and discussed the diagnostic value and therapeutic potential of exosomes in joint diseases. In the future, immunologically active exosomes and engineered exosomes will of interest in the joint diseases. Challenges in the field of exosomes in joint-disease research include complex and expensive isolation, detection of contributing molecular, effectiveness and safety evaluation. In summary, challenges remain, but the field of exosomes in joint diseases has potential, including in mechanisms, diagnoses and therapies.

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Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

Cited by 449 publications

References 33 publications

Exosomes in Inflammation and Inflammatory Disease

Exosomes in Inflammation and Inflammatory Disease

Stem cell-directed therapies for osteoarthritis: The promise and the practice

Emerging Role of Exosomes in the Joint Diseases

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