Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

Lin, Zhengjun; Wu, Yanlin; Xu, Yiting; Li, Guoqing; Li, Zhihong; Liu, Tang

doi:10.1186/s12943-022-01650-5

Cited by 97 publications

(60 citation statements)

References 156 publications

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“…EV can be obtained from a variety of specimens, including cell culture supernatants and various body fluids, such as blood and urine ( Logozzi et al, 2020 ). MSC-derived EV play an increasingly important role in intracellular communication and tissue repair ( Joo et al, 2020 ; Lin et al, 2022 ). Compared with living cells, their clinical application may offer significant advantages because they may reduce adverse side effects after application, as well as infusion toxicity, uncontrolled cell growth, and possible tumor formation ( Liang et al, 2014 ; Qiu et al, 2019 ; Weng et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Human umbilical cord mesenchymal stem cells derived extracellular vesicles alleviate salpingitis by promoting M1–to–M2 transformation

Zhang

Liao²,

Li³

et al. 2023

Front. Physiol.

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Background: With an increasing number of patients experiencing infertility due to chronic salpingitis after Chlamydia trachomatis (CT) infection, there is an unmet need for tissue repair or regeneration therapies. Treatment with human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hucMSC-EV) provides an attractive cell-free therapeutic approach.Methods: In this study, we investigated the alleviating effect of hucMSC-EV on tubal inflammatory infertility caused by CT using in vivo animal experiments. Furthermore, we examined the effect of hucMSC-EV on inducing macrophage polarization to explore the molecular mechanism.Results: Our results showed that tubal inflammatory infertility caused by Chlamydia infection was significantly alleviated in the hucMSC-EV treatment group compared with the control group. Further mechanistic experiments showed that the application of hucMSC-EV induced macrophage polarization from the M1 to the M2 type via the NF-κB signaling pathway, improved the local inflammatory microenvironment of fallopian tubes and inhibited tube inflammation.Conclusion: We conclude that this approach represents a promising cell-free avenue to ameliorate infertility due to chronic salpingitis.

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Section: Discussionmentioning

confidence: 99%

Human umbilical cord mesenchymal stem cells derived extracellular vesicles alleviate salpingitis by promoting M1–to–M2 transformation

Zhang

Liao²,

Li³

et al. 2023

Front. Physiol.

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“…EMT weakens the strong adhesion between differentiated epithelial cells, allowing cancer cells to achieve individual or collective motility, which makes EMT an intuitive mechanism for tumor metastasis initiation (107)(108)(109). Exosomes can be involved in the EMT effect of tumor cells (110)(111)(112).…”

Section: Role Of Exosomes In Nsclc Metastasismentioning

confidence: 99%

Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

Rao

Huang

et al. 2023

Front. Immunol.

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As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes are widely present in various body fluids, and therefore they can be used as a potential tool for non-invasive liquid biopsy. The present study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). By targeting epidermal growth factor receptor (EGFR) therapy as a first-line treatment for patients with NSCLC, this study also briefly describes the occurrence of EGRF+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.

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“…Multiple lines of research have so far indicated that MSC-Exos are involved in a multitude of mechanisms that could lead to either the promotion or attenuation of cancer treatment resistance. It has been found that the MSC-Exos could enhance therapeutic sensitivity in several cancers, including lymphoma, breast cancer ovarian cancer, gastric cancer, and hepatocellular carcinoma [ 121 ]. Mechanistically, MSC-Exos hinder the development of these cancers through the inhibition of tumor proliferation and angiogenic pathways, and through the stimulation of apoptosis.…”

Section: Molecular Mechanisms Of Exosomesmentioning

confidence: 99%

Frontier Review of the Molecular Mechanisms and Current Approaches of Stem Cell-Derived Exosomes

Chen

Kao

Chen

et al. 2023

Cells

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Exosomes are effective therapeutic vehicles that may transport their substances across cells. They are shown to possess the capacity to affect cell proliferation, migration, anti-apoptosis, anti-scarring, and angiogenesis, via the action of transporting molecular components. Possessing immense potential in regenerative medicine, exosomes, especially stem cell-derived exosomes, have the advantages of low immunogenicity, minimal invasiveness, and broad clinical applicability. Exosome biodistribution and pharmacokinetics may be altered, in response to recent advancements in technology, for the purpose of treating particular illnesses. Yet, prior to clinical application, it is crucial to ascertain the ideal dose and any potential negative consequences of an exosome. This review focuses on the therapeutic potential of stem cell-derived exosomes and further illustrates the molecular mechanisms that underpin their potential in musculoskeletal regeneration, wound healing, female infertility, cardiac recovery, immunomodulation, neurological disease, and metabolic regulation. In addition, we provide a summary of the currently effective techniques for isolating exosomes, and describe the innovations in biomaterials that improve the efficacy of exosome-based treatments. Overall, this paper provides an updated overview of the biological factors found in stem cell-derived exosomes, as well as potential targets for future cell-free therapeutic applications.

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Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

Cited by 97 publications

References 156 publications

Human umbilical cord mesenchymal stem cells derived extracellular vesicles alleviate salpingitis by promoting M1–to–M2 transformation

Human umbilical cord mesenchymal stem cells derived extracellular vesicles alleviate salpingitis by promoting M1–to–M2 transformation

Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

Frontier Review of the Molecular Mechanisms and Current Approaches of Stem Cell-Derived Exosomes

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