Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

Rao, Dingyu; Huang, Defa; Si, Mao-Yan; Liu, Hua; Tang, Zhixian; Zhang, Zuxiong

doi:10.3389/fimmu.2023.1142539

Cited by 8 publications

(3 citation statements)

References 161 publications

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“…From the discovery of immunotherapy, with a single drug or in combination, a new era against cancer started. As explained for hematological malignancies, also in solid tumors immune checkpoint inhibitors, directed, for example, against programmed death protein-1 or the cytotoxic T lymphocyte antigen 4, are suitable permitting the reaching, in some cases, of superior results in terms of overall survival [49][50][51][52][53][54][55][56][57][58][59]. Oxidative stress, as is well known, has a pivotal role in cancerogenesis, in particular, the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) pathway is involved in chemoresistance in lung cancer through a stimulus to proliferation; in fact, an overexpression of HO-1 is related to higher tumor aggressivity [60].…”

Section: Lung Cancermentioning

confidence: 99%

Gender Differences and miRNAs Expression in Cancer: Implications on Prognosis and Susceptibility

Caserta

Gangemi

Murdaca

et al. 2023

IJMS

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MicroRNAs are small, noncoding molecules of about twenty-two nucleotides with crucial roles in both healthy and pathological cells. Their expression depends not only on genetic factors, but also on epigenetic mechanisms like genomic imprinting and inactivation of X chromosome in females that influence in a sex-dependent manner onset, progression, and response to therapy of different diseases like cancer. There is evidence of a correlation between miRNAs, sex, and cancer both in solid tumors and in hematological malignancies; as an example, in lymphomas, with a prevalence rate higher in men than women, miR-142 is “silenced” because of its hypermethylation by DNA methyltransferase-1 and it is blocked in its normal activity of regulating the migration of the cell. This condition corresponds in clinical practice with a more aggressive tumor. In addition, cancer treatment can have advantages from the evaluation of miRNAs expression; in fact, therapy with estrogens in hepatocellular carcinoma determines an upregulation of the oncosuppressors miR-26a, miR-92, and miR-122 and, consequently, apoptosis. The aim of this review is to present an exhaustive collection of scientific data about the possible role of sex differences on the expression of miRNAs and the mechanisms through which miRNAs influence cancerogenesis, autophagy, and apoptosis of cells from diverse types of tumors.

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Section: Lung Cancermentioning

confidence: 99%

Gender Differences and miRNAs Expression in Cancer: Implications on Prognosis and Susceptibility

Caserta

Gangemi

Murdaca

et al. 2023

IJMS

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“…Exosomes can be efficiently detected in a variety of body fluids and contain genetic information associated with tumors, providing a non-invasive method to gain genetic insights into disease. Their use in liquid biopsy can facilitate early detection of tumors, contribute to early diagnosis, and assist in clinical treatment, potentially improving the prognosis and quality of life of lung cancer patients ( 88 ). In addition, exosomal protein and nucleic acid markers are important for early diagnosis and prognosis of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Zhong,

Zhao,

Zhang

et al. 2024

Front. Oncol.

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BackgroundLung cancer, characterized by its high morbidity and lethality, necessitates thorough research to enhance our understanding of its pathogenesis and discover novel therapeutic approaches. Recent studies increasingly demonstrate that lung cancer cells can modulate the tumor microenvironment, promoting tumor growth, and metastasis through the release of exosomes. Exosomes are small vesicles secreted by cells and contain a variety of bioactive molecules such as proteins, nucleic acids, and metabolites. This paper presents a comprehensive review of exosome research in lung cancer and its progress through bibliometric analysis.MethodsPublications related to exosomes in lung cancer patients were systematically searched on the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was performed using VOSviwers, CiteSpace, and the R package “Bibliometrics”. Publications were quantitatively analyzed using Microsoft Office Excel 2019. The language of publication was restricted to “English” and the search strategy employed TS=(exosomes or exosomes or exosomes) and TS=(lung cancer). The search period commenced on January 1, 2004, and concluded on November 12, 2023, at noon. The selected literature types included Articles and Reviews.ResultsThe study encompassed 1699 papers from 521 journals across 71 countries and 2105 institutions. Analysis revealed a consistent upward trend in lung cancer exosome research over the years, with a notable surge in recent times. This surge indicates a growing interest and depth of inquiry into lung cancer exosomes. Major research institutions in China and the United States, including Nanjing Medical University, Shanghai Jiao Tong University, Chinese Academy Of Sciences, and Utmd Anderson Cancer Center, emerged as crucial research hubs. The annual publication count in this field witnessed a continuous rise, particularly in recent years. Key terms such as lung cancer, non-small cell lung cancer (NSCLC), microvesicles, intercellular communication, exosomal miRNAs, and oncology dominated the research landscape. Fields like cell biology, biochemistry, biotechnology, and oncology exhibited close relation with this research. Clotilde Théry emerged as the most cited author in the field, underlining her significant contributions. These results demonstrate the broad impact of exosome research in lung cancer, with key terms covering not only disease-specific aspects such as lung cancer and NSCLC but also basic biological concepts like microvesicles and intercellular communication. Explorations into exosomal microRNAs and oncology have opened new avenues for lung cancer exosome research. In summary, lung cancer exosome research is poised to continue receiving attention, potentially leading to breakthroughs in treatment and prevention.ConclusionPublications on lung cancer exosomes show a rising trend year by year, with China and the United States ranking first and second in terms of the number of publications. However, there is insufficient academic learning cooperation and exchanges between the two sides, and Chinese universities account for a large proportion of research institutions in this field. Jing Li is the most productive author, Clotilde Théry is the most co-cited author, and Cancers is the journal with the highest number of publications. The current focus in the field of lung cancer exosomes is on biomarkers, liquid biopsies, immunotherapy, and tumor microenvironment.

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“…Moreover, exosomes contain microRNAs, proteins, and other biomolecules which reflect the physiological state and pathological characteristics of secretory cells. The use of exosomes as biomarkers is a promising approach in the era of liquid biopsy, especially in NSCLC ( 88 ) and glioma ( 89 ).…”

Section: Application Of Vps4 In Carcinomamentioning

confidence: 99%

The role of Vps4 in cancer development

et al. 2023

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VPS4 series proteins play a crucial role in the endosomal sorting complexes required for the transport (ESCRT) pathway, which is responsible for sorting and trafficking cellular proteins and is involved in various cellular processes, including cytokinesis, membrane repair, and viral budding. VPS4 proteins are ATPases that mediate the final steps of membrane fission and protein sorting as part of the ESCRT machinery. They disassemble ESCRT-III filaments, which are vital for forming multivesicular bodies (MVBs) and the release of intraluminal vesicles (ILVs), ultimately leading to the sorting and degradation of various cellular proteins, including those involved in cancer development and progression. Recent studies have shown a potential relationship between VPS4 series proteins and cancer. Evidence suggests that these proteins may have crucial roles in cancer development and progression. Several experiments have explored the association between VPS4 and different types of cancer, including gastrointestinal and reproductive system tumors, providing insight into the underlying mechanisms. Understanding the structure and function of VPS4 series proteins is critical in assessing their potential role in cancer. The evidence supporting the involvement of VPS4 series proteins in cancer provides a promising avenue for future research and therapeutic development. However, further researches are necessary to fully understand the mechanisms underlying the relationship between VPS4 series proteins and cancer and to develop effective strategies for targeting these proteins in cancer therapy. This article aims to review the structures and functions of VPS4 series proteins and the previous experiments to analyze the relationship between VPS4 series proteins and cancer.

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Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

Cited by 8 publications

References 161 publications

Gender Differences and miRNAs Expression in Cancer: Implications on Prognosis and Susceptibility

Gender Differences and miRNAs Expression in Cancer: Implications on Prognosis and Susceptibility

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

The role of Vps4 in cancer development

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