Mesenchymal stem cell-derived exosomes as a bioinspired nanoscale tool toward next-generation cell-free treatment

Asadi, Kamran; Amini, Abbas; Gholami, Ahmad

doi:10.1016/j.jddst.2022.103856

Cited by 2 publications

(2 citation statements)

References 78 publications

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“…Exosome-based systems should be included under the designations “investigative medicinal products” (Europe) and “investigative new drugs” (US) [ 103 ]. Regarding the characterization and quality control of exosome-based products, the ISEV offers useful guidelines and explanations regarding 1) nomenclature, 2) exosome collection and pre-treatment, 3) exosome separation and purification, 4) exosome characterization, and 5) recommendations on functional studies to be performed [ 22 ].…”

Section: Clinical Translation and Regulationmentioning

confidence: 99%

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

Lopes¹,

Lopes²,

Pereira-Silva³

et al. 2023

Military Med Res

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A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes, such as natural cell membranes or subcellular structure-derived membranes. This strategy endows cloaked nanomaterials with improved interfacial properties, superior cell targeting, immune evasion potential, and prolonged duration of systemic circulation. Here, we summarize recent advances in the production and application of exosomal membrane-coated nanomaterials. The structure, properties, and manner in which exosomes communicate with cells are first reviewed. This is followed by a discussion of the types of exosomes and their fabrication methods. We then discuss the applications of biomimetic exosomes and membrane-cloaked nanocarriers in tissue engineering, regenerative medicine, imaging, and the treatment of neurodegenerative diseases. Finally, we appraise the current challenges associated with the clinical translation of biomimetic exosomal membrane-surface-engineered nanovehicles and evaluate the future of this technology.

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Section: Clinical Translation and Regulationmentioning

confidence: 99%

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

Lopes¹,

Lopes²,

Pereira-Silva³

et al. 2023

Military Med Res

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“…In recent times, nanomaterials have become noteworthy in the pharmaceutical area and precision oncology due to improved pharmacokinetics by specified drug delivery systems (DDSs), modified profile release and absorption, enhanced drug bioavailability, drug plasma consistency, real-time imaging, minimal complications, and finally, treatment according to molecular features of the target tissue ( Asadi and Gholami, 2021 ; Asadi et al, 2022 ). Among all the nanomaterials, hydrogels based on natural polymer with three-dimensional (3D) polymeric networks, a soft, biocompatible nature, and the ability to mimic the breast tissue microenvironment have received increased attention in cancer diagnostics and treatment.…”

Section: Introductionmentioning

confidence: 99%

Stimuli-responsive hydrogel based on natural polymers for breast cancer

Asadi,

Samiraninezhad,

Akbarizadeh

et al. 2024

Front. Chem.

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Aims: Breast cancer is the most common malignancy among women in both high- and low-resource settings. Conventional breast cancer therapies were inefficient and had low patient compliance. Stimuli-responsive hydrogels possessing similar physicochemical features as soft tissue facilitate diagnostic and therapeutic approaches for breast cancer subtypes.Scope: Polysaccharides and polypeptides are major natural polymers with unique biocompatibility, biodegradability, and feasible modification approaches utilized frequently for hydrogel fabrication. Alternating the natural polymer-based hydrogel properties in response to external stimuli such as pH, temperature, light, ultrasonic, enzyme, glucose, magnetic, redox, and electric have provided great potential for the evolution of novel drug delivery systems (DDSs) and various advanced technologies in medical applications. Stimuli-responsive hydrogels are triggered by specific cancer tissue features, promote target delivery techniques, and modify release therapeutic agents at localized sites. This narrative review presented innovation in preparing and characterizing the most common stimuli-responsive natural polymer-based hydrogels for diagnostic and therapeutic applications in the breast cancer area.Conclusion: Stimuli-responsive hydrogels display bioinspiration products as DDSs for breast cancer subtypes, protect the shape of breast tissue, provide modified drug release, enhance therapeutic efficacy, and minimize chemotherapy agents’ side effects. The potential benefits of smart natural polymer-based hydrogels make them an exciting area of practice for breast cancer diagnosis and treatment.

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Mesenchymal stem cell-derived exosomes as a bioinspired nanoscale tool toward next-generation cell-free treatment

Cited by 2 publications

References 78 publications

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

Stimuli-responsive hydrogel based on natural polymers for breast cancer

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