Merozoite surface protein 2 adsorbed onto acetalated dextran microparticles for malaria vaccination

Stiepel, Rebeca T.; Batty, Cole J.; MacRaild, Christopher A.; Norton, Raymond S.; Bachelder, Eric M.; Ainslie, Kristy M.

doi:10.1016/j.ijpharm.2020.120168

Cited by 11 publications

(6 citation statements)

References 34 publications

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“…Thus, flexible control can be achieved by Ace-DEX, which serves as a great tool in vaccine delivery. A new formulation of vaccine malaria was investigated in merozoite surface protein 2 (MSP2) antigen using Ace-DEX MPs as a vaccine excipient and alum as an adjuvant [ 111 ]. This formulation was demonstrated in a promising malaria vaccine via Th1-biased response, indicating high anti-inflammatory responses towards malaria infection.…”

Section: Microbe-based Polymersmentioning

confidence: 99%

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Nordin

Husna

Ahmad

et al. 2023

Gels

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A key element in ensuring successful immunization is the efficient delivery of vaccines. However, poor immunogenicity and adverse inflammatory immunogenic reactions make the establishment of an efficient vaccine delivery method a challenging task. The delivery of vaccines has been performed via a variety of delivery methods, including natural-polymer-based carriers that are relatively biocompatible and have low toxicity. The incorporation of adjuvants or antigens into biomaterial-based immunizations has demonstrated better immune response than formulations that just contain the antigen. This system may enable antigen-mediated immunogenicity and shelter and transport the cargo vaccine or antigen to the appropriate target organ. In this regard, this work reviews the recent applications of natural polymer composites from different sources, such as animals, plants, and microbes, in vaccine delivery systems.

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Section: Microbe-based Polymersmentioning

confidence: 99%

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Nordin

Husna

Ahmad

et al. 2023

Gels

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“…Recently, acetylated dextran microparticles have been considered for antigen uptake, and then this suitable platform has been applied as a malaria vaccine. Dextran nanoparticles can evoke Th1-biased responses to counteract intracellular pathogens . Acetalated dextran microparticles are another proposed platform as an influenza vaccine in which the antigen and adjuvant are loaded.…”

Section: Biodegradable Platforms In Vaccine Deliverymentioning

confidence: 99%

“…Dextran nanoparticles can evoke Th1-biased responses to counteract intracellular pathogens. 43 Acetalated dextran microparticles are another proposed platform as an influenza vaccine in which the antigen and adjuvant are loaded. This system provides beneficial protection against the flu because it not only increases the production of antibodies but also increases the cellular response.…”

Section: Biodegradable Platforms In Vaccine Deliverymentioning

confidence: 99%

Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers

Malek-Khatabi

Tabandeh

Nouri

et al. 2022

ACS Appl. Bio Mater.

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Biodegradable polymers are largely employed in the biomedical field, ranging from tissue regeneration to drug/vaccine delivery. The biodegradable polymers are highly biocompatible and possess negligible toxicity. In addition, biomaterial-based vaccines possess adjuvant properties, thereby enhancing immune responses. This Review introduces the use of different biodegradable polymers and their degradation mechanism. Different kinds of vaccines, as well as the interaction between the carriers with the immune system, then are highlighted. Natural and synthetic biodegradable micro-/nanoplatforms, hydrogels, and scaffolds for local or targeted and controlled vaccine release are subsequently discussed.

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“…54 In a recent study, the potential malaria vaccine antigen Merozoite surface protein 2 (MSP2) along with the acetalated dextran (Ac-DEX microparticles) was capable of eliciting both antibody-mediated (IgG response) and cellular immune response (Th1 response) when compared to alum adjuvant. 55 Similarly, Ac-DEX microparticles that are stable at pH 7 were capable of enhancing the cellular uptake (by cross-presentation) of the melioidosis subunit antigen through phagocytosis in APCs (where the pH is 5), as they are degradable in an acid environment. The microparticle has been reported to elicit a strong antibody response against Burkholderia pseudomallei by both Th1 and Th2 immune pathways 56 when administered to mice through the intraperitoneal route.…”

Section: Macromolecular Researchmentioning

confidence: 99%

Biopolymers and Osmolytes — A Focus towards the Prospects of Stability and Adjuvanticity of Vaccines

2022

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‘New-Gen Vaccines’ are grabbing the attention of scientists as they are much suitable for an immune-compromised group of individuals as well as infants. The major drawbacks of these vaccines are lower immunogenicity and instability. The need for a convenient and safe adjuvant is still under exploration. On the other hand, thermal instability leads to the inactivation of the vaccine and becomes detrimental in many cases. Thus, there is a need to incorporate new kinds of excipients into vaccine formulation to enhance the potency/immunogenicity of vaccine antigens and also act as stabilizers. A limited or single excipient in providing the required dual-activity is vital to break the stereotypical usage of the well-entrenched adverse ingredients. In the proposed review, the efficiency of naturally occurring biocompatible carbohydrate polymers and osmolytes and their ‘dual-role’ is briefed. In addition, the information on the possible mechanisms of action of carbohydrate polymers in vaccines as adjuvants and stabilizers are also discussed.

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Merozoite surface protein 2 adsorbed onto acetalated dextran microparticles for malaria vaccination

Cited by 11 publications

References 34 publications

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers

Biopolymers and Osmolytes — A Focus towards the Prospects of Stability and Adjuvanticity of Vaccines

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