Merkel Cell Carcinoma Presenting as Lymphadenopathy Without a Primary Cutaneous Lesion: A Report of 2 Cases

Neuroendocrine Merkel cell nodal carcinoma of unknown primary site: Management and outcomes of a rare entity

“…A significant proportion of MCCUP patients (12.2%, 11/90) had a history of a previously or concurrent treated malignancy (eight basal cell carcinomas, one prostate cancer, three patients with chronic lymphocytic leukaemia), two patients were transplant recipients and another three patients were carriers of HIV. In the immunosupressed population an earlier median onset of the disease at 52 years (37-61) was observed [3,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Almost all evaluable patients presented with clinically palpable non-tender lymph nodes-IIIB disease.…”

“…Inguinal and axillary lymph node areas were initially involved in 40% (36/90) and 17.7% (16/90) of cases, respectively. Lesions ranged in colour from red, pink to blue of flesh-coloured, sometimes with a shiny surface which may mislead to a basal cell carcinoma diagnosis [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Characteristics of all patients are summarised in Table 1 and are displayed in details in Table 2.…”

A Practical Update of Surgical Management of Merkel Cell Carcinoma of the Skin

“…In addition, mucosal MCC had been reported, for example, nasal mucosa and nasopharynx [27]. Occasionally 12% (38/321) of patients can present as nodal mass without any obvious primary in the skin [28, 29]. …”

Primary retroperitoneal Merkel cell carcinoma: Case report and literature review

“…It is estimated that 97.6% of MCC cases occur in the skin and 0.4% occur in other locations [23] . MCC has been reported in the lips and oral cavity [24] , parotid gland [25] , and lymph nodes [26] , [27] , [28] , [29] . Only 2% of all cases present without a primary site [20] .…”