Neuroendocrine Merkel cell nodal carcinoma of unknown primary site: Management and outcomes of a rare entity

Κοττέας, Ηλίας; Pavlidis, Nicholas

doi:10.1016/j.critrevonc.2014.12.005

Cited by 25 publications

(29 citation statements)

References 35 publications

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“…Merkel cell carcinoma (MCC) represents a rare skin cancer associated with sun exposure affecting mainly Caucasian males over the 6th decade [1] , [2] . Although the origin of Merkel cell has been debated, MCC is considered a Neuroendocrine tumor (NET) due to its characteristic histopathologic appearance expressing CD56, neurofilament protein (NFP), Chromogranin A, etc [2] , [3] . However there is growing evidence in the literature of metastatic histologically-proven MCC with unidentified primary site.…”

Section: Introductionmentioning

confidence: 99%

Merkel cell carcinoma of unknown primary site; case presentation and review of the literature

Kontis

Vezakis

Pantiora

et al. 2015

Annals of Medicine &Amp; Surgery

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Merkel cell carcinoma (MCC) is a rare skin malignancy associated with sun exposure and considered as a Neuroendocrine Tumor due to its characteristic histologic features. However there is increasing number of reports of Unknown Primary MCC's (UPMCC). Although initially UPMCC was considered a variant of known primary MCC, there is growing evidence that it could represent a different clinical entity.We present the case of a 60 year-old male patient who was referred to our department for surgical management of lymph node disease for UPMCC. The patient had undergone excisional biopsy of an inguinal lump, which was found to be an infiltrated lymph node by MCC. The patient underwent full imaging staging including a PET/CT, which failed to identify a primary site, and revealed only intra-abdominal lymph node disease. The patient underwent extended retroperitoneal and inguinal lymph node dissection and remains free of recurrence 16 months postoperatively.

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Section: Introductionmentioning

confidence: 99%

Merkel cell carcinoma of unknown primary site; case presentation and review of the literature

Kontis

Vezakis

Pantiora

et al. 2015

Annals of Medicine &Amp; Surgery

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“…A rapid growth of the lesion, suggesting its malignant character, constitutes a recommendation for excisional biopsy. Histopathological assessment with H&E staining has to be further confirmed with immunohistochemical staining: cytokeratin-20 (CK-20), thyroid transcription factor (TTF)-1, CD56, chromogranin A, synaptophysin, or neurofilament protein (NFE) [20,21]. CK-20 is a particularly sensitive marker of MCC.…”

Section: Diagnosticsmentioning

confidence: 99%

“…Gwałtowny wzrost zmiany sugerujący złośliwy charakter guza jest wskazaniem do wykonania biopsji wycinającej. Ocena histopatologiczna z zastosowaniem barwienia hematoksyliną i eozyną wymaga dalszego potwierdzenia barwieniami immunohistochemicznymi, takimi jak cytokeratyna 20 (CK-20), czynnik transkrypcyjny tarczycy (TTF) 1, CD56, chromogranina A, synaptofizyna i białko neurofilamentowe (NFE) [20,21]. CK-20 jest szczególnie czułym markerem MCC.…”

Section: Diagnostykaunclassified

Squamous cell carcinoma and Merkel-cell carcinoma. Diagnostic and therapeutic recommendations of the Polish Dermatological Society

Lesiak¹,

Czuwara²,

Kamińska‐Winciorek³

et al. 2019

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“…Curative surgery is commonly recommended to manage localized MCC. Nevertheless, specific postoperative palliative treatments for MCC have emerged, including radiotherapy (RT) or chemotherapy, due to the high local failure rate and the aggressive nature of the disease [4].…”

Section: Introductionmentioning

confidence: 99%

Management of an Unknown Primary Merkel Cell Carcinoma: A Case Report

et al. 2018

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Merkel cell carcinoma (MCC) represents a rare skin cancer associated with sun exposure. It is an uncommon skin neoplasm of the elderly population. The majority of patients with MCC present with localized disease at diagnosis and few patients have regional lymph node (LN) involvement and distant metastases. Although it has been previously reported in various anatomical sites, LN metastatic MCC in the absence of a primary site is extremely rare and for this reason there is no standard approach to its management. Currently, there is no standard approach to the management of MCC in the absence of a primary site. Since the disease is highly aggressive and the failure rate following surgery alone is high, radiotherapy (RT) is usually administered as temporary support for numerous patients with MCC.

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Neuroendocrine Merkel cell nodal carcinoma of unknown primary site: Management and outcomes of a rare entity

Cited by 25 publications

References 35 publications

Merkel cell carcinoma of unknown primary site; case presentation and review of the literature

Merkel cell carcinoma of unknown primary site; case presentation and review of the literature

Squamous cell carcinoma and Merkel-cell carcinoma. Diagnostic and therapeutic recommendations of the Polish Dermatological Society

Management of an Unknown Primary Merkel Cell Carcinoma: A Case Report

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