Mercury in muscle and brain of catfish from the Madeira river, Amazon, Brazil

Bastos, Wanderley Rodrigues; Dórea, José G.; Bernardi, José Vicente Elias; Lauthartte, Leidiane Caroline; Mussy, Marília Higino; Hauser, Marília; Doria, Carolina Rodrigues da Costa; Malm, Olaf

doi:10.1016/j.ecoenv.2015.04.015

Cited by 20 publications

(15 citation statements)

References 54 publications

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“…Pilsner et al (2010) examined global DNA methylation and THg in the brains of polar bears ( Ursus maritimus ), and found no correlation between the two. In addition, mean THg concentrations in bear brains were lower those observed in the studies of other wildlife (Bastos et al, 2015; Fortin et al, 2001; Heaton-Jones et al, 1997). However, the size class of bears sampled was heavily skewed toward sub-adults.…”

Section: Resultsmentioning

confidence: 60%

Global DNA methylation loss associated with mercury contamination and aging in the American alligator (Alligator mississippiensis)

Nilsen

Parrott

Bowden

et al. 2016

Science of The Total Environment

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Mercury is a widespread environmental contaminant with exposures eliciting a well-documented catalog of adverse effects. Yet, knowledge regarding the underlying mechanisms by which mercury exposures are translated into biological effects remains incomplete. DNA methylation is an epigenetic modification that is sensitive to environmental cues, and alterations in DNA methylation at the global level are associated with a variety of diseases. Using a liquid chromatography tandem mass spectrometry-based (LC-MS/MS) approach, global DNA methylation levels were measured in red blood cells of 144 wild American alligators (Alligator mississippiensis) from 6 sites with variable levels of mercury contamination across Florida’s north-south axis. Variation in mercury concentrations measured in whole blood was highly associated with location, allowing the comparison of global DNA methylation levels across different “treatments” of mercury. Global DNA methylation in alligators across all locations was weakly associated with increased mercury exposure. However, a much more robust relationship was observed in those animals sampled from locations more highly contaminated with mercury. Also, similar to other vertebrates, global DNA methylation appears to decline with age in alligators. The relationship between age-associated loss of global DNA methylation and varying mercury exposures was examined to reveal a potential interaction. These findings demonstrate that global DNA methylation levels are associated with mercury exposure, and give insights into interactions between contaminants, aging, and epigenetics.

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Section: Resultsmentioning

confidence: 60%

Global DNA methylation loss associated with mercury contamination and aging in the American alligator (Alligator mississippiensis)

Nilsen

Parrott

Bowden

et al. 2016

Science of The Total Environment

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“…However, over the past 5 years, with the implementation of hydroelectric plants in the Amazon Rivers, mercurial species hitherto inert in the sediments have been made available to the water column [4][5][6][7]. The damming of the river, necessary for the construction of hydroelectric power plants, can promote the transformation of available mercury in inorganic form into organic forms such as methylmercury, which is a highly toxic species that bioaccumulates in living organisms [3,6,8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Mercury can accumulate in tissues and organs of aquatic organisms at concentrations higher than those found in water [10,11]. In humans, it is able to pass through biological membranes of the mother to the fetus, causing anatomical abnormalities and severe damage to the central nervous system [2,8,12,13]. High concentrations of mercury in rodents and humans can cause hepatotoxicity, nephrotoxicity, and neurological damage [8,14].…”

Section: Introductionmentioning

confidence: 99%

Mercury Exposure: Protein Biomarkers of Mercury Exposure in Jaraqui Fish from the Amazon Region

Vieira

Braga

Oliveira

et al. 2017

Biol Trace Elem Res

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This study presents data on the extraction and characterization of proteins associated with mercury in the muscle and liver tissues of jaraqui (Semaprochilodus spp.) from the Madeira River in the Brazilian Amazon. Protein fractionation was carried out by two-dimensional electrophoresis (2D-PAGE). Mercury determination in tissues, pellets, and protein spots was performed by graphite furnace atomic absorption spectrometry (GFAAS). Proteins in the spots that showed mercury were characterized by electrospray ionization tandem mass spectrometry (ESI-MS/MS). The highest mercury concentrations were found in liver tissues and pellets (426 ± 6 and 277 ± 4 μg kg), followed by muscle tissues and pellets (132 ± 4 and 86 ± 1 μg kg, respectively). Mercury quantification in the protein spots allowed us to propose stoichiometric ratios in the range of 1-4 mercury atoms per molecule of protein in the protein spots. The proteins characterized in the analysis by ESI-MS/MS were keratin, type II cytoskeletal 8, parvalbumin beta, parvalbumin-2, ubiquitin-40S ribosomal S27a, 39S ribosomal protein L36 mitochondrial, hemoglobin subunit beta, and hemoglobin subunit beta-A/B. The results suggest that proteins such as ubiquitin-40S ribosomal protein S27a, which have specific domains, possibly zinc finger, can be used as biomarkers of mercury, whereas mercury and zinc present characteristics of soft acids.

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“…In aquatic conditions, the natural mercury is biologically transformed into organic mercury by different types of microorganisms, basically anaerobic bacteria [7]. Mercury concentrations in fish vary with tissue type, species, age, sex, biometrics (weight and length), temperature and trophic level, as well as the location of fish [8][9][10]. The typical concentration of Hg in edible tissues of various species of fish ranges from 50 to 1400 mg/kg of fresh weight; however, fish from contaminated aquatic environments can have 10 mg/kg [11].…”

Section: Introductionmentioning

confidence: 99%

“…In light of this view, organic mercury bearing microorganisms ingested by the higher animals, or the microorganisms freeing the organic mercury to the aquatic environment may be rapidly absorbed by the plankton that may also be ingested by the next level of organism in the food-web [19,20]. The central nervous system is a critical target for Hg toxicity in all living organisms [8]. Inorganic and organic mercury are both responsible for damaging the brain of bony fish [20].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Dietary Organic and Inorganic Mercury Threshold Levels on Induced Mercury Toxicity in a Marine Fish Model

Raihan

Moniruzzaman

Park

et al. 2020

Animals

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Mercury as one of the most toxic elements can be present in organic or inorganic form in marine fishes, which may cause a potential threat to public health. In this study, we investigated to determine the dietary organic (O-Hg) and inorganic (I-Hg) mercury threshold levels on induced mercury toxicity in juvenile olive flounder, Paralichthys olivaceus as a marine fish model. Twenty-eight fish averaging 3.1 ± 0.05 g (mean ± SD) were arbitrarily assigned to each of 27 tanks. Each tank was arbitrarily restricted to triplicates of nine experimental diets for eight weeks. The experimental diets were manufactured to contain 0 (Control), 10 (I-Hg10, O-Hg10), 20 (I-Hg20, O-Hg20), 40 (I-Hg40, O-Hg40) and 160 (I-Hg160, O-Hg160) mg/kg diet in organic form as methylmercury (MeHg) or in inorganic form as mercuric chloride (HgCl2). At the termination of the experimental trial, weight gains (WGs) of fish fed the control and 10 (I-Hg10, O-Hg10) diets were remarkably higher than those of fish fed the 20 (I-Hg20, O-Hg20), 40 (I-Hg40, O-Hg40) and 160 (I-Hg160, O-Hg160) (p < 0.05). Specific growth rate and feed efficiency of fish fed control and 10 (I-Hg10, O-Hg10) diets were significantly higher than those of fish fed 40 (I-Hg40, O-Hg40) and 160 (I-Hg160, O-Hg160) diets. In comparison to the dietary inorganic mercury, dietary MeHg bioaccumulation rates were significantly higher in the tissue levels according to the dietary inclusion levels. MeHg accumulated mostly in kidney, followed by liver and gill tissues. HgCl2 accumulated in tissues, in decreasing order, liver > kidney > gills. A broken-line regression model for percentage of WG indicated that the threshold toxicity level for an Hg-incorporated diet of juvenile olive flounder could be 13.5 mg Hg/kg in the form of HgCl2 and 8.7 mg Hg/kg in the form of MeHg.

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Mercury in muscle and brain of catfish from the Madeira river, Amazon, Brazil

Cited by 20 publications

References 54 publications

Global DNA methylation loss associated with mercury contamination and aging in the American alligator (Alligator mississippiensis)

Global DNA methylation loss associated with mercury contamination and aging in the American alligator (Alligator mississippiensis)

Mercury Exposure: Protein Biomarkers of Mercury Exposure in Jaraqui Fish from the Amazon Region

Evaluation of Dietary Organic and Inorganic Mercury Threshold Levels on Induced Mercury Toxicity in a Marine Fish Model

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