Mercurio y salud en la odontología

Fuentes, Ivelin Morales; Gil, Rosa Reyes

doi:10.1590/s0034-89102003000200018

Cited by 8 publications

(2 citation statements)

References 28 publications

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“…Electrochemistry is an advantageous analytical tool that is adaptable to an in-the-field device, in light of its portability, and can exhibit sensitivity and selectivity toward many target analytes. − There is only one study in the literature reporting the electrochemical reduction of 4-MMC using a dropping mercury electrode (DME) by Krishnaiah et al, detailing an analytical range of 2.7 × 10 –4 to 1.8 μg mL –1 with a detection limit of 2.2 × 10 –3 μg mL –1 . While yielding favorable analytical responses, a problem does arise with the use of a DME since mercury is widely reported as a harmful chemical and banned in numerous countries. − Additionally, there is a need to translate a method like this into that of one which could be used as an in-the-field sensor and potentially be applied to seized samples; consequently, this prior work is unlikely to be adopted as either a laboratory tool or in-the-field sensor and is yet to be properly applied and validated in seized street samples.…”

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confidence: 99%

Forensic Electrochemistry Applied to the Sensing of New Psychoactive Substances: Electroanalytical Sensing of Synthetic Cathinones and Analytical Validation in the Quantification of Seized Street Samples

et al. 2014

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The electrochemical sensing of new psychoactive substance(s) (NPSs), synthetic cathinone derivatives also termed "legal highs", are explored with the use of metallic modified screen-printed electrochemical sensors (SPES). It is found that no significant electrochemical enhancement is evident with the use of either in situ bismuth or mercury film modified SPES compared to the bare underlying electrode substrate. In fact, the direct electrochemical reduction of the cathinone derivatives mephedrone (4-methylmethcathinone; 4-MMC) and 4'-methyl-N-ethylcathinone (4-methylethcathinone; 4-MEC) is found to be possible for the first time, without heavy metal catalysis, giving rise to useful voltammetric electroanalytical signatures in model aqueous buffer solutions. This novel electroanalytical methodology is validated toward the determination of cathinone derivatives (4-MMC and 4-MEC) in three seized street samples that are independently analyzed with high-performance liquid chromatography (HPLC) wherein excellent agreement between the two analytical protocols is found. Such an approach provides a validated laboratory tool for the quantification of synthetic cathinone derivatives and holds potential for the basis of a portable analytical sensor for the determination of synthetic cathinone derivatives in seized street samples.

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confidence: 99%

Forensic Electrochemistry Applied to the Sensing of New Psychoactive Substances: Electroanalytical Sensing of Synthetic Cathinones and Analytical Validation in the Quantification of Seized Street Samples

et al. 2014

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“…En esta oportunidad se exhibe la aplicación del enfoque por procesos al trabajo de campo de la investigación "Gestión ambiental de la amalgama dental en el departamento de Antioquia", realizada por el grupo Ciencia y Tecnología Biomédica (CTB) de la Facultad de Ingeniería de la Universidad de Antioquia (Colombia) y por la empresa New Stetic S.A. Dicha investigación surge a raíz de la problemática ambiental y de salud que representa el uso inadecuado del mercurio en la profesión odontológica [1,2].…”

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Uso Del Enfoque Por Procesos en La Actividad Investigativa

Rave

Córdoba

Mesa

2007

Ingeniare. Rev. chil. ing.

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La realización de una investigación no sólo comprende actividades propias del campo de conocimiento de donde proviene la idea, sino también labores de gestión que permitan llevar a cabo de manera efectiva todas las etapas investigativas. Estas labores, en la mayoría de los casos subvaloradas en el campo investigativo, pero bien apreciadas en el contexto empresarial, son determinantes en el éxito de un proyecto de investigación. El enfoque por procesos constituye una de las principales bases de las prácticas de gestión que caracterizan a exitosas organizaciones empresariales y, en esta oportunidad, se exhibe la experiencia de aplicarlo al trabajo de campo de la investigación realizada por un grupo de la Universidad de Antioquia (Colombia). Este artículo pretende motivar y potenciar el desarrollo y/o la adaptación de modelos y técnicas de gestión en el ámbito investigativo, que propicien un desarrollo más eficaz y eficiente de las labores de investigación. En esta experiencia se define la misión del trabajo de campo, se identifican los procesos clave, se describe y se documenta cada uno de ellos y se realiza sensibilización y capacitación del equipo investigador en tales temas. Palabras clave: Enfoque por procesos, trabajo de campo, gestión de la investigación, procesos clave.

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Forensic electrochemistry: the electroanalytical sensing of synthetic cathinone-derivatives and their accompanying adulterants in “legal high” products

Smith

Metters

Irving

et al. 2014

Analyst

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The production and abuse of new psychoactive substances, known as "legal highs" which mimic traditional drugs of abuse is becoming a global epidemic. Traditional analytical methodologies exist which can provide confirmatory analysis but there is a requirement for an on-the-spot analytical screening tool that could be used to determine whether a substance, or sample matrix contains such legal, or formally "legal highs". In this paper the electrochemical sensing of (±)-methcathinone and related compounds at a range of commercially available electrode substrates is explored. We demonstrate for the first time that this class of "legal highs" are electrochemically active providing a novel sensing protocol based upon their electrochemical oxidation. Screen-printed graphite sensing platforms are favoured due to their proven ability to be mass-produced providing large numbers of reliable and reproducible electrode sensing platforms that preclude the requirement of surface pre-treatment such as mechanical polishing as is the case in the use of solid/re-usable electrode substrates. Additionally they hold potential to be used on-site potentially being the basis of an on-site legal high screening device. Consequently the electroanalytical sensing of (±)-methcathinone (3a), (±)-4′-methylmethcathinone [3b, 4-MMC, (±)-mephedrone] and (±)-4′-methyl-N-ethylcathinone (3c, 4-MEC) is explored using screen-printed sensing platforms with the effect of pH explored upon the analytical response with their analytical efficiency evaluated towards the target legal highs. Interesting at pH values below 6 the voltammetric response quantitatively changes from that of an electrochemically irreversible response to that of a quasi-reversible signature which can be used analytically. It is demonstrated for the first time that the electroanalytical sensing of (±)-methcathinone (3a), (±)-mephedrone (3b) and 4-MEC (3c) are possible with accessible linear ranges found to correspond to 16–200 μg mL(−1) for 3a (at pH 12) and 16–350 μg mL(−1) for both 3b and 3c in pH 2, with limits of detection (3σ) found to correspond to 44.5, 39.8 and 84.2 μg mL(−1) respectively. Additionally adulterants that are commonly incorporated into cathinone legal highs are electrochemically explored at both pH 2 and 12.

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Mercurio y salud en la odontología

Cited by 8 publications

References 28 publications

Forensic Electrochemistry Applied to the Sensing of New Psychoactive Substances: Electroanalytical Sensing of Synthetic Cathinones and Analytical Validation in the Quantification of Seized Street Samples

Forensic Electrochemistry Applied to the Sensing of New Psychoactive Substances: Electroanalytical Sensing of Synthetic Cathinones and Analytical Validation in the Quantification of Seized Street Samples

Uso Del Enfoque Por Procesos en La Actividad Investigativa

Forensic electrochemistry: the electroanalytical sensing of synthetic cathinone-derivatives and their accompanying adulterants in “legal high” products

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