2014
DOI: 10.1021/ac502991g
|View full text |Cite
|
Sign up to set email alerts
|

Forensic Electrochemistry Applied to the Sensing of New Psychoactive Substances: Electroanalytical Sensing of Synthetic Cathinones and Analytical Validation in the Quantification of Seized Street Samples

Abstract: The electrochemical sensing of new psychoactive substance(s) (NPSs), synthetic cathinone derivatives also termed "legal highs", are explored with the use of metallic modified screen-printed electrochemical sensors (SPES). It is found that no significant electrochemical enhancement is evident with the use of either in situ bismuth or mercury film modified SPES compared to the bare underlying electrode substrate. In fact, the direct electrochemical reduction of the cathinone derivatives mephedrone (4-methylmethc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

3
78
0
3

Year Published

2015
2015
2021
2021

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 81 publications
(84 citation statements)
references
References 47 publications
3
78
0
3
Order By: Relevance
“…47 The authors scope for this work is to provide a rapid screening method to quickly respond to the rapid evolution of designer drugs and the consequent testing backlogs that develop. 50 This work demonstrated for the first time a rapid, accurate, and sensitive method for the quantification of synthetic cathinone components found in seized street "legal high" samples (NRG-2) via the use of an electrochemical protocol utilizing graphite screen-printed electrodes (GSPEs) which was also independently verified with HPLC. 48,49 Smith et al 50,51 provided an alternative to chromatography and proposed a novel sensing protocol based upon the electrochemical methods.…”
Section: Usual Namesmentioning
confidence: 91%
See 3 more Smart Citations
“…47 The authors scope for this work is to provide a rapid screening method to quickly respond to the rapid evolution of designer drugs and the consequent testing backlogs that develop. 50 This work demonstrated for the first time a rapid, accurate, and sensitive method for the quantification of synthetic cathinone components found in seized street "legal high" samples (NRG-2) via the use of an electrochemical protocol utilizing graphite screen-printed electrodes (GSPEs) which was also independently verified with HPLC. 48,49 Smith et al 50,51 provided an alternative to chromatography and proposed a novel sensing protocol based upon the electrochemical methods.…”
Section: Usual Namesmentioning
confidence: 91%
“…Further advancements in this methodology by the same authors 47 has seen the application of a time-of-flight (TOF) mass analyzer along with in-source collision-induced dissociation (CID) spectra to provide data for presumptive analysis of various synthetic cathinones in a similar fashion to GC-MS analysis. 50 Analysed in pH 4.3 acetate buffer, limits of detection were found to correspond to 11.80 μg mL −1 for 4-MMC and 11.60 μg mL −1 for 4-MEC. 46,47 Ion mobility spectrometry (IMS) has also been applied to the screening of an array of NPSs within the literature with acceptable results.…”
Section: Usual Namesmentioning
confidence: 95%
See 2 more Smart Citations
“…To this end, the use of a dropping mercury electrode was shown to detect mephedrone in urine, 32 and more recently Smith et al demonstrated the use of screen-printed electrochemical sensors for the detection of cathinone derivatives. 33,34 On the other hand, portable instruments are also available for several solid-state spectroscopic techniques such as ATR-FT-IR, near-infrared (NIR) and Raman. NIR and Raman spectroscopy are rapid and non-destructive, where several different samples can be measured within minutes.…”
Section: Introductionmentioning
confidence: 99%