Mequinol-loaded carboxymethyl cellulose/chitosan electrospun wound dressing as a potential candidate to treat diabetic wounds

Abdelbasset, Walid Kamal; Elkholi, Safaa M.; Ismail, Khadiga Ahmed; Al-Ghamdi, Hasan S.; Mironov, S N; Ridha, Hussein S. H.; Maashi, Marwah Suliman; Thangavelu, Lakshmi; Mahmudiono, Trias; Mustafa, Yasser Fakri

doi:10.1007/s10570-022-04753-w

Cited by 18 publications

(8 citation statements)

References 49 publications

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“…CLV and RP, known to have antioxidant effects, still have antioxidant properties even though the polymer solution was exposed to a high electrical potential during the electrospinning process. Similar results were also reported from the literature that the antioxidant activity of bioactive compounds was preserved after loading in the CA matrix and fabricating by electrospinning. ,,, According to the results of the DPPH test, the release of CLV and RP from the CA/RP/5CLV nanofiber may quench hydrogen peroxide-induced free radicals and protect the cells against oxidative stress, and this nanofiber has the potential to accelerate the in vivo wound healing process. , …”

Section: Resultssupporting

confidence: 84%

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Enrichment of Cellulose Acetate Nanofibrous Scaffolds with Retinyl Palmitate and Clove Essential Oil for Wound Healing Applications

Aktürk

2023

ACS Omega

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The use of biocompatible materials and fabrication methods is of particular importance in the development of wound dressings. Cellulose acetate (CA) has excellent properties for wound dressing applications, but it is insufficient for the wound healing process due to its lack of bioactive and antibacterial properties. In this study, CA was electrospun with retinyl palmitate (RP) and clove essential oil (CLV) to fabricate a novel antibacterial and antioxidant biomaterial. The effects of RP and CLV incorporation on the surface morphology, fiber diameter, antioxidant activity, antibacterial activity, cell viability, and release behavior of the fabricated CA mats were investigated. In light of these studies, it was determined that the nanofiber mat, fabricated with a 15% w/v CA polymer concentration, a 1% w/w RP ratio, and a 5% w/w CLV ratio, was biocompatible with L929 fibroblast cells with antibacterial and antioxidant properties. Overall, results showed that this nanofiber offers promise for use as a wound dressing.

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Section: Resultssupporting

confidence: 84%

“… 8 , 23 , 41 , 50 According to the results of the DPPH test, the release of CLV and RP from the CA/RP/5CLV nanofiber may quench hydrogen peroxide-induced free radicals and protect the cells against oxidative stress, and this nanofiber has the potential to accelerate the in vivo wound healing process. 45 , 51 …”

Section: Resultsmentioning

confidence: 99%

Enrichment of Cellulose Acetate Nanofibrous Scaffolds with Retinyl Palmitate and Clove Essential Oil for Wound Healing Applications

Aktürk

2023

ACS Omega

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“…In vivo experiments performed on diabetic mice demonstrated their ability to improve the healing rate and skin quality and better results were obtained at higher CH concentration, able to ensure a complete wound recovery after 14 days. CH was also successfully mixed with carboxymethyl cellulose (CMC) at different concentrations (0.3–0.9% w / w ) to synthesize a tridimensional hydrophilic scaffold proposed as a mequinol carrier in the treatment of diabetic wounds [ 109 ]. Mequinol is an active phenolic molecule known as a potent antioxidant able to prevent lipid peroxidation and protect cells against oxidative stress in diabetic wounds [ 110 ].…”

Section: Polymeric Compoundsmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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Rapid and complete wound healing is a clinical emergency, mainly in pathological conditions such as Type 2 Diabetes mellitus. Many therapeutic tools are not resolutive, and the research for a more efficient remedial remains a challenge. Wound dressings play an essential role in diabetic wound healing. In particular, biocompatible hydrogels represent the most attractive wound dressings due to their ability to retain moisture as well as ability to act as a barrier against bacteria. In the last years, different functionalized hydrogels have been proposed as wound dressing materials, showing encouraging outcomes with great benefits in the healing of the diabetic wounds. Specifically, because of their excellent biocompatibility and biodegradability, natural bioactive compounds, as well as biomacromolecules such as polysaccharides and protein, are usually employed in the biomedical field. In this review, readers can find the main discoveries regarding the employment of naturally occurring compounds and biopolymers as wound healing promoters with antibacterial activity. The emerging approaches and engineered devices for effective wound care in diabetic patients are reported and deeply investigated.

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“…Zhao et al used CMC and CS to prepare solid polyelectrolyte complexes and then dissolved the complexes in aqueous sodium hydroxide to prepare complex membranes by solution casting and evaporation . Besides, freeze-drying and electrostatic spinning are also used to prepare membranes based on CMC and CS. , However, these methods either need support materials or significant time and/or energy consumption. Therefore, it is promising to use the APS technique to fabricate free-standing membranes via the one-step way without the use of organic solvents.…”

Section: Introductionmentioning

confidence: 99%

“…33 Besides, freeze-drying and electrostatic spinning are also used to prepare membranes based on CMC and CS. 34,35 However, these methods either need support materials or significant time and/or energy consumption. Therefore, it is promising to use the APS technique to fabricate free-standing membranes via the one-step way without the use of organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Sodium Carboxymethyl Cellulose–Chitosan Complex Membranes through Sustainable Aqueous Phase Separation

Baig

Vos

et al. 2023

ACS Appl. Polym. Mater.

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The aqueous phase separation (APS) technique has recently been introduced as one of the more sustainable methods to produce polymeric membranes. So far, almost all the APS membranes are produced on the basis of synthetic polyelectrolytes that are typically obtained from petroleum sources. In this work, we utilized natural polyelectrolytes to produce even more sustainable membranes via APS. Two natural polyelectrolytes, polyanionic sodium carboxymethyl cellulose (CMC) and polycationic chitosan (CS), were used to fabricate the polyelectrolyte complex membranes. By changing the solution pH and monomer ratio of polyelectrolytes, a desired homogeneous casting solution was prepared at pH ∼1 where CMC was uncharged. Exposing this solution to an acetate buffer coagulation bath at pH ∼5 caused CMC to acquire negative charges, leading to the formation of a polyelectrolyte complex with the positively charged CS. The structure and properties of the resultant membranes could be tuned by changing the concentration and pH of the acetate buffer. All the membranes showed an asymmetric structure with a dense top layer and porous inner structure. The membranes possessed tunable pure water permeability and were able to effectively (∼99%) remove oil droplets from an oil-in-water emulsion. This work demonstrates that natural polyelectrolytes can indeed be used to produce more sustainable APS membranes that can be directly applied for water treatment.

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Mequinol-loaded carboxymethyl cellulose/chitosan electrospun wound dressing as a potential candidate to treat diabetic wounds

Cited by 18 publications

References 49 publications

Enrichment of Cellulose Acetate Nanofibrous Scaffolds with Retinyl Palmitate and Clove Essential Oil for Wound Healing Applications

Enrichment of Cellulose Acetate Nanofibrous Scaffolds with Retinyl Palmitate and Clove Essential Oil for Wound Healing Applications

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

Preparation of Sodium Carboxymethyl Cellulose–Chitosan Complex Membranes through Sustainable Aqueous Phase Separation

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