The current research focuses on the findings of an investigation on optimizing of an electrospun antibacterial gelatin nanocomposite membrane for bone tissue engineering applications. For this reason, soluble starch coated silver nanoparticles (Ag‐NPs) and bioactive glass particles (BG) were incorporated in to gelatin (Gt) to fabricate Gt/Ag‐NPs/BG nanocomposite membranes. Employing Box‐Behnken design, second‐order models have been successfully obtained to evaluate the statistical significance of individual and interaction effects of applied voltage, tip‐to‐collector distance (TCD), and flow rate on fiber diameter. There was a reasonable agreement between the regression R2 value (0.9542), R2 predicted value (0.8768), and the R2 adjusted value (0.9286) across the entire factor space with identical observations for the experimental and model values. Under optimum conditions (applied voltage of 26 kV, TCD of 180 mm, and flow rate of 0.5 mL/h), the nanocomposite membrane with similar fiber size of bone tissue extracellular matrix can be fabricated with the predicted value of 557 nm obtained by the proposed model. The optimized nanofiber membrane was fabricated under these conditions and average fiber diameter of this membrane was found as 472 ± 94 nm. The characterization studies of this nanofiber suggest that obtained nanocomposite is a potential candidate for bone tissue engineering applications.
The use of biocompatible materials and fabrication methods
is of
particular importance in the development of wound dressings. Cellulose
acetate (CA) has excellent properties for wound dressing applications,
but it is insufficient for the wound healing process due to its lack
of bioactive and antibacterial properties. In this study, CA was electrospun
with retinyl palmitate (RP) and clove essential oil (CLV) to fabricate
a novel antibacterial and antioxidant biomaterial. The effects of
RP and CLV incorporation on the surface morphology, fiber diameter,
antioxidant activity, antibacterial activity, cell viability, and
release behavior of the fabricated CA mats were investigated. In light
of these studies, it was determined that the nanofiber mat, fabricated
with a 15% w/v CA polymer concentration, a 1% w/w RP ratio, and a
5% w/w CLV ratio, was biocompatible with L929 fibroblast cells with
antibacterial and antioxidant properties. Overall, results showed
that this nanofiber offers promise for use as a wound dressing.
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