Mental health burden amongst inhabitants of an arsenic-affected area in Inner Mongolia, China

Fujino, Yoshihisa; Guo, Xin-Heng; Jun, Liu; You, Lingui; Miyatake, Munetoshi; Yoshimura, Takesumi

doi:10.1016/j.socscimed.2004.02.031

Cited by 43 publications

(19 citation statements)

References 11 publications

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“…)↓capacity in visual searchRosado et al 2007 [14]Low and HighChildren (5-15 y.o. )↓capacity in picture completion, object assemblyVon Ehrenstein et al 2007 [16]Mental healthMediumChildren↑risk for ADHDRoy et al 2011 [15]LowAdults↑incidence of depressionZierold et al 2004 [53]MediumAdults↑symptoms of anxietyDang et al 2008 [50], Dang et al 2009Low → HighAdults↓quality of life and mental healthSyed et al 2012 [47]HighAdults↑symptoms of altered mental healthFujino et al 2004 [51]Low → HighAdults↑insomnia ↓general healthGuo et al 2007 [49]Low → HighAdults↑risk of psychiatric disorder, depression, anxietySen et al 2012 [52]ExposureLow: less than 50 μg/L (ppb) urinary arsenic or water arsenicMedium: between 50 μg/L (ppb) and 100 μg/L (ppb) urinary or water arsenicHigh: more than 100 μg/L (ppb) urinary arsenic or water arsenic…”

Section: Epidemiological Studiesmentioning

confidence: 99%

“…Arsenic toxicity studies from China typically focus on symptoms of neurotoxicity, including loss of hearing, loss of taste, blurred vision, and tingling/numbness in the limbs [49]. Altered mental health is comorbid with these ailments, including a prevalence of insomnia [49], anxiety and depression [50], and symptoms of distress [51]. Assessments of mental health were congruent with education levels of the participants; however, as described above, exposure to metal mixtures is common, and participants exposed to metals in one study showed significantly greater urine and hair concentrations of arsenic, lead, and cadmium than control participants [50].…”

Section: Epidemiological Studiesmentioning

confidence: 99%

See 1 more Smart Citation

The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review

Tyler

Allan

2014

Curr Envir Health Rpt

419

233

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Arsenic toxicity is a worldwide health concern as several millions of people are exposed to this toxicant via drinking water, and exposure affects almost every organ system in the body including the brain. Recent studies have shown that even low concentrations of arsenic impair neurological function, particularly in children. This review will focus on the current epidemiological evidence of arsenic neurotoxicity in children and adults, with emphasis on cognitive dysfunction, including learning and memory deficits and mood disorders. We provide a cohesive synthesis of the animal studies that have focused on neural mechanisms of dysfunction after arsenic exposure including altered epigenetics; hippocampal function; glucocorticoid and hypothalamus-pituitary-adrenal axis (HPA) pathway signaling; glutamatergic, cholinergic and monoaminergic signaling; adult neurogenesis; and increased Alzheimer’s-associated pathologies. Finally, we briefly discuss new studies focusing on therapeutic strategies to combat arsenic toxicity including the use of selenium and zinc.

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Section: Epidemiological Studiesmentioning

confidence: 99%

Section: Epidemiological Studiesmentioning

confidence: 99%

The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review

Tyler

Allan

2014

Curr Envir Health Rpt

419

233

View full text Add to dashboard Cite

show abstract

“…Recent studies attempt to predict other adverse health effects resulting from arsenic exposure. An investigation in Inner Mongolia indicated that the mental health of subjects in the arsenic-affected village was worse than those in the arsenic-free village (OR=2.5, 95%CI=1.1-6.0) [16]. Another investigation in Shanxi Province uncovered that exposure to arsenic in drinking water may affect children's intelligence and growth [17].…”

Section: Arsenismmentioning

confidence: 99%

Water Pollution and Health Impact in China: A Mini Review

Lu¹,

Xie²,

Zhou³

et al. 2008

TOENVIRSJ

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For the last 20-odd years in China, an economic boom has resulted in severe environmental pollution; water pollution, particularly, is of great concern. It has been reported that pollution in China's overall surface water is rated medium. The water quality of groundwater, lakes and reservoirs has deteriorated. Consequently, such a general distribution of water pollution has posed a grave threat to public health in China. The health impact of water pollution has been documented in the last several decades; these documents are reviewed in this paper on several outstanding aspects, including chronic mercurialism, arsenism, cancers related to microcystins, health problems caused by organic pollutants and water pollution accidents as well. Indubitably, water pollution and its health impact remain enormous challenges in China.

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“…This is exemplified by the fact that global warming is a major cause of the spread of a neurotropic agent, the West Nile virus [19,20]; its hosts and vectors are invading new areas favored by increase in rains and environmental temperatures. The neurotoxic effects on behavior and cognition of Chinese workers exposed to industrial pollution are also local and regional [21,22]. Polar pollution has not yet had human consequences but melting of the ice cap appears to have started with dire future consequences for coastal populations [19].…”

Section: Temporal and Spatial Dimensionsmentioning

confidence: 99%