Environmental neurology: A promising new field of practice and research

Reis, Jacques; Román, Gustavo C.

doi:10.1016/j.jns.2007.06.017

Cited by 14 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Exposure to and bioaccumulation of various chemical pollutants is increasingly being established as a widespread determinant in the development of neurodegenerative illness such as Alzheimer's Disease. Despite this recognition, chemical toxicant accrual as an etiological and potential reversible cause of illness has generally been overlooked in medicine, neurology, public health, and psychiatry [ 48 , 101 ]. While most people recognize that high-dose exposure to various chemical agents can alter brain function, there is not yet widespread recognition (other than with cigarettes) that ongoing exposure to low levels of toxic pollutants and chronic bioaccumulationcan of these agents can cause sustained disruption of physiologic function including brain biology.…”

Section: Discussionmentioning

confidence: 99%

“…However, there has been little appreciation within the medical community of neurodegenerative toxicants and their potential impact on the maturing adult segment of the population. As well as dementia, research continues to elucidate the relationship between environmental toxicant exposure and the development of other neurodegenerative diseases including Parkinson's Disease, Multiple Sclerosis, and Amyotrophic Lateral Sclerosis [ 7 , 28 , 30 , 46 – 48 ]. Table 1 provides an overview of some of the chemical toxicants that have been directly associated with neurodegenerative disease.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Toxicant Exposure and Bioaccumulation: A Common and Potentially Reversible Cause of Cognitive Dysfunction and Dementia

Genuis

Kelln

2015

Behavioural Neurology

View full text Add to dashboard Cite

Juxtaposed alongside the ongoing rise in the incidence and prevalence of dementia, is the surge of recent research confirming widespread exposure and bioaccumulation of chemical toxicants. Evidence from sources such as the Centers for Disease Control reveals that most people have accrued varying degrees of assorted toxic pollutants including heavy metals, flame retardants, and pesticide residues within their bodies. It has been well established that many of these toxicants have neurodegenerative as well as neurodevelopmental impact as a result of various pathophysiologic mechanisms including neuronal mitochondrial toxicity and disruption of neurotransmitter regulation. Elimination of stockpiled toxicants from the body may diminish adverse toxicant impact on human biology and allow restoration of normal physiological function. Incorporating a review of medical literature on toxicant exposure and dementia with a case history of a lead-exposed individual diagnosed with dementia, this paper will discuss a much overlooked and potentially widespread cause of declining brain function and dementia.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toxicant Exposure and Bioaccumulation: A Common and Potentially Reversible Cause of Cognitive Dysfunction and Dementia

Genuis

Kelln

2015

Behavioural Neurology

View full text Add to dashboard Cite

show abstract

“…Environmental risk factors are thus selected components of the exposome that are associated with adverse effects on the human organism and its health, wellbeing and longevity. Those risk factors interact in complex ways with the genome/epigenome to impact health and generate disease [1].…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

Medical management, prevention and mitigation of environmental risks factors in Neurology

et al. 2019

View full text Add to dashboard Cite

“…To this notion, we introduce the concept of environmental risk factors. A systematic approach should explore the multiple dimensions of these factors: their nature, sources, carriers, spatiotemporal characteristics, interactions (multicausality), and finally, health impacts (protective/harmless/noxious) (Reis and Roman, 2007).…”

Section: Introductionmentioning

confidence: 99%