Menopause, estrogens, progestins, or their combination on body weight and anthropometric measures

Cagnacci, Angelo; Zanin, Renata; Cannoletta, Marianna; Generali, Matteo; Caretto, Simona; Volpe, Annibale

doi:10.1016/j.fertnstert.2007.01.039

Cited by 31 publications

(12 citation statements)

References 41 publications

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“…These findings are consistent with the known anorexigenic effects of E 2 , as lack of this hormone in humans, for example during the menopausal transition, tends to increase body weight [52]. In addition, body weight data in EtOH treated groups showed that the repeated binge-pattern alcohol exposure paradigm employed in our experiments did not inhibit the normal overall growth of the animals.…”

Section: Discussionsupporting

confidence: 92%

17β-Estradiol Is Required for the Sexually Dimorphic Effects of Repeated Binge-Pattern Alcohol Exposure on the HPA Axis during Adolescence

Przybycien-Szymanska

Gillespie²,

Pak

2012

PLoS ONE

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Alcohol consumption during adolescence has long-term sexually dimorphic effects on anxiety behavior and mood disorders. We have previously shown that repeated binge-pattern alcohol exposure increased the expression of two critical central regulators of stress and anxiety, corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP), in adolescent male rats. By contrast, there was no effect of alcohol on these same genes in adolescent females. Therefore, we tested the hypothesis that 17β-estradiol (E2), the predominant sex steroid hormone in females, prevents alcohol-induced changes in CRH and AVP gene expression in the paraventricular nucleus (PVN) of the hypothalamus. To test this hypothesis, postnatal day (PND) 26 females were ovariectomized and given E2 replacement or cholesterol as a control. Next, they were given an alcohol exposure paradigm of 1) saline alone, 2) acute (single dose) or 3) a repeated binge-pattern. Our results showed that acute and repeated binge-pattern alcohol treatment increased plasma ACTH and CORT levels in both E2- and Ch-treated groups, however habituation to repeated binge-pattern alcohol exposure was evident only in E2-treated animals. Further, repeated binge-pattern alcohol exposure significantly decreased CRH and AVP mRNA in Ch-, but not E2-treated animals, which was consistent with our previous observations in gonad intact females. We further tested the effects of E2 and alcohol treatment on the activity of the wild type CRH promoter in a PVN-derived neuronal cell line. Alcohol increased CRH promoter activity in these cells and concomitant treatment with E2 completely abolished the effect. Together our data suggest that E2 regulates the reactivity of the HPA axis to a repeated stressor through modulation of the habituation response and further serves to maintain normal steady state mRNA levels of CRH and AVP in the PVN in response to a repeated alcohol stressor.

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Section: Discussionsupporting

confidence: 92%

17β-Estradiol Is Required for the Sexually Dimorphic Effects of Repeated Binge-Pattern Alcohol Exposure on the HPA Axis during Adolescence

Przybycien-Szymanska

Gillespie²,

Pak

2012

PLoS ONE

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“…57 Consultation with or referral to a mental health specialist should be assessed for each individual case. 102–104 However, anxiety, and bipolar and eating disorders, as well as complicated cases of depression, such as atypical, bipolar, or severe depression, are most appropriately managed by consultation with or referral to a specialist (Table 8). 105 Anxiety and depression symptoms are 2 of the most commonly clustered psychiatric symptom domains, and anxiety is often the chief presenting complaint for patients with depression and concomitant anxiety.…”

Section: Premenstrual Exacerbation Of Preexisting Mental Health Disormentioning

confidence: 99%

Menstrual cycle-related exacerbation of disease

Pinkerton¹,

Guico-Pabia²,

Taylor³

2010

American Journal of Obstetrics and Gynecology

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Exacerbation of common medical and mental health disorders at specific phases of the menstrual cycle is a prevalent phenomenon. Although the precise cause is unclear, studies implicate complex interactions between the immune and neuroendocrine systems. The menstrual cycle also is a trigger for the onset of depressive disorders, including premenstrual dysphoric disorder, a disorder specific to the luteal phase of the menstrual cycle, and depression associated with the transition to menopause. This article discusses common mental health problems exacerbated by the menstrual cycle, with a particular focus on premenstrual dysphoric disorder and perimenopausal depression. Throughout the reproductive lifespan, routine screening and assessment for the presence of common psychiatric disorders are critical for accurate diagnosis and provision of effective treatment. Management options include referral or consultation with a primary care provider or psychiatrist; treatment options for premenstrual dysphoric disorder and perimenopausal depression include pharmacotherapy with antidepressant agents and/or psychotherapy. Hormones may be helpful.

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“…Trouble sleeping, for example, is strongly associated with both the transition to menopause and with MDD. 24,26,43 In addition, weight gain may be experienced during perimenopause 44 and is also an atypical or reversed-vegetative symptom of MDD, 37 particularly prevalent among depressed women. 45 Rather than identifying a particular symptom, screening for the presence of MDD during perimenopause should focus on the overall number and type of depressive symptoms, duration of symptoms, and associated impairment.…”

Section: Risk Of Depression During Thementioning

confidence: 99%

Recognition of depression among women presenting with menopausal symptoms

Clayton

Guico-Pabia²

2008

Menopause

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Obstetricians and gynecologists are in a unique position to recognize depression in potentially at-risk patients. Proactive screening and diagnosis of depression are critical for successful treatment outcomes. Additional studies are needed to evaluate the effects of menopausal status on antidepressant response and to identify new, safe, and efficacious treatment options for depression during perimenopause.

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Menopause, estrogens, progestins, or their combination on body weight and anthropometric measures

Cited by 31 publications

References 41 publications

17β-Estradiol Is Required for the Sexually Dimorphic Effects of Repeated Binge-Pattern Alcohol Exposure on the HPA Axis during Adolescence

17β-Estradiol Is Required for the Sexually Dimorphic Effects of Repeated Binge-Pattern Alcohol Exposure on the HPA Axis during Adolescence

Menstrual cycle-related exacerbation of disease

Recognition of depression among women presenting with menopausal symptoms

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