Menstrual cycle-related exacerbation of disease

Pinkerton, JoAnn V.; Guico-Pabia, Christine J.; Taylor, Hugh S.

doi:10.1016/j.ajog.2009.07.061

Cited by 70 publications

(47 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is accumulating evidence but no definitive answers about many potential risk factors and the role of the changing hormone milieu associated with depressed mood around menopause. Further information is clinically important, because of the diminished functioning and significant disability that accompany depression [1,2], the exacerbation of disorders associated with the neuroendocrine system [3], and the associations of depression with other major health problems, including cardiovascular disease [4][5][6], metabolic syndrome [7][8][9] and osteoporosis [10,11], that complicate treatments and contribute substantially to disability and the high costs of health care.…”

Section: Introductionmentioning

confidence: 99%

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population

Freeman

2015

womens midlife health

View full text Add to dashboard Cite

There is accumulating evidence but no definitive answers about the incidence of depressed mood in the menopause transition and its association with the changing hormonal milieu. While a changing hormonal milieu is the natural condition for all women, only a minority of mid-life women experience debilitating depressive symptoms or clinical depression. This review focuses on associations between depressed mood and the menopause transition, primarily as identified in longitudinal, population-based studies in the past decade. Further aims were to present reported associations between depressed mood and reproductive hormones in the menopause transition as evaluated in the general population and associations of depressive symptoms or clinical depression with menopausal hot flashes or poor sleep in perimenopausal women. There is evidence to support the role of the changing endocrine milieu in the development of depressed mood in the menopause transition, but the contribution of hormones as measured is small. Disentangling the numerous factors that are associated with depression in midlife women is a major challenge for research and for clinical care, where treatments are needed to improve the most distressing menopausal symptoms.

show abstract

Section: Introductionmentioning

confidence: 99%

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population

Freeman

2015

womens midlife health

View full text Add to dashboard Cite

show abstract

“…These findings are especially relevant given the body of literature which indicates increased interpersonal sensitivity at the paramenstrual phase (Pinkerton et al 2010). Specifically, the increased persecution suggests that some women may interpret interpersonal interactions differently, making them more sensitive to perceived attacks or criticisms from others.…”

Section: Effect Of Cycle Phasementioning

confidence: 78%

“…Increased interpersonal over-sensitivity is commonly reported within the PMS literature and indeed could be considered one of the defining characteristics (Pinkerton et al 2010). This would strengthen the reasoning that both selfesteem and paranoia might fluctuate in response to menstrual cycle phase.…”

Section: Self-esteem and The Menstrual Cyclementioning

confidence: 96%

See 1 more Smart Citation

Relationships between paranoid thinking, self-esteem and the menstrual cycle

Brock

Rowse

Slade

2015

Arch Womens Ment Health

View full text Add to dashboard Cite

This study aimed to investigate whether paranoid experiences and levels of self-esteem fluctuate over the menstrual cycle and whether levels of self-esteem are lower when perceived persecution is felt to be deserved.Measures of anxiety, depression, persecution, deservedness and self-esteem were completed on-line by 278 women over their menstrual cycle. Responses were compared at the paramenstrual (three days before and after menses onset) and mid-cycle phase.At the paramenstrual phase persecution, negative self-esteem, anxiety and depression were higher and positive self-esteem was lower than at mid-cycle. A greater proportion of women experienced persecution as deserved at the paramenstrual phase. This was associated with higher depression and negative self-esteem scores.Increased levels of deservedness significantly strengthened the relationship between persecution and negative, but not positive, self-esteem.These findings suggest that the paramenstrual phase is a time of vulnerability to increased paranoid experiences, an increased likelihood that feelings of persecution will feel deserved and lowered self-esteem. The findings support the view that interpersonal sensitivities may be key to menstrual cycle symptoms and have an impact on relationships. Further, the study illustrated that ideas developed for psychosis could make a valuable contribution to understanding and managing this aspect of menstruation-related distress. KeywordsParanoia; Self-esteem; Menstruation; Premenstrual; Deservedness PARANOIA, SELF-ESTEEM AND THE MENSTRUAL CYCLE 3 Relationships between Paranoia, Self-Esteem and the Menstrual CycleThe menstrual cycle is characterised by hormonal fluctuations which accompany the processes of ovulation and menses in female human reproduction. The phases of the cycle have been linked to changes in both physical and psychological phenomena, the presentation and intensity of which varies considerably from woman to woman (Gonda et al. 2008). Typically, negative effects occur in the few days preceding and during menstruation. Increased interpersonal oversensitivity is commonly reported within the PMS literature (Pinkerton et al. 2010). Such sensitivities are likely to have major impacts upon relationships, and other commonly reported symptoms such as anxiety and depression. However, these sensitivities are rarely specifically investigated.! Paranoia and low self-esteem both reflect oversensitivity to interactions with others.Links between menstrual cycle phase and psychosis have long been postulated (see Brockington 2005 for a review). The literature also includes examples of exacerbation of bipolar disorder (Hendrick et al. 1996), exacerbation of schizophrenic symptoms (Harris 1997;Levitte 1997;Riecher-Rossler 2002;Hsiao et al. 2004;Bergemann et al. 2007) and the presentation of psychotic symptoms in major depression during the premenstrual and menstrual phases. Due to the physiological changes underpinning the menstrual cycle, research has focused upon physiological reasons for these phenomena, s...

show abstract

“…14 Further, we hypothesized that at second step treatment, an equal or greater proportion of women with reported PME would respond to a selective serotonin reuptake inhibitor (SSRI) as compared to women without reported PME, and a lesser proportion of women with reported PME would respond to bupropion-sustained release (bupropion-SR), given that SSRIs have been shown to be effective in treating premenstrual dysphoric disorder (PMDD) 15,16 and bupropion-SR has been shown to be ineffective for PMDD. 17 …”

mentioning

confidence: 99%

The Clinical Relevance of Self-Reported Premenstrual Worsening of Depressive Symptoms in the Management of Depressed Outpatients: A STAR*D Report

Haley

Sung

Rush

et al. 2013

Journal of Women's Health

View full text Add to dashboard Cite

Objective: To determine the incidence, clinical and demographic correlates, and relationship to treatment outcome of self-reported premenstrual exacerbation of depressive symptoms in premenopausal women with major depressive disorder who are receiving antidepressant medication. Method: This post-hoc analysis used clinical trial data from treatment-seeking, premenopausal, adult female outpatients with major depression who were not using hormonal contraceptives. For this report, citalopram was used as the first treatment step. We also used data from the second step in which one of three new medications were used (bupropion-SR [sustained release], venlafaxine-XR [extended release], or sertraline). Treatmentblinded assessors obtained baseline treatment outcomes data. We hypothesized that those with reported premenstrual depressive symptom exacerbation would have more general medical conditions, longer index depressive episodes, lower response or remission rates, and shorter times-to-relapse with citalopram, and that they would have a better outcome with sertraline than with bupropion-SR. Results: At baseline, 66% (n = 545/821) of women reported premenstrual exacerbation. They had more general medical conditions, more anxious features, longer index episodes, and shorter times-to-relapse (41.3 to 47

show abstract

Menstrual cycle-related exacerbation of disease

Cited by 70 publications

References 120 publications

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population

Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population

Relationships between paranoid thinking, self-esteem and the menstrual cycle

The Clinical Relevance of Self-Reported Premenstrual Worsening of Depressive Symptoms in the Management of Depressed Outpatients: A STAR*D Report

Contact Info

Product

Resources

About