Meningococcal A Vaccination Response is Enhanced by Acute Stress in Men

Edwards, Kate M.; Burns, Victoria E.; Adkins, Alison E.; Carroll, Douglas; Drayson, Mark T.; Ring, Christopher

doi:10.1097/psy.0b013e318164232e

Cited by 64 publications

(36 citation statements)

References 25 publications

(36 reference statements)

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“…Both stress tasks induced significant heart rate increases, and women exposed to the acute stressors had higher peak antibody responses to the A/Panama influenza strain than women in a no stress control condition (23). In addition, acute stress exposure prior to vaccination was also associated with an enhanced antibody response to meningococcal A in men (24). Finally, we have also found in this sample that responders to A/Panama showed a greater cortisol response to the acute stress task (25).…”

Section: Discussionsupporting

confidence: 56%

Cardiovascular activity and the antibody response to vaccination

Phillips

Burns

Drayson

2009

Journal of Psychosomatic Research

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Objective: To examine the relationship between cardiovascular activity in response to acute psychological stress and the antibody response to vaccination. \ud Methods: Fifty-seven healthy participants were vaccinated with the trivalent influenza vaccine and meningococcal A+C polysaccharides. Antibody levels were measured at baseline and 5-weeks post-vaccination. Cardiovascular activity was measured at rest, during and following a mental arithmetic stress task in 54 participants. \ud Results: Participants demonstrating a four-fold increase in antibody titre to the A/Panama and B/Shangdong influenza strains and to meningococcal A showed greater blood pressure reactions toward the end of the acute stress task. In addition, there was some evidence of delayed diastolic blood pressure recovery in those who were responders to A/Panama and B/Shangdong influenza strains. \ud Conclusion: The present results suggest that heightened cardiovascular reactivity to stress and delayed recovery may not necessarily be detrimental to all aspects of health, and may be associated with an enhanced immune response to antigen challenge. \u

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Section: Discussionsupporting

confidence: 56%

Cardiovascular activity and the antibody response to vaccination

Phillips

Burns

Drayson

2009

Journal of Psychosomatic Research

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“…Antibody responses were not uniformly enhanced, with women showing increased responses in both the exercise and stress groups to influenza vaccine compared with the control group, 18 contrasting with an increased response to meningococcal vaccine in men in exercise and stress groups. 19 Similar non-uniform responses in subsequent exercise on vaccination responses being elicited in older adult populations but not in younger populations is exemplified by Smith et al 8 who compared the immune response to a novel antigen (Keyhole limpet hemocyanin, KLH) in both young and older men. They showed that older active men demonstrated stronger antibody and cell-mediated responses to KLH than sedentary older men, while responses were similar regardless of activity habits in younger men.…”

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confidence: 85%

Effects of exercise on vaccine-induced immune responses

Edwards

Booy

2013

Human Vaccines & Immunotherapeutics

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“…Generally, chronic stress has been shown to have a negative effect on various aspects of immunity, whereas acute stress would seem to be immune enhancing (1). For example, acute stress has been shown to elicit lymphocytosis (2,3), increase natural killer cell cytotoxicity (4,5) and secretory immunoglobulin A secretion rate (6), stimulate aspects of the complement system (7), and boost vaccination responses (8). However, little is known about the effects of acute stress on human neutrophils and particularly their bactericidal function.…”

Section: Introductionmentioning

confidence: 99%

Altered Human Neutrophil Function in Response to Acute Psychological Stress

Khanfer

Phillips

Lord

2010

Psychosomatic Medicine

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Objective: To examine the effects of an acute laboratory psychological stress task on neutrophil function, specifically phagocytosis of Escherichia coli and stimulated superoxide production in human neutrophils. There is mounting evidence that acute stress is associated with short-term increases in a number of immune indices. Methods:Participants were 40 (n = 20 females) university students (mean age, 25.9 ± 4.56 years). Blood samples to determine neutrophil function by flow cytometry were taken at the end of resting baseline, during an acute stress task, and during recovery. The stress task was a 10-minute timepressured mental arithmetic challenge with social evaluation. Results:There was an acute increase in phagocytic ability, p = .047, ²p = 0.076, and a reduction of superoxide production, p = .026, ²p = 0.101, associated with the stress task relative to baseline. Conclusion:These findings suggest that neutrophil bactericidal function may be sensitive to mental challenge tasks that provoke acute psychological stress. Further research is needed to replicate the observed psychological stress-induced changes in neutrophil function.Key words: acute psychological stress, neutrophil, phagocytosis, superoxide production. SBP = systolic blood pressure; DBP = diastolic blood pressure; HR = heart rate; MFI = mean fluorescent intensity; EDTA = ethylene diamine tetraacetic acid.

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Meningococcal A Vaccination Response is Enhanced by Acute Stress in Men

Abstract: Stress-induced immune enhancement has now been demonstrated in the antibody response to thymus-independent as well as thymus-dependent vaccines. These findings indicate that this effect is not specific to T-cell involvement.

Cited by 64 publications

References 25 publications

Cardiovascular activity and the antibody response to vaccination

Cardiovascular activity and the antibody response to vaccination

Effects of exercise on vaccine-induced immune responses

Altered Human Neutrophil Function in Response to Acute Psychological Stress

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