“…Mortality ascribed to cryptococcosis in 35 AIDS patients at Emilio Ribas Infectious Disease Institute was 79% 65 . General mortality in cryptococcosis patients, with or without underlying disease, is around 45% -65%, according to Brazilian studies 12,28,31,35,60,61 . A study of 17 cases of CNS cryptococcosis showed that clinical aspects, follow-ups and necroscopy findings were influenced by the presence and the kind of immunodeficiency, that is, a worst prognosis being seen in patients with pre-existing primary disease, such as, diabetes or neoplasia, in comparison to immunodepressed cases under renal transplant therapy or immunocompetent patients 28 .…”