Men and women show similar survival outcome in stage IV breast cancer

Wu, San‐Gang; Zhang, Wen; Liao, Xu‐Lin; Sun, Jiayuan; Li, Fengyan; Su, Jingjun; He, Zhen-Yu

doi:10.1016/j.breast.2017.05.012

Cited by 7 publications

(8 citation statements)

References 33 publications

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“…Although metastatic MBC patients had unique clinicopathological features and metastatic pattern, we found that there was no difference in OS compared with metastatic FBC patients. Our results were consistent with those of other similar studies, such as stage IV breast cancer patients, 34 gastric cancer patients with liver metastasis, 41 and colorectal signet ring cell carcinoma patients with distant metastasis. 42 Multivariate analysis showed that distant metastasis was an independent risk factor affecting the prognosis of MBC.…”

Section: Discussionsupporting

confidence: 93%

“…Bone metastasis rates were higher than in previous studies, with bone metastasis rates of 50% in metastatic MBC patients in a previous German study, 33 and 75% in another study based on the SEER database. 34 However, the highest incidence of bone metastasis and the lowest incidence of brain metastasis were consistent with previous studies. Although the rate of single liver metastasis was only 3%, it seems that the rate of liver metastasis combined with other metastases was not low, accounting for 13% of the total metastases, and also in brain metastases (1% versus 10%).…”

Section: Discussionsupporting

confidence: 92%

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Metastasis pattern and prognosis of male breast cancer patients in US: a population-based study from SEER database

Xie

Ying

et al. 2019

Ther Adv Med Oncol

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Background: The aims of this study were to analyze the metastasis pattern and prognosis of male breast cancer (MBC) and compare it with female breast cancer (FBC), and to determine the independent factors affecting the prognosis of MBC patients. Methods: Metastatic MBC diagnosed in the Surveillance, Epidemiology and End results (SEER) database from 2010 to 2015 were selected. Chi-squared test was used to compare clinicopathological characteristics. Survival differences were compared by Kaplan–Meier analysis. Cox proportional hazard model was used to determine the prognostic factors affecting overall survival. Results: A total of 2754 MBC patients were identified, of which 196 had distant metastasis. Compared with nonmetastatic MBC, metastatic MBC patients had a higher proportion of <60 years old and grade III–IV, and were more likely to receive chemotherapy and radiotherapy, while the proportion of surgery, central portion of the breast, and Her2–/HR+ was lower. Compared with metastatic FBC, metastatic MBC patients had a higher proportion of ⩾60 years old, central portion of the breast, surgery, simultaneous bone and lung metastasis, while the proportion of Her2+/HR–, triple negative, liver metastasis only, and simultaneous bone and liver metastasis was lower. MBC patients with lung alone, bone alone, and simultaneous lung and bone metastasis had a higher hazard ratio (2.41; 3.06; 2.52; p < 0.0001) compared with nonmetastatic patients. Conclusions: Compared with nonmetastatic MBC patients, metastatic MBC patients had unique clinicopathological features, and were also different from metastatic FBC patients. However, there was no difference in prognosis between metastatic MBC and FBC patients. Distant metastasis was an independent risk factor for the prognosis of MBC patients.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Metastasis pattern and prognosis of male breast cancer patients in US: a population-based study from SEER database

Xie

Ying

et al. 2019

Ther Adv Med Oncol

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“…Nevertheless, previous reports indicate that compliance with these guidelines is generally lower for male patients. 22,23 Research on current guidelines compliance and the development of sex-specific guidelines is warranted.…”

Section: Discussionmentioning

confidence: 99%

“…However, results on stage-specific survival have been inconsistent. Some studies suggested the sex disparity in OS was only evident for patients with early-stage but not advanced-stage disease. In contrast, studies by El-Tamer et al and Miao et al showed no significant differences in stage-specific survival between male and female patients with breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Overall Mortality After Diagnosis of Breast Cancer in Men vs Women

et al. 2019

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IMPORTANCE Survival differences between male and female patients with breast cancer have been reported, but the underlying factors associated with the disparity have not been fully studied. This understanding is fundamental to developing strategies for cancer treatment and survivorship care. OBJECTIVE To compare mortality between male and female patients with breast cancer and quantitatively evaluate the factors associated with sex-based disparity in mortality. DESIGN, SETTING, AND PARTICIPANTS This large, nationwide, registry-based cohort study used the National Cancer Database to identify and obtain data on patients who

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“…Historically, it has been acknowledged that MBC presents distinct profiles of clinicopathological features and prognostic outcomes in comparison with female breast cancer (FBC) ( 4 – 6 ). However, the majority of treatments for MBC are extrapolated from the standardized therapeutics of FBC ( 7 ), with limited consideration of the specific biological features as well as clinical presentations of male patients with breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Sex-Based Heterogeneity in the Clinicopathological Characteristics and Prognosis of Breast Cancer: A Population-Based Analysis

Wang

2021

Front. Oncol.

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PurposeTo better understand the differences in clinicopathological features and prognosis between male breast cancer (MBC) and female breast cancer (FBC).Material and MethodsData on patients diagnosed with breast cancer from January 1, 2010, to December 31, 2016, were obtained from the Surveillance, Epidemiology, and End Results database. Selected patients were classified into MBC and FBC, of which population demographics and clinicopathological features at baseline were successively extracted for analysis. Comparative analysis was performed to explore the differences in baseline characteristics, followed by propensity-score matching to calibrate the objective distinctions for adjusted analysis. Survival analysis was carried out to investigate divergences presented in prognosis from the two cohorts, and risk factors for prognosis were successively identified using univariate and multivariate COX regression analyses.ResultsA total of 407341 individuals were eligible, including 3111 MBC (0.7%) and 404230 FBC (99.3%) patients. Comparatively, patients with MBC tended to be older at diagnosis, with a higher confirmation of ductal carcinoma, a higher histological grade, a higher TNM stage, a higher proportion of luminal-like subtype, a higher rate of lung metastasis, a lower incidence of liver involvement, and a lower rate of surgical, radiation, and chemotherapeutic delivery. The overall prognosis of MBC was significantly worse than that of FBC, with a decreasing divergence both in median overall survival (65.5 months vs. 72.7 months, P<0.0001) and median breast cancer-specific survival (75.4 months vs. 77.8 months, P<0.0001). However, these discrepancies were not consistent among patients from different subgroups stratified by molecular subtype, age at diagnosis, or disease stage.ConclusionIn this study, sex-based heterogeneity in clinicopathological characteristics and prognostic profiles was observed in the overall population of patients with breast cancer and was significantly variable among different subgroups. A male-specific design with reasonable endpoints for a clinical trial protocol will be warranted in the future.

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Men and women show similar survival outcome in stage IV breast cancer

Cited by 7 publications

References 33 publications

Metastasis pattern and prognosis of male breast cancer patients in US: a population-based study from SEER database

Metastasis pattern and prognosis of male breast cancer patients in US: a population-based study from SEER database

Overall Mortality After Diagnosis of Breast Cancer in Men vs Women

Sex-Based Heterogeneity in the Clinicopathological Characteristics and Prognosis of Breast Cancer: A Population-Based Analysis

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