Overall Mortality After Diagnosis of Breast Cancer in Men vs Women

Wang, Fei; Shu, Xiang; Meszoely, Ingrid M.; Pal, Tuya; Mayer, Ingrid A.; Yu, Zhengping; Wang, Zheng

doi:10.1001/jamaoncol.2019.2803

Cited by 128 publications

(123 citation statements)

References 27 publications

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“…Although there is limited evidence about the indications for adjuvant radiation therapy in MBC patients, the indications generally recommended for MBC patients are similar to those recommended for FBC patients to prevent local recurrence. 15,17,24 We acknowledge that several factors affect the decision on whether adjuvant radiation therapy is necessary in both MBC and FBC patients. However, even after adjusting for factors such as the type of surgical procedure, combined stage, and age, we showed that gender was a determinant of adjuvant radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and practice patterns for male breast cancer compared with female breast cancer in Japan

et al. 2020

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Male breast cancer (MBC) is rare, representing fewer than 1% of all breast cancer in the United States 1 ; however, recent trends show increased incidence. 2 Epidemiological differences in male and female breast cancer (FBC), such as an older age and a higher stage at diagnosis in MBC patients have been noted. Additionally, there is a higher chance of MBC being hormone receptor-positive and a lower chance of exhibiting human epidermal growth factor receptor-2 (HER2) overexpression. 2-5 Consequently, cancer treatment differs between MBC and FBC patients. A study citing the National Cancer

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Section: Discussionmentioning

confidence: 99%

Epidemiology and practice patterns for male breast cancer compared with female breast cancer in Japan

et al. 2020

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“…Furthermore, male breast cancers are usually diagnosed at advanced stages 3 or 4, imputable mainly to a lack of awareness [11] . The 5-year overall survival rate is also lower for men (77.6%) when compared to women (86.4%) [12] .…”

Section: Incidence Of Breast Cancersmentioning

confidence: 91%

Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses

Taurin

Alkhalifa

2020

Neoplasia

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Highlights Breast cancer is a complex disease arising from the association and cumulation of multiple genetic alterations and environmental factors likely to alter cellular functions. The implication of stem cells in breast cancer’s origin and development has been debated for many years. Analogies between stem cells and cancer cells can be drawn on many levels. Importantly not all cancer cells are stem cells or exhibit properties similar to stem cells. There is no universal cell surface marker of the breast cancer stem cells, imputable to the diversity of the cell of origin, the heterogeneity and fluidity of the microenvironments, and a plethora of possible mutational events. Breast cancer stem cell targeting should hold a great promise for preventing metastasis, reducing the risk of drug resistance, and decreasing recurrence. However, only a few clinical trials assess the effectiveness of treatments on this specific cancer cell population. Additional considerations for the targeting of breast cancer stem cells need to be given to the tumor microenvironment. It is known to promote self-renewal, plasticity, and resistance to treatments. The fate of breast cancer stem cells is indissociable from its environment.

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“…The receptor status of male breast cancers is most commonly estrogen receptor (ER) and progesterone receptor (PR) positive and HER2 (human epidermal growth factor receptor 2) negative [1,6]. Men with breast cancer are older (median age of 63 years), present with a larger tumor size (> 2 cm), more frequently have nodal involvement, exhibit more advanced stage, and have poorer stage for stage overall survival compared to women [6,8,9]. Approximately 40% of men present with stage III or IV disease [10].…”

Section: Introductionmentioning

confidence: 99%

Image-based screening for men at high risk for breast cancer: Benefits and drawbacks

et al. 2020

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Male breast cancer is a rare malignancy. Due to low prevalence and limited data to support male breast cancer screening, there are currently no recommendations for image-based screening in asymptomatic men and few recommendations for men at high risk for breast cancer. However, symptomatically diagnosed cancers in men are typically advanced, suggesting that earlier detection may improve outcomes. In this article we briefly review the risk factors for male breast cancer and discuss the potential benefits and possible drawbacks of routine image-based screening for men at high risk for breast cancer.

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Overall Mortality After Diagnosis of Breast Cancer in Men vs Women

Cited by 128 publications

References 27 publications

Epidemiology and practice patterns for male breast cancer compared with female breast cancer in Japan

Epidemiology and practice patterns for male breast cancer compared with female breast cancer in Japan

Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses

Image-based screening for men at high risk for breast cancer: Benefits and drawbacks

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