Epidemiology and practice patterns for male breast cancer compared with female breast cancer in Japan

Ishii, Takefumi; Nakano, Eriko; Watanabe, Toshi; Higashi, Takahiro

doi:10.1002/cam4.3267

Cited by 15 publications

(11 citation statements)

References 28 publications

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“…In comparison with women, men with BC tend to be diagnosed at an older age, for both early and advanced disease, with a median age at diagnosis ranging between 60 and 70 years, compared to 55–60 years in women [ 12 , 26 , 27 , 28 ]. Black men are more likely to be younger when diagnosed and have worse survival rates than their White counterparts [ 29 , 30 , 31 ].…”

Section: Epidemiology and Non-genetic Risk Factors For Mbcmentioning

confidence: 99%

“…At diagnosis, men with BC tend to present a more advanced stage of the disease when compared with women, usually with tumors >2.0 cm and positive axillary lymph nodes [ 26 , 27 ]. Many factors can explain the late diagnosis in men: absence of screening programs, lack of awareness about the condition by male population, embarrassment due to a stigmatization of the disease, and misjudgment by primary care physicians [ 20 , 46 , 47 , 48 ].…”

Section: Mbc Disease Characteristicsmentioning

confidence: 99%

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Genetic Landscape of Male Breast Cancer

Campos

Rouleau

Torrezan

et al. 2021

Cancers

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Male breast cancer (MBC) is now considered molecularly different from female breast cancer (FBC). Evidence from studies indicates that common genetic and epigenetic features of FBC are not shared with those diagnosed in men. Genetic predisposition is likely to play a significant role in the tumorigenesis of this rare disease. Inherited germline variants in BRCA1 and BRCA2 account for around 2% and 10% of MBC cases, respectively, and the lifetime risk of breast cancer for men harboring BRCA1 and BRCA2 mutations is 1.2% and 6.8%. As for FBC, pathogenic mutations in other breast cancer genes have also been recently associated with an increased risk of MBC, such as PALB2 and CHEK2 mutations. However, while multigene germline panels have been extensively performed for BC female patients, the rarity of MBC has resulted in limited data to allow the understanding of the magnitude of risk and the contribution of recently identified moderate penetrance genes of FBC for MBC predisposition. This review gathers available data about the germline genetic landscape of men affected by breast cancer, estimated risk associated with these genetic variants, and current guidelines for clinical management.

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Section: Epidemiology and Non-genetic Risk Factors For Mbcmentioning

confidence: 99%

Section: Mbc Disease Characteristicsmentioning

confidence: 99%

Genetic Landscape of Male Breast Cancer

Campos

Rouleau

Torrezan

et al. 2021

Cancers

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“…Unlike the mature and profound management of female breast cancer (FBC) (Emens, 2018; McDonald et al, 2016), the main diagnosis and treatment of MBC are extrapolated from our knowledge of female counterpart. According to many researches, MBC patients were at later stage when they were diagnosed, they were older than female patients and less likely to receive standard therapy (Giordano, 2005; Ishii et al, 2020), the improvement of survival for them was poorer than female patients (Anderson et al, 2010; Ellington et al, 2020). Metastasis is the main culprit that leads to poor prognosis (DeSantis et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram to predict survival for advanced male breast cancer

2022

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Male breast cancer is a rare disease. Many experiences of male breast cancer were derived of female breast cancer. However, there are huge differences between two groups. We conducted this study to find a reliable prognostic model for advanced male breast cancer. The cohort was selected from the Surveillance, Epidemiology, and End Results database. The enrolled patients were randomly divided into training and validation group. The univariate and multivariate analyses were used for prognostic assessment and a nomogram was built. Calibration curves and concordance index were compiled to determine predictive and discriminatory capacity. The timedependent receiver operating curves and the decision curve analysis was used to verify the model's ability. Two hundred and eighty individuals were enrolled. The cumulative rates of 1-, 3-and 5-year overall survival (OS) rates were 98.6%, 72% and 57.9%. The C-indexes for OS were 0.835 (95%CI, 0.777-0.893) in the training group and 0.765 (95%CI, 0.668-0.862) in the validation group. The calibration curves confirmed the consistency of the nomogram both in the training and validation group.The time-dependent receiver operating curves and decision curve analysis demonstrated that the nomogram had better prediction capacity than TNM stage system for advanced male breast cancer. The nomogram we built was a reliable and solid predictive model.

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“…Another study from Turkey reported that the median age at presentation was 62 years (range, 35-90 years) [57]. The mean age of the male breast cancer incidence was 63.3 years in Japanese males; however, at diagnosis, the mean age of Japanese MBC patients was 70 years [58,59], whereas in US MBC patients, the mean age at diagnosis 10 International Journal of Breast Cancer was 67 years [60]. In the Southern China region, the age at diagnosis in male patients was 64.5 years, whereas in the northern China region, it is 62 years (range, 24-84 years) [61,62].…”

Section: Discussionmentioning

confidence: 99%

Profile of Male Breast Cancer in Makkah Region of Saudi Arabia: A 4-Year Retrospective Analysis of Radiology and Histopathology

Saeed

Abdulshakour

Bantan

et al. 2022

International Journal of Breast Cancer

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Background. Mammography is a method widely used for the diagnosis of breast disorders in women and may help detect breast cancer in its early stages. Male breast cancer often remains undiagnosed or is poorly controlled until serious complications arise; therefore, the use of screening methods is needed to help with early diagnosis. Methods. From a total of 1,667 registered mammography cases screened, 17 male breast disease cases were included in this study. Mammography and ultrasound data were analyzed by Statistical Package of Social Sciences v.22 (SPSS). Diagnosis was made following biopsy in suspicious cases, and histopathological and immunological findings of all such patients were obtained for final diagnosis. Results. The mean age of the patients was 35 years (range, 14-70 years); 17.6% of the cases were aged 37 yrs, and 2 cases were aged 51 and 52 yrs. Of the 17 cases, 11 had breast lesions, and skin thickening was observed in only 1 case. The different patterns of lesions detected were asymmetry of the parenchyma, mastitis, and hamartoma (n=1each), malignant lesions (n=2), and gynecomastia (n=6). According to the BI-RADS categorization, 8 cases were benign, one case was probably benign, and 2 cases were likely malignant. In the 2 cases with malignant lesions, pathological diagnosis was made after hematoxylin and eosin and immunocytochemistry examination as invasive ductal carcinoma (IDC) of no special type (NST), grade II and grade III. Conclusions. Most breast lesions in this study population were benign, while IDC was the most common malignancy encountered. Mammography is currently the most accurate and cost-effective method for detecting breast lesions. The findings of our study may help increase awareness of male breast cancer and encourage Saudi men at risk to perform self-breast exam and undergo routine breast screening.

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Epidemiology and practice patterns for male breast cancer compared with female breast cancer in Japan

Cited by 15 publications

References 28 publications

Genetic Landscape of Male Breast Cancer

Genetic Landscape of Male Breast Cancer

Development and validation of a nomogram to predict survival for advanced male breast cancer

Profile of Male Breast Cancer in Makkah Region of Saudi Arabia: A 4-Year Retrospective Analysis of Radiology and Histopathology

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