Metastasis pattern and prognosis of male breast cancer patients in US: a population-based study from SEER database

Abstract

Background: The aims of this study were to analyze the metastasis pattern and prognosis of male breast cancer (MBC) and compare it with female breast cancer (FBC), and to determine the independent factors affecting the prognosis of MBC patients. Methods: Metastatic MBC diagnosed in the Surveillance, Epidemiology and End results (SEER) database from 2010 to 2015 were selected. Chi-squared test was used to compare clinicopathological characteristics. Survival differences were compared by Kaplan–Meier analysis. Cox proportional hazard model was used to determine the prognostic factors affecting overall survival. Results: A total of 2754 MBC patients were identified, of which 196 had distant metastasis. Compared with nonmetastatic MBC, metastatic MBC patients had a higher proportion of <60 years old and grade III–IV, and were more likely to receive chemotherapy and radiotherapy, while the proportion of surgery, central portion of the breast, and Her2–/HR+ was lower. Compared with metastatic FBC, metastatic MBC patients had a higher proportion of ⩾60 years old, central portion of the breast, surgery, simultaneous bone and lung metastasis, while the proportion of Her2+/HR–, triple negative, liver metastasis only, and simultaneous bone and liver metastasis was lower. MBC patients with lung alone, bone alone, and simultaneous lung and bone metastasis had a higher hazard ratio (2.41; 3.06; 2.52; p < 0.0001) compared with nonmetastatic patients. Conclusions: Compared with nonmetastatic MBC patients, metastatic MBC patients had unique clinicopathological features, and were also different from metastatic FBC patients. However, there was no difference in prognosis between metastatic MBC and FBC patients. Distant metastasis was an independent risk factor for the prognosis of MBC patients.

Management and outcome of male metastatic breast cancer in the national multicenter observational research program Epidemiological Strategy and Medical Economics (ESME)

“…Intriguingly, a recent analysis of 196 metastatic male BC cases confirms this specific pattern of metastasis distribution compared with women with no clear explanation. 12 Recently, an international program has been launched to improve male breast cancer characterization. This three-part program includes the retrospective collection of clinical information and male breast cancer tumor tissue over 20 years, a prospective register of newly diagnosed cases over a 30-month period, and prospective clinical studies to optimize these patients’ management.…”

“…This rate is lower than reported for women and not explained by the presence of visceral crisis reflecting the pattern distribution of metastases. 12 The assumption that the ET given to women is less effective in men is a possible explanation as no prospective randomized data evaluating tamoxifen in metastatic male BC have been reported. However, we show that the median PFS achieved by frontline ET alone is similar in men and women.…”

Male Breast Cancer with Ureteral Metastasis: A Case Report

“…Common metastasis site of breast cancer includes axillary lymph nodes, lung, liver, bone and brain while ureteral metastasis is very rare [7]. Here we report an interesting male breast cancer case with ureteral metastasis.…”

Male Breast Cancer with Ureteral Metastasis: a case report

“…Breast cancer commonly metastasis to lymph nodes, lung, liver, bone or brain, and only few cases were reported metastasis to other sites such as intestine or ureter, which may be easily misdiagnosed [7]. In this case, the patient developed a symptom of hematuresis, which was considered urinary tract infection or primary tumors at rst.…”

“…Common metastasis site of breast cancer includes axillary lymph nodes, lung, liver, bone and brain while ureteral metastasis is very rare [7]. Here we report a male breast cancer case with ureteral metastasis.…”