Memory performance of young and old subjects related to their erythrocyte characteristics

Danon, D.; Bologna, Nancy B.; Gavendo, S

doi:10.1016/0531-5565(92)90055-5

Cited by 17 publications

(21 citation statements)

References 16 publications

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“…Whereas ALT is predominantly of hepatic origin, AST can be found in tissues outside the liver, such as the brain 49 . Regarding MCV, though some studies show that erythrocyte volume may impact cognition 50 , we were not able to replicate such a finding in this analysis.…”

Section: Discussioncontrasting

confidence: 82%

Association of Alcohol Use Biomarkers and Cognitive Performance in Veterans With Problematic Alcohol Use and Posttraumatic Stress Disorder: Data From the Mind Your Heart Study

Kalapatapu

Neylan

Regan

et al. 2014

Journal of Addictive Diseases

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We conducted a study of alcohol use biomarkers and cognitive performance among 85 veterans with problematic alcohol use and posttraumatic stress disorder (PTSD). All analyses were adjusted for demographics, depression, anxiety, and PTSD symptoms. Elevated levels of aspartate aminotransferase (AST) were associated with worse performance on the Trail Making Test Part A and Hopkins Verbal Learning Test. Two other biomarkers were not associated with any neurocognitive measures. Indirect alcohol use biomarkers (e.g., AST) may have a specific role in identifying those veterans with problematic alcohol use and PTSD who show a change in psychomotor speed and immediate verbal memory performance.

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Section: Discussioncontrasting

confidence: 82%

Association of Alcohol Use Biomarkers and Cognitive Performance in Veterans With Problematic Alcohol Use and Posttraumatic Stress Disorder: Data From the Mind Your Heart Study

Kalapatapu

Neylan

Regan

et al. 2014

Journal of Addictive Diseases

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“…Approaching significance, the MCV predicting BART performance is interesting. Though MCV may appear to be unrelated to cognition, some studies have shown that erythrocyte volume may influence cognition, 54 and that MCV can predict delirium after surgery. 23 MCV has also been associated with gray matter decline 50 and ventricular enlargement.…”

Section: Discussionmentioning

confidence: 99%

“…55 One possibility is that the increased erythrocyte volume, which is found in alcohol dependence 19 and during times of stress, 56,57 may lead to erythrocytes having difficulty passing through narrow brain capillaries and subsequently affecting cognitive performance. 54 …”

Section: Discussionmentioning

confidence: 99%

Alcohol Use Biomarkers Predicting Cognitive Performance: A Secondary Analysis in Veterans With Alcohol Dependence and Posttraumatic Stress Disorder

et al. 2013

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Objective We conducted a secondary analysis of baseline data from a recently completed pharmacological pilot clinical trial among 30 veterans with alcohol dependence and posttraumatic stress disorder (PTSD). This trial included baseline measures of alcohol use biomarkers, both indirect (carbohydrate-deficient transferrin, GGT [γ-glutamyltransferase], mean corpuscular volume, AST [aspartate aminotransferase], alanine aminotransferase) and direct (ethyl glucuronide, ethyl sulfate), as well as neurocognitive measures (Trail Making Test parts A and B, Hopkins Verbal Learning Test—Revised, Balloon Analogue Risk Task, Delay Discounting Task). Methods Two regression models were estimated and tested for each neurocognitive measure (dependent measure). The first model included the alcohol use biomarker alone as the predictor. The second model included the alcohol use biomarker along with the following 3 additional predictors: Beck Depression Inventory, Clinician-Administered PTSD Scale, and receiving medications. Results In both models, the indirect biomarkers, such as GGT and AST, significantly predicted performance on the Hopkins Verbal Learning Test—Revised %Retention. GGT alone significantly predicted performance on the Trail Making Test part A. Conclusions Indirect alcohol use biomarkers may have a specific role in identifying those veterans with alcohol dependence and PTSD who have impaired cognitive performance. However, direct alcohol use biomarkers may not share such a role.

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“…Younger RBCs tend to have larger volumes, as measured by MCV, soon after they are released into circulation as reticulocytes, and their volume tends to decline. 6,8 The life span of RBCs is shorter in older adults, and the production of RBCs increases in compensation. 8,9 A higher percentage of young cells are found in the circulation, leading to higher MCV.…”

Section: To the Editormentioning

confidence: 99%

Age‐related Changes in Mean Corpuscular Volume in Adult Whites and African Americans

Gamaldo

Ferrucci

Rifkind

et al. 2011

J American Geriatrics Society

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Memory performance of young and old subjects related to their erythrocyte characteristics

Cited by 17 publications

References 16 publications

Association of Alcohol Use Biomarkers and Cognitive Performance in Veterans With Problematic Alcohol Use and Posttraumatic Stress Disorder: Data From the Mind Your Heart Study

Association of Alcohol Use Biomarkers and Cognitive Performance in Veterans With Problematic Alcohol Use and Posttraumatic Stress Disorder: Data From the Mind Your Heart Study

Alcohol Use Biomarkers Predicting Cognitive Performance: A Secondary Analysis in Veterans With Alcohol Dependence and Posttraumatic Stress Disorder

Age‐related Changes in Mean Corpuscular Volume in Adult Whites and African Americans

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