Age‐related Changes in Mean Corpuscular Volume in Adult Whites and African Americans

Gamaldo, Alyssa A.; Ferrucci, Luigi; Rifkind, Joseph M.; Zonderman, Alan B.

doi:10.1111/j.1532-5415.2011.03583.x

Cited by 21 publications

(19 citation statements)

References 9 publications

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“…When we analyzed the results considering the BMI, we found that in people with abnormal BMI some of the platelet parameters (MPV, PCT and RDW) deviated from RIs, probability due to the fact that those factors have been linked with an increased risk of microvascular blood flow resistance [40] and vascular mortality [41]. Regarding chronologic age, we found an increased value of MCV and MCH with aging in Malians, in both white and black people, as already reported in literature [42, 43]. In fact, it has been suggested that MCV increases gradually during early adulthood, levels off around middle adulthood,to rise again in old age.…”

Section: Discussionsupporting

confidence: 83%

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Baseline haematological and biochemical reference values for healthy male adults from Mali

Vita

Miglietta²,

Maurizio³

et al. 2019

Pan Afr Med J

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Introduction Haematological reference values are very important for diagnostic orientation and treatment decision. The aim of this study was to establish haematological reference values for Malian healthy adults. Methods A cross-sectional study including 161 male Malians aged between 19 and 54 years old was performed. Median and reference ranges were calculated for haematological and biochemical parameters. Parametric student's t-test was used to determine any statistically significant differences by age, smoker status, body mass index (BMI) and occupation. Ranges were further compared with those reported for other African, Afro-American and Caucasian populations. Results Increased levels of MCV, MCH, PLT and EOS were found in younger Malians who had abnormal BMI and altered platelets parameters. Notably, significantly lower eosinophil and monocyte counts were observed in Malians compared to Europeans The smoking status did not seem to directly affect RIs. Conclusion This is the first study to determine normal laboratory parameters in Malian adult males. Our results underscore the necessity of establishing region-specific clinical reference ranges that would allow clinicians and practitioners to manage laboratory tests, diagnosis and therapies. These data are useful not only for the management of patients in Mali, but also to support European and American clinicians in the health management of asylum seekers and migrants from Mali.

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Section: Discussionsupporting

confidence: 83%

“…In fact, it has been suggested that MCV increases gradually during early adulthood, levels off around middle adulthood,to rise again in old age. Thus, such fluctuations might be associated with differences in red blood cell survival [42].…”

Section: Discussionmentioning

confidence: 99%

Baseline haematological and biochemical reference values for healthy male adults from Mali

Vita

Miglietta²,

Maurizio³

et al. 2019

Pan Afr Med J

View full text Add to dashboard Cite

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“…In addition, these findings expand upon the existing cognitive aging literature by introducing a potentially new area of research that explores how age‐related physiological changes in red blood cells might explain inter‐ and intra‐individual differences in cognitive performance. For example, given that MCV tends to be lower in African Americans than whites, whether changes in MCV may explain differences between age‐related changes in cognition between whites and African Americans is currently being explored.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Mean Corpuscular Volume and Cognitive Performance in Older Adults

Gamaldo

Ferrucci

Rifkind

et al. 2013

J American Geriatrics Society

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OBJECTIVES To examine the relationship between erythrocyte mean corpuscular volume (MCV) and cognitive performance over time. DESIGN Longitudinal. SETTING Sample from the Baltimore Longitudinal Study of Aging (BLSA) PARTICIPANTS The sample consisted of 827 participants from the Baltimore Longitudinal Study of Aging (BLSA; M age = 67; range = 50 – 96). MEASUREMENTS MCV and several other blood indices were measured including hemoglobin, iron, ferritin, vitamin B12, folate, white blood cell count, albumin and erythrocyte sedimentation rate. Cognitive performance was examined using neuropsychological measures of visual memory, verbal memory, language, attention, executive function and global mental status. RESULTS High MCV levels were significantly associated with lower global mental status even after adjusting for potential confounders. High MCV levels were also significantly associated with accelerated rates of decline on tasks of global mental status, long delay memory, and attention even after adjusting for potential confounders. CONCLUSION Our findings confirm a previous observation that larger erythrocytes in older adults are associated with poorer cognitive function. The relationship between MCV and cognition does not appear to be explained by anemia and inflammation. Further research is needed to clarify the mechanisms behind this association.

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“…Macrocytosis is more common in elderly patients, and the increased MCV could be reflected by the shorter lifespan of the red blood cells (RBCs) necessitating increased production of younger cells (reticulocytes), leading to the macrocytosis . It can also reflect an advanced and aggressive disease biology in MM.…”

Section: Discussionmentioning

confidence: 99%

Hematopoietic score predicts outcomes in newly diagnosed multiple myeloma patients

et al. 2019

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Risk stratification of multiple myeloma (MM) at diagnosis is critical. We examined the ability of hematopoietic indices including mean corpuscular volume (MCV), hemoglobin (Hgb), and platelet (Plt) to predict outcomes. This was a retrospective study of patients treated at Mayo Clinic between January 2004 and April 2018. We incorporated three variables (Hgb < 10 g/dL, Plt < 150 × 10 9 /L, and MCV > 96 fL), assigning a score of 1 to each. We identified 1540 newly diagnosed MM patients, of whom 707 (46%) had a score of 0, 513 (33%) had a score of 1, 260 (17%) had a score of 2, and 60 (4%) had a score of 3. The score risk stratified patients into four groups with differing survivals. The median PFS was 32.3 months for score 0, 24.8 months for score 1, 21.7 months for score 2, and 18.3 months for score 3, for P < .001. The median OS was 80.7 months for score 0, 59.9 months for score 1, 51.7 months for score 2, and 31.3 months for score 3, P < .0001. Predictors of OS on the multivariable analysis were age ≥ 65 (HR, 1.93; P < .0001), R-ISS stage (1-2 vs 3) (HR, 0.48; P < .0001), and hematopoietic score (0-2 vs 3) (HR, 0.51; P = .006). A hematopoietic score can predict survival in newly diagnosed myeloma patients.

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Age‐related Changes in Mean Corpuscular Volume in Adult Whites and African Americans

Cited by 21 publications

References 9 publications

Baseline haematological and biochemical reference values for healthy male adults from Mali

Baseline haematological and biochemical reference values for healthy male adults from Mali

Relationship Between Mean Corpuscular Volume and Cognitive Performance in Older Adults

Hematopoietic score predicts outcomes in newly diagnosed multiple myeloma patients

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