Association of Alcohol Use Biomarkers and Cognitive Performance in Veterans With Problematic Alcohol Use and Posttraumatic Stress Disorder: Data From the Mind Your Heart Study

Kalapatapu, Raj K.; Neylan, Thomas C.; Regan, Mathilda; Cohen, Beth E.

doi:10.1080/10550887.2014.909701

Cited by 2 publications

(1 citation statement)

References 50 publications

(43 reference statements)

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“…A previous study reported that patients with problematic alcohol use and posttraumatic stress disorder showed the association between elevated levels of aspartate aminotransferase and trail making A test. 20 But in the present study, clinical datum did not show any relationship with cognitive functioning.…”

Section: Discussioncontrasting

confidence: 83%

Association between insulin and executive functioning in alcohol dependence: a pilot study

Han¹,

Bae²,

Won³

et al. 2015

NDT

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Alcohol dependence is a disorder ascribable to multiple factors and leads to cognitive impairment. Given that insulin dysregulation can cause cognitive impairment, patients with alcohol dependence are likely to develop insulin dysregulation such as that in diabetes. The purposes of this study are to identify an association between cognitive functioning and insulin and to investigate insulin as the biomarker of cognitive functioning in alcohol-dependent patients. Serum insulin levels were measured and cognitive functions were assessed in 45 patients with chronic alcoholism. The Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K), a battery of cognitive function tests, was used to assess cognitive functioning. Serum insulin levels were not significantly correlated with most CERAD-K scores, but there was a significant negative correlation with scores on the Trail Making Test B, which is designed to measure executive functioning. Lower serum insulin levels were associated with slower executive functioning responses on the Trail Making Test B, suggesting that executive functioning may be in proportion to serum insulin levels. Thus, in patients with alcohol dependence, insulin level is associated with cognitive functioning. In addition, the present findings suggest that insulin level is a potential biomarker for determining cognitive functioning.

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Section: Discussioncontrasting

confidence: 83%

Association between insulin and executive functioning in alcohol dependence: a pilot study

Han¹,

Bae²,

Won³

et al. 2015

NDT

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Does trauma exposure predict prescription drug problems beyond the contribution of post-traumatic stress disorder and depression? An analysis of the Mind Your Heart cohort study

Kalapatapu

Dannenbaum

Harbison

et al. 2017

Journal of Addictive Diseases

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Background It is not clear from prior studies whether trauma exposure predicts substance use problems independent of psychiatric comorbidities. Most prior studies were cross-sectional in nature, and none focused on prescription drug problems. Aims To address this gap in the literature, this paper is a secondary analysis of veterans from the Mind Your Heart prospective cohort study. The primary research question is whether trauma exposure predicts prescription drug problems even after controlling for major psychiatric symptoms, such as posttraumatic stress disorder and depression. Methods Multinomial logistic regression was used to assess whether the 10-item lifetime Brief Trauma Questionnaire (e.g., serious car accidents, war traumas, life-threatening illness, natural disasters, physical or sexual abuse) predicts prescription drug problems as determined by a self-report categorical question (3 answer choices) over a 4-year follow-up time period (n = 661 [100%] at year 1; 83.4% at year 2; 85.9% at year 3; 78.2% at year 4). Results Trauma exposure was positively associated with prescription drug problems in unadjusted and age-, sex-, and race-adjusted analyses at follow-up. After accounting for PTSD (PTSD Checklist-17 Civilian Version) and depression (Patient Health Questionnaire-9) symptoms, trauma exposure was no longer associated with prescription drug problems at all time points (relative risk ratios range 0.91–1.47). These results were robust to different missing data strategies. Discussion Trauma exposure was not associated with prescription drug problems over a 4-year follow-up in a prospective cohort study of veterans. Future directions include detailed measures of prescription drug problems and recruitment from community sites.

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Association of Alcohol Use Biomarkers and Cognitive Performance in Veterans With Problematic Alcohol Use and Posttraumatic Stress Disorder: Data From the Mind Your Heart Study

Cited by 2 publications

References 50 publications

Association between insulin and executive functioning in alcohol dependence: a pilot study

Association between insulin and executive functioning in alcohol dependence: a pilot study

Does trauma exposure predict prescription drug problems beyond the contribution of post-traumatic stress disorder and depression? An analysis of the Mind Your Heart cohort study

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