Memory Function in Patients with Parkinson's Disease: In Relation to Neuropsychological Tests and Cerebral Blood Flow.

Shibuya, Naomi; Tachibana, Hisao; Kawabata, Keita; Sugita, Minoru

doi:10.3143/geriatrics.38.193

Cited by 4 publications

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“…Although the effect sizes for the deficits in recognition and prospective memory may not be clinically significant, they may be of theoretical interest, helping to establish how the central nervous system deteriorates as the disease progresses. The deficits in recognition memory are particularly noteworthy as it is widely held that recognition memory remains largely intact in PD (Brown & Marsden, 1988;Emre, 2003;Knight, 1992;Shibuya et al, 2001;Taylor et al, 1988). The finding that early-stage PD participants had no deficit in recognition at the easy level of the task is also important, as it may help to explain some of the discrepancies in the literature concerning the existence of deficits in recognition memory among PD patients.…”

Section: Discussionmentioning

confidence: 91%

“…Beyond this, however, there is less agreement. It is widely held that, although recall is impaired in people with PD, recognition memory is relatively normal (Breen, 1993;Brown & Marsden, 1988;Emre, 2003;Ivory, Knight, Longmore, & Caradoc-Davies, 1999;Knight, 1992;Shibuya, Tachibana, Kawabata, & Sugita, 2001;Taylor, Saint-Cyr, & Lang, 1988). Three studies (Flowers, Pearce, & Pearce, 1984;Lees & Smith, 1983;Taylor, Saint-Cyr, & Lang, 1986) appear to have been instrumental in establishing this view.…”

Section: Recognition and Recall In Pdmentioning

confidence: 88%

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Memory Deficits in Parkinson’s Disease

Whittington

Podd

Stewart‐Williams

2006

Journal of Clinical and Experimental Neuropsychology

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The purpose of this study was to investigate deficits in recognition, recall, and prospective memory among Parkinson's disease (PD) patients, and to ascertain whether task difficulty and disease severity moderate these deficits. Comparisons were made between 41 nondemented PD participants, divided into early-stage and advanced-stage groups, and 41 matched controls. PD participants exhibited deficits in recognition, recall, and prospective memory. The advanced-stage PD group produced greater deficits than the early-stage PD group in all tasks, suggesting that these deficits increase in step with overall disease severity. The results of the task difficulty manipulation provide a partial explanation for the inconsistencies in the literature concerning the existence of recognition memory deficits in PD.

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Section: Discussionmentioning

confidence: 91%

Section: Recognition and Recall In Pdmentioning

confidence: 88%

Memory Deficits in Parkinson’s Disease

Whittington

Podd

Stewart‐Williams

2006

Journal of Clinical and Experimental Neuropsychology

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Stroke and neurodegenerative disorders. 4. neurodegenerative disorders11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors(s) or upon any organization with which the author(s) is/are associated.

Bryant

Geis

Moroz

et al. 2004

Archives of Physical Medicine and Rehabilitation

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Sulpiride and mnemonic function: effects of a dopamine D2 receptor antagonist on working memory, emotional memory and long-term memory in healthy volunteers

et al. 2005

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There is now substantial evidence from animal studies showing modulation of cognitive performance after administration of dopaminergic agents. Previous studies have focused on cognitive functions such as working memory (WM), with particular reference to spatial processing. However, to date, studies in normal human volunteers have proved inconsistent. We have therefore tested the effects of the dopamine D2 receptor antagonist sulpiride (400 mg) on WM and learning tasks, including those using auditory, spatial or non-spatial stimuli. A further aim was to explore a broader role of the dopaminergic system in mnemonic function by examining long-term and emotional memory. Eighteen healthy male participants were given a battery of cognitive tests after oral sulpiride or placebo, using the cross-over design. WM was assessed using a spatial searching task, and a task of auditory counting with distraction. Tasks that did not emphasize WM were spatial and non-spatial trial-and-error learning, long-term spatial memory and emotional memory. After dopamine D2 receptor blockade, performance was not impaired on the spatial WM (SWM) task, but was impaired on the auditory counting task with distraction. Sulpiride did not impair, but rather appeared to enhance trial-and-error learning overall. Thus, we were unable to support the notion that dopaminergic modulation preferentially influences spatial over non-spatial processing during learning. In addition, recognition was impaired in the emotional memory task after encoding on drug compared to placebo. These findings question the precise role of dopamine D2 receptor modulation on WM, and highlight the need for sensitive tests to study dopaminergic modulation of emotional processing.

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Memory Function in Patients with Parkinson's Disease: In Relation to Neuropsychological Tests and Cerebral Blood Flow.

Cited by 4 publications

References 0 publications

Memory Deficits in Parkinson’s Disease

Memory Deficits in Parkinson’s Disease

Stroke and neurodegenerative disorders. 4. neurodegenerative disorders11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors(s) or upon any organization with which the author(s) is/are associated.

Sulpiride and mnemonic function: effects of a dopamine D2 receptor antagonist on working memory, emotional memory and long-term memory in healthy volunteers

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