Memory consolidation in children with epilepsy: Does sleep matter?

Sud, Shama; Sadaka, Yair; Massicotte, Colin; Smith, Mary Lou; Bradbury, Laura; Go, Cristina; Weiss, Shelly K.

doi:10.1016/j.yebeh.2013.12.012

Cited by 13 publications

(10 citation statements)

References 14 publications

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“…In addition, the lack of a delayed recall condition without sleep in these studies did not allow for the effect of sleep to be separated from the effect of delay, which is likely significant in a sample with childhood epilepsy . Sud et al performed their study in a similar setting, on patients similar to ours (median spike wave index = 5). Seven of 10 subjects remembered better in the sleep condition; however, the analyzed sample (n = 9) was too small to show an effect of sleep.…”

Section: Discussionmentioning

confidence: 78%

Does sleep benefit memory consolidation in children with focal epilepsy?

et al. 2017

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We have demonstrated that memory consolidation in children with focal epilepsy benefits from sleep, showing the same correlation with slow wave sleep as in healthy children, but an inverse relationship with the interictal discharge load during sleep. This mechanism appears to be increasingly recruited with longer duration of illness, indicating a resilient homeostatic function which may be harnessed to aid learning.

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Section: Discussionmentioning

confidence: 78%

Does sleep benefit memory consolidation in children with focal epilepsy?

et al. 2017

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“…It has frequently been suggested that memory in people with ALF may not benefit from sleep in the same way that it does in healthy people (e.g., Butler et al., 2009, Holmes and Lenck-Santini, 2006, Jansari et al., 2010, Muhlert et al., 2011, Sud et al., 2014, Tramoni et al., 2011, Urbain et al., 2011, Zeman et al., 2013). A recent study of ours, however, demonstrated that sleep can benefit memory retention in people with ALF just as much as it does in healthy control participants (Atherton, Nobre, Zeman, & Butler, 2014).…”

Section: Introductionmentioning

confidence: 99%

Slow wave sleep and accelerated forgetting

Atherton

Nobre

Lázár

et al. 2016

Cortex

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We investigated whether the benefit of slow wave sleep (SWS) for memory consolidation typically observed in healthy individuals is disrupted in people with accelerated long-term forgetting (ALF) due to epilepsy. SWS is thought to play an active role in declarative memory in healthy individuals and, furthermore, electrographic epileptiform activity is often more prevalent during SWS than during wakefulness or other sleep stages. We studied the relationship between SWS and the benefit of sleep for memory retention using a word-pair associates task. In both the ALF and the healthy control groups, sleep conferred a memory benefit. However, the relationship between the amount of SWS and sleep-related memory benefits differed significantly between the groups. In healthy participants, the amount of SWS correlated positively with sleep-related memory benefits. In stark contrast, the more SWS, the smaller the sleep-related memory benefit in the ALF group. Therefore, contrary to its role in healthy people, SWS-associated brain activity appears to be deleterious for memory in patients with ALF.

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“…In children with idiopathic focal epilepsy, overnight performance on a visuospatial task was worse than in healthy controls, and was even further worse in those with a higher calculated spike wave index, but poor performance did not correlate with antiseizure medications (Galer, et al 2015). In another study of children with medically refractory epilepsy in the EMU, there was no evidence of overnight consolidation on a verbal task (Sud, et al 2014). The discrepancy between some of our findings and those of prior studies may be related to the setting, the task being tested (verbal v.s.…”

Section: 0 Discussionmentioning

confidence: 99%

“…In one of the few studies in adult patients, verbal memory consolidation was been shown to correlate with SWS (Deak, et al 2011). Studies analyzing children with focal epilepsy have highlighted an impairment in sleep dependent memory consolidation and the adverse impact of interictal epileptiform discharges (Sud, et al 2014,Galer, et al 2015). Given the limited data available in adults and some conflicting data in children, it would be especially useful to determine whether there is evidence of memory consolidation in the epilepsy monitoring unit to understand the phenomenon better and evaluate factors which may have an influence on this process.…”

Section: Introductionmentioning

confidence: 99%

Sleep-dependent memory consolidation in the epilepsy monitoring unit: A pilot study

Sarkis

Alam

Pavlova

et al. 2016

Clinical Neurophysiology

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Objective We sought to examine whether patients with focal epilepsy exhibit sleep dependent memory consolidation, whether memory retention rates correlated with particular aspects of sleep physiology, and how the process was affected by seizures. Methods We prospectively recruited patients with focal epilepsy and assessed declarative memory using a task consisting of 15 pairs of colored pictures on a 5 × 6 grid. Patients were tested 12 hours after training, once after 12 hours of wakefulness and once after 12 hours that included sleep. EMG chin electrodes were placed to enable sleep scoring. The number and density of sleep spindles were assessed using a wavelet-based algorithm. Results Eleven patients were analyzed age 21–56 years. The percentage memory retention over 12 hours of wakefulness was 62.7% % and over 12 hours which included sleep 83.6 % (p = 0.04). Performance on overnight testing correlated with the duration of slow wave sleep (SWS) (r=+0.63, p <0.05). Three patients had seizures during the day, and another 3 had nocturnal seizures. Day-time seizures did not affect retention rates, while those patients who had night time seizures had a drop in retention from an average of 92% to 60.5%. Conclusions There is evidence of sleep dependent memory consolidation in patients with epilepsy which mostly correlates with the amount of SWS. Our preliminary findings suggest that nocturnal seizures likely disrupt sleep dependent memory consolidation. Significance Findings highlight the importance of SWS in sleep dependent memory consolidation and the adverse impact of nocturnal seizures on this process.

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Memory consolidation in children with epilepsy: Does sleep matter?

Cited by 13 publications

References 14 publications

Does sleep benefit memory consolidation in children with focal epilepsy?

Does sleep benefit memory consolidation in children with focal epilepsy?

Slow wave sleep and accelerated forgetting

Sleep-dependent memory consolidation in the epilepsy monitoring unit: A pilot study

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