Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Infections

Yang, Ruige; Hou, Enhua; Cheng, Wanqing; Yan, Xiaoting; Zhang, Tingting; Li, Shihong; Yao, Hong; Liu, Jifeng; Guo, Yong

doi:10.1021/acs.jmedchem.2c01674

Cited by 70 publications

(31 citation statements)

References 47 publications

(93 reference statements)

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“…The bacterium S. aureus is a Gram-positive bacterium, and it can grow in both aerobic and anaerobic environments as a facultative bacterium [ 6 ]. S. aureus is the most common bacterial pathogen and continues to endanger public health [ 7 , 8 ], causing a variety of symptoms in infected people and being found in normal human flora and the environment. S. aureus can be isolated from the skin and mucous membranes (most often the nasal parts) of healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

Trichoderma-Mediated ZnO Nanoparticles and Their Antibiofilm and Antibacterial Activities

Shobha

Ashwini

Ghazwani

et al. 2023

JoF

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Antimicrobial resistance is a major global health concern and one of the gravest challenges to humanity today. Antibiotic resistance has been acquired by certain bacterial strains. As a result, new antibacterial drugs are urgently required to combat resistant microorganisms. Species of Trichoderma are known to produce a wide range of enzymes and secondary metabolites that can be exploited for the synthesis of nanoparticles. In the present study, Trichoderma asperellum was isolated from rhizosphere soil and used for the biosynthesis of ZnO NPs. To examine the antibacterial activity of ZnO NPs against human pathogens, Escherichia coli and Staphylococcus aureus were used. The obtained antibacterial results show that the biosynthesized ZnO NPs were efficient antibacterial agents against the pathogens E. coli and S. aureus, with an inhibition zone of 3–9 mm. The ZnO NPs were also effective in the prevention of S. aureus biofilm formation and adherence. The current work shows that the MIC dosages of ZnO NPs (25, 50, and 75 μg/mL) have effective antibacterial activity and antibiofilm action against S. aureus. As a result, ZnO NPs can be used as a part of combination therapy for drug-resistant S. aureus infections, where biofilm development is critical for disease progression.

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Section: Introductionmentioning

confidence: 99%

Trichoderma-Mediated ZnO Nanoparticles and Their Antibiofilm and Antibacterial Activities

Shobha

Ashwini

Ghazwani

et al. 2023

JoF

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“…The use of PLA in various medical surgeries, implants, and drug deliveries is often encountered with several physical and biological issues such as poor retention at delivery sites, poor bio availability, longevity, limited water solubility, etc. [ 129 , 130 , 131 ]. To overcome these problems, PLA is coupled with various other biocompatible polymers for the fabrication of nano formulations used in medical therapeutic deliveries as approved by the FDA [ 132 , 133 , 134 ].…”

Section: Food and Drug Administration Approved Pla Formulations Used ...mentioning

confidence: 99%

Promising Role of Polylactic Acid as an Ingenious Biomaterial in Scaffolds, Drug Delivery, Tissue Engineering, and Medical Implants: Research Developments, and Prospective Applications

et al. 2023

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In the present scenario, the research is now being focused on the naturally occurring polymers that can gradually replace the existing synthetic polymers for the development of bio composites having applications in medical surgeries and human implants. With promising mechanical properties and bio compatibility with human tissues, poly lactic acid (PLA) is now being viewed as a future bio material. In order to examine the applicability of PLA in human implants, the current article sheds light on the synthesis of PLA and its various copolymers used to alter its physical and mechanical properties. In the latter half, various processes used for the fabrication of biomaterials are discussed in detail. Finally, biomaterials that are currently in use in the field of biomedical (Scaffolding, drug delivery, tissue engineering, medical implants, derma, cosmetics, medical surgeries, and human implants) are represented with respective advantages in the sphere of biomaterials.

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“…The essential oil from P. anisum has been triumphantly developed as a target preparation, and with advances in biological materials, the combination of PLA film materials, nano emulsions, and gel materials with oil has been affirmed as a new dosage form, which could greatly improve its antibacterial ability. In terms of antibacterial experiments, many studies demonstrated that oil and polysaccharide from P. anisum seeds and fruits exhibit antibacterial activity against a battery of gram-negative and gram-positive bacterium ( Table 8 ) [ 8 , 9 , 91 , 92 , 150 ]. Noteworthily, fire blight was a devastating disease of commercial crops of Rosaceae , ascribing to the highly infectious bacteria Erwiniaamylovora , and Akhlaghi et al found that P. anisum oil showed above-average antibiotic ability with a MIC of 31.25 μg/mL [ 93 ].…”

Section: Pharmacologymentioning

confidence: 99%

Emerging Biopharmaceuticals from Pimpinella Genus

Cao

Hassan

et al. 2023

Molecules

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Evolved over eons to encode biological assays, plants-derived natural products are still the first dawn of drugs. Most researchers have focused on natural compounds derived from commonly used Pimpinella species, such as P. anisum, P. thellungiana, P. saxifrage, and P. brachycarpa, to investigate their antioxidant, antibacterial, and anti-inflammatory properties. Ethnopharmacological studies demonstrated that the genus Pimpinella has the homology characteristics of medicine and food and mainly in the therapy of gastrointestinal dysfunction, respiratory diseases, deworming, and diuresis. The natural product investigation of Pimpinella spp. revealed numerous natural products containing phenylpropanoids, terpenoids, flavonoids, coumarins, sterols, and organic acids. These natural products have the potential to provide future drugs against crucial diseases, such as cancer, hypertension, microbial and insectile infections, and severe inflammations. It is an upcoming field of research to probe a novel and pharmaceutically clinical value on compounds from the genus Pimpinella. In this review, we attempt to summarize the present knowledge on the traditional applications, phytochemistry, and pharmacology of more than twenty-five species of the genus Pimpinella.

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Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections

Cited by 70 publications

References 47 publications

Trichoderma-Mediated ZnO Nanoparticles and Their Antibiofilm and Antibacterial Activities

Trichoderma-Mediated ZnO Nanoparticles and Their Antibiofilm and Antibacterial Activities

Promising Role of Polylactic Acid as an Ingenious Biomaterial in Scaffolds, Drug Delivery, Tissue Engineering, and Medical Implants: Research Developments, and Prospective Applications

Emerging Biopharmaceuticals from Pimpinella Genus

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