Membrane introduction Mass Spectrometry: Trends and applications

Johnson, Rudolph C.; Cooks, R. Graham; Allen, Todd M.; Cisper, M. E.; Hemberger, P. H.

doi:10.1002/(sici)1098-2787(2000)19:1<1::aid-mas1>3.0.co;2-y

Cited by 236 publications

(188 citation statements)

References 132 publications

(160 reference statements)

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“…For example, SCIEX triple quadrupoles were introduced in the 1980s to address this very problem, e.g., the Mississauga disaster was monitored in this way [17], although these successful systems were transportable, not portable [18,19]. Several versions of portable mass spectrometers have been used for in situ gasphase chemical analysis [20,21] based on selective membrane sampling [22][23][24][25]. A related sorbent introduction system using preconcentration in a solid matrix and thermal release was employed to achieve trace level detection of benzene with the handheld Mini 10.5 [26].…”

mentioning

confidence: 66%

Direct detection of benzene, toluene, and ethylbenzene at trace levels in ambient air by atmospheric pressure chemical ionization using a handheld mass spectrometer

Huang

Gao

Duncan

et al. 2010

J. Am. Soc. Mass Spectrom.

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The capabilities of a portable mass spectrometer for real-time monitoring of trace levels of benzene, toluene, and ethylbenzene in air are illustrated. An atmospheric pressure interface was built to implement atmospheric pressure chemical ionization for direct analysis of gas-phase samples on a previously described miniature mass spectrometer (Gao et al. Anal. Chem. 2006, 78, 5994 -6002). Linear dynamic ranges, limits of detection and other analytical figures of merit were evaluated: for benzene, a limit of detection of 0.2 parts-per-billion was achieved for air samples without any sample preconcentration. The corresponding limits of detection for toluene and ethylbenzene were 0.5 parts-per-billion and 0.7 parts-per-billion, respectively. These detection limits are well below the compounds' permissible exposure levels, even in the presence of added complex mixtures of organics at levels exceeding the parts-per-million level. The linear dynamic ranges of benzene, toluene, and ethylbenzene are limited to approximately two orders of magnitude by saturation of the detection electronics. (J Am Soc Mass Spectrom 2010, 21, 132-135)

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mentioning

confidence: 66%

Direct detection of benzene, toluene, and ethylbenzene at trace levels in ambient air by atmospheric pressure chemical ionization using a handheld mass spectrometer

Huang

Gao

Duncan

et al. 2010

J. Am. Soc. Mass Spectrom.

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“…The majority of MIMS experiments have employed polydimethylsiloxane (PDMS, or Silicone) membranes in both sheet and hollow fiber formats [2,3,9,10]. PDMS is hydrophobic, making it well suited for the sorptive extraction and measurement of hydrophobic volatile and semivolatile organic compounds (VOCs and SVOCs) [11].…”

mentioning

confidence: 99%

Condensed Phase Membrane Introduction Mass Spectrometry with Direct Electron Ionization: On-line Measurement of PAHs in Complex Aqueous Samples

Termopoli

Famiglini

Palma

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. Polycyclic aromatic hydrocarbons (PAHs) are USEPA regulated priority pollutants. Their low aqueous solubility requires very sensitive analytical methods for their detection, typically involving preconcentration steps. Presented is the first demonstrated 'proof of concept' use of condensed phase membrane introduction mass spectrometry (CP-MIMS) coupled with direct liquid electron ionization (DEI) for the direct, on-line measurement of PAHs in aqueous samples. DEI is very well suited for the ionization of PAHs and other nonpolar compounds, and is not significantly influenced by the co-elution of matrix components. Linear calibration data for low ppb levels of aqueous naphthalene, anthracene, and pyrene is demonstrated, with measured detection limits of 4 ppb. Analytical response times (t 10%-90% signal rise) ranged from 2.8 min for naphthalene to 4.7 min for pyrene. Both intra-and interday reproducibility has been assessed (<3% and 5% RSD, respectively). Direct measurements of ppb level PAHs spiked in a variety of real, complex environmental sample matrices is examined, including natural waters, sea waters, and a hydrocarbon extraction production waste water sample. For these spiked, complex samples, direct PAH measurement by CP-MIMS-DEI yielded minimal signal suppression from sample matrix effects (81%-104%). We demonstrate the use of this analytical approach to directly monitor real-time changes in aqueous PAH concentrations with potential applications for continuous on-line monitoring strategies and binding/adsorption studies in heterogeneous samples.

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“…Up until now, different kinds of miniature mass spectrometers have been developed, mainly using an ion trap as the mass analyzer, which is connected with different atmospheric pressure interfaces (APIs), including the membrane inlet (MI) [14][15][16][17], discontinuous atmospheric pressure interface (DAPI) [10,18,19], and continuous atmospheric pressure interface (CAPI) [20,21]. Among these APIs, MI was the first one to be adopted in MS systems.…”

Section: Introductionmentioning

confidence: 99%

Mini 2000: A Robust Miniature Mass Spectrometer with Continuous Atmospheric Pressure Interface

Meng

Zhang²,

Zhai

et al. 2018

Instruments

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Abstract:A miniature mass spectrometer with continuous atmospheric pressure interface (CAPI) developed previously in our lab has proved to have high stability and rapid analysis speed. With the aim of achieving smaller size, better performance and easier maintenance, in this study, an upgraded miniature mass spectrometer with CAPI was developed, in which all components were optimized and redesigned into a packaged unit. Using a more powerful pumping system, better analytical performances were obtained for this system. The miniature mass spectrometer has the capability to perform tandem mass spectrometry, and could be coupled with ambient ionization sources for analysis of different samples. Good stability (signal relative standard deviation, RSD < 5%), high sensitivity (limit of detection, LOD 10 ng/mL), better than unit mass resolution, and a broad mass range (from 150 Da to 2000 Da) were obtained. Integrated with a tablet computer for system control, the miniature mass spectrometer has dimensions of 38 cm × 23 cm × 34 cm (length × width × height), and is 13 kg in total weight. The whole system is powered by an adapter with a power consumption of 200 watts in total.

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Membrane introduction Mass Spectrometry: Trends and applications

Cited by 236 publications

References 132 publications

Direct detection of benzene, toluene, and ethylbenzene at trace levels in ambient air by atmospheric pressure chemical ionization using a handheld mass spectrometer

Direct detection of benzene, toluene, and ethylbenzene at trace levels in ambient air by atmospheric pressure chemical ionization using a handheld mass spectrometer

Condensed Phase Membrane Introduction Mass Spectrometry with Direct Electron Ionization: On-line Measurement of PAHs in Complex Aqueous Samples

Mini 2000: A Robust Miniature Mass Spectrometer with Continuous Atmospheric Pressure Interface

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