Mini 2000: A Robust Miniature Mass Spectrometer with Continuous Atmospheric Pressure Interface

Abstract

Abstract:A miniature mass spectrometer with continuous atmospheric pressure interface (CAPI) developed previously in our lab has proved to have high stability and rapid analysis speed. With the aim of achieving smaller size, better performance and easier maintenance, in this study, an upgraded miniature mass spectrometer with CAPI was developed, in which all components were optimized and redesigned into a packaged unit. Using a more powerful pumping system, better analytical performances were obtained for this system. The miniature mass spectrometer has the capability to perform tandem mass spectrometry, and could be coupled with ambient ionization sources for analysis of different samples. Good stability (signal relative standard deviation, RSD < 5%), high sensitivity (limit of detection, LOD 10 ng/mL), better than unit mass resolution, and a broad mass range (from 150 Da to 2000 Da) were obtained. Integrated with a tablet computer for system control, the miniature mass spectrometer has dimensions of 38 cm × 23 cm × 34 cm (length × width × height), and is 13 kg in total weight. The whole system is powered by an adapter with a power consumption of 200 watts in total.

Electric modeling and characterization of pulsed high‐voltage nanoelectrospray ionization sources by a miniature ion trap mass spectrometer

“…The pulsed HV nano‐ESI was coupled to a miniature mass spectrometer (Mini 2000) developed in our lab, whose details have been reported in previous publications . In brief, Mini 2000 is a continuous atmospheric pressure interfaced miniature mass spectrometer with a two‐stage vacuum chamber, in which an ion funnel placed in the first vacuum chamber and an ion trap as the mass analyzer in the second one.…”

The blind men and the elephant: challenges in the analysis of complex natural mixtures

“…It was considered that passive sampling over many days would generate a more comprehensive specimen from a heterogeneous environment, as well as the ability to take miniaturised analytical equipment into the eld for on-site point and shoot analyses. [30][31][32] The second was that there was in general a lack of gures of merit presented. With the exception of a few posters presented by early career researchers, no one discussed the precision in the amount of material measured, nor the accuracy of these levels.…”

Portable Multiplex Optical Assays

“…Reprinted from refs. (a), (b), (c), (d), (e,f), and (g,h) with permission: Copyright 2006 and 2014, American Chemical Society (a,d,i); ACS AuthorChoice License open access publication (b,c); CC‐BY 4.0 open access publications (e,f); Elsevier user license open access publication (g,h).…”

“…An alternative mass spectrometry approach is to use atmospheric pressure. Using this method, A Mini 2000 platform was developed and integrated with a handheld tablet computer (Figure E) . This miniaturized mass analyzer measured caffeine and other polyethylene glycol (PEG) 600–1500 chemicals at specific alternating current injection frequencies up to 10 ng mL −1 sensitivity (Figure F).…”