Melting Point and Molecular Symmetry

Brown, R. J. C.; Brown, R. F. C.

doi:10.1021/ed077p724

Cited by 160 publications

(131 citation statements)

References 17 publications

(27 reference statements)

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“…From those, conglomerates have always higher melting point from their enantiomeric analogues (Carnelley's law), especially with higher molecular symmetry, while the freezing point varies according to the racemic solution and its crystallization type. Thus, special research interest is focused primarily at the in vitro study of the crystallization type of the solutions of racemic mixtures from natural cancer proteins from various malignant neoplasms with their synthetic enantiomers, regarding the increase of their freezing point and their crystallization at higher temperature from that required for the crystallization of natural cancer protein solutions [2][3][4][5][6][7][8].…”

Section: Methodmentioning

confidence: 99%

Pilot Therapeutic Protocol for the Treatment of Local Advanced Disease, such as the Generalized Peritoneal Carcinomatosis and for the Treatment of Distant Metastases in Human Malignant Neoplastic Disease-Targeting the Medium

Bouras¹

2017

J Gastrointest Cancer Stromal Tumor

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The phenomenon of life and the open thermodynamic systems in general may be described from the existence of (i) a distinct separating border from the surrounding environment (ii) specific structures inside it, which are functioning with some form of energy exchange with the environment and (iii) the medium inside wherewith these functions are taking place. For living cells, this distinct border is the cell membrane, the structures are the cellular organelles and the medium is the cytoplasm (which is mainly consists of water). The research idea of this therapeutic protocol aims at the selective destruction of the "medium", namely the cytoplasm of the cancer cell, with concurrently preservation of the integrity of the cytoplasm of the nearby normal cells/tissues. This may be achieved with the gradual lowering of the core body temperature of the patient and concurrently introducing of a therapeutic solution of complementary, "anti-sense", polypeptides in the cancer cell, individually synthesized for every patient, accordingly to his malignancy type, with theoretically increasing of the freezing point of the malignant cell's cytoplasm, subsequent crystallization, expansion and rupture of its membrane at a temperature where the cytoplasm of the nearby healthy cells/tissues will remain intact.

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Section: Methodmentioning

confidence: 99%

Pilot Therapeutic Protocol for the Treatment of Local Advanced Disease, such as the Generalized Peritoneal Carcinomatosis and for the Treatment of Distant Metastases in Human Malignant Neoplastic Disease-Targeting the Medium

Bouras¹

2017

J Gastrointest Cancer Stromal Tumor

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“…In the case of 5, melting processes are preceded by decomposition. As a general rule, melting points do generally increase with the increasing molecular mass and symmetrical molecules in the crystalline form have higher melting points compared with those of similar structure but with a lower symmetry [8][9][10][11]. The structures of the studied compounds are composed of 3-(2-furanyl)-8-aryl-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4 (6H)-one unit and differently substituted benzene fragments.…”

Section: Comparison Of the Thermal Behaviour Of 1-6 In Airmentioning

confidence: 95%

“…This derogation from the general rule can be associated with the structure of these compounds. In the case of compound 5, it is more likely that the electronegative Cl atoms can be engaged in polar interactions like p-p or H-bonding which can increase the melting point [8][9][10].…”

Section: Comparison Of the Thermal Behaviour Of 1-6 In Airmentioning

confidence: 99%

Thermal behaviour of antiproliferative active 3-(2-furanyl)-8-aryl-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-ones

Bartyzel

Sztanke

2017

J Therm Anal Calorim

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Thermal analysis is commonly used in the pharmaceutical field because it is an important tool in the solution of problems involving development, production and quality control of medicines. This paper presents the thermal behaviour of six anticancer active derivativestriazin-4(6H)-one. The samples were characterized by the TG-DSC and TG-FTIR analyses. The studied compounds are stable at room temperature which is important for medical application. The TG analysis under dynamic air atmosphere revealed that thermal degradation of the compounds starts above 300°C and proceeds in two steps. The melting processes of compounds are observed before starting their decomposition or at the beginning of their combustion. Pyrolysis processes under nitrogen atmosphere take place in single or two steps. The major pyrolysis gaseous products identified are ammonia, carbon dioxide, isocyanic acid and its derivatives, hydrogen cyanide, aniline or its derivatives and carbon monoxide.

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“…À49.3 8C for 2b and À54.2 8C for 2c). It has been reported that the T m of an organic compound is determined by the strength of its crystal lattice, which is in turn controlled by three main factors: intermolecular forces, molecular symmetry and degree of conformational freedom of the molecule [20,21].…”

Section: Melting Pointmentioning

confidence: 99%

N,N-dialkyl perfluoroalkanesulfonamides: Synthesis, characterization and properties

Liao

Nie

et al. 2013

Journal of Fluorine Chemistry

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Melting Point and Molecular Symmetry

Cited by 160 publications

References 17 publications

Pilot Therapeutic Protocol for the Treatment of Local Advanced Disease, such as the Generalized Peritoneal Carcinomatosis and for the Treatment of Distant Metastases in Human Malignant Neoplastic Disease-Targeting the Medium

Pilot Therapeutic Protocol for the Treatment of Local Advanced Disease, such as the Generalized Peritoneal Carcinomatosis and for the Treatment of Distant Metastases in Human Malignant Neoplastic Disease-Targeting the Medium

Thermal behaviour of antiproliferative active 3-(2-furanyl)-8-aryl-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-ones

N,N-dialkyl perfluoroalkanesulfonamides: Synthesis, characterization and properties

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