Chylous peritonitis is the acute accumulation of intestinal lymph (chyle) in the peritoneal cavity that presents with symptoms and signs of acute abdomen. Generally idiopathic, it represents a rare cause of acute surgical abdomen. The diagnosis is usually made at laparotomy, since there are no distinctive features to suspect this entity preoperatively.We describe the case of a 46-year-old man who pre-sented with typical symptoms of acute appendicitis and underwent emergency laparotomy for acute abdomen . No obvious lesions from the chylous ap-paratus or from the alimentary tract were detected at laparotomy. The postoperative period was un-complicated and no underlying disease was found at extensive postoperative investigation.
The complex signaling pathways and interactions inside and among cells which are responsible for the appearance and evolving of malignancy have a distinct and well separated border, the translation process, where the signals of a mutant and dysregulating genome are becoming specific proteins evolving to the malignant phenotype. We selected as translation target the Fragile X -Mental Retardation Protein (FMRP) of the breast cancer cell, a protein of whose role in translation has not clearly elucidated yet. Triple negative breast cancer cell lines (BCCL)-(BT20, MDA-MB-231, Hs578 T) were transfected by plasmid with mutant FMRP at progressively increased CGG triplets (from 45 to 200 repeats at a one by one CGG repeat step up process) and the production of the mutant protein was verified with the SUNSET method and Western blot analysis. Afterwards, the impact in proteinosynthesis inhibition and apoptosis induction of the transfected BCCL in relation to normal epithelial breast cell lines (NEBCL) was evaluated. Preliminary in vitro results showed slower rates of proteinosynthesis and higher apoptotic rate of the 78 CGG & 84 CGG repeat mutant FMRP transfected BCCL in compared to NEBCL, while for all other transfected BCCL no statistically significant differentiation was found.
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