N,N-dialkyl perfluoroalkanesulfonamides: Synthesis, characterization and properties

Fu, Shitao; Liao, Shuai-Ling; Nie, Jun; Zhou, Zhibin

doi:10.1016/j.jfluchem.2013.01.009

Cited by 25 publications

(11 citation statements)

References 36 publications

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“…The SuFEx reactions typically use common sulfonylation conditions (Et 3 N, CH 2 Cl 2 ); [130,[136][137][138][139] also, ammonia [140][141][142][143][144][145] or aliphatic amines [146][147][148][149][150][151] can act both as reagents and as bases (Scheme 15A). One more important modification includes reaction of sulfonyl halides and aliphatic N-silylamines in refluxing in MeCN.…”

Section: Applications In Synthetic and Medicinal Chemistrymentioning

confidence: 99%

Emerging Building Blocks for Medicinal Chemistry: Recent Synthetic Advances

2021

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Current medicinal chemistry relies heavily on the quality of building blocks, i. e. reagents used to introduce chemical diversity into the target molecules. The last decade witnessed an emergence of many novel (or well-overlooked old) chemotypes for drug discovery, which is related to adapting new synthetic methodologies, designing new sp 3 -enriched bioisosteres, paying attention to previously underrated (or even unwanted) structural motifs, or combination thereof. In this review with 532 references, a survey of selected chemotypes that emerged recently in medicinal chemistry is provided, with a focus on the synthesis of the corresponding building blocks. Thus, saturated (hetero)aliphatic boronates, sulfonyl fluorides, sulfinates, non-classical sp 3 -enriched benzene isosteres, bicyclic morpholine/piperidine/piperazine analogs, as well as gemdifluorinated cycloalkanes (as an example of emerging fluorinated motifs) are discussed.

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Section: Applications In Synthetic and Medicinal Chemistrymentioning

confidence: 99%

Emerging Building Blocks for Medicinal Chemistry: Recent Synthetic Advances

2021

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“…In addition, Zakerhamidi et al 192 determined E T (30) values for nematic liquid crystals. Fu et al 193 prepared a series of room-temperature liquid N,N-dialkylperfluoroalkane sulfonamides, the E T (30) values of which are between 45.4 and 55.2 kcal mol −1 , comparable with that of short-chain alcohols. Luo et al 194 proposed the use of 3-methyl-1,2-BN-cyclopentane as a hydrogen-storage material and determined its E T (30) value as 54.9 kcal mol −1 .…”

Section: X-ray Crystallographic Studies Of the Molecular Structures O...mentioning

confidence: 99%

PyridiniumN-Phenolate Betaine Dyes

2014

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Introduction 10429 2. Historical Contextualization 10431 3. Synthesis of Pyridinium N-Phenolate Dyes 10433 4. Solvatochromic Properties of Pyridinium N-Phenolate Dyes 10435 4.1. X-ray Crystallographic Studies of the Molecular Structures of Pyridinium N-Phenolate Dyes 10437 4.2. Quantum Chemical Calculations Involving Pyridinium N-Phenolate Dyes 10438 4.3. The E T (30) and E T N Solvent Polarity Scale 10440 4.4. Multiparametric Approaches to the Analysis of the E T (30) and E T N Scale 10441 5. Secondary Solvatochromic Pyridinium N-Phenolate Dyes 10442 6. Investigation of the Physical Properties of Room-Temperature Ionic Liquids 10443 7. Thermosolvatochromism of Pyridinium N-Phenolate Dyes 10450 8. Halochromism of Pyridinium N-Phenolate Dyes 10451 9. Piezosolvatochromism of Pyridinium N-Phenolate Dyes 10452 10. Pyridinium N-Phenolate Dyes in the Investigation of Solvent Mixtures 10453 11. Application of Pyridinium N-Phenolate Dyes in the Construction of Chromogenic Chemosensors 10455 11.1. Chirosolvatochromism of Pyridinium N-Phenolate Dyes 10456 11.2. Chromoionophores 10456 11.3. Chromogenic Chemosensors for Anionic Species 10457 11.4. Chromogenic Chemosensors for Neutral Analytes 10458 12. Pyridinium N-Phenolate Dyes as Probes To Measure the Polarity of Solid Surfaces 10459 13. Pyridinium N-Phenolate Dyes in the Study of Microheterogeneous Systems 10460 13.1. Investigation of Surfactants in Aqueous and Organic Media 10462 13.2. Pyridinium N-Phenolate Dyes in the Investigation of Cyclodextrins in Solution 10463 13.

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“…10d). 186 Alternatively, the reaction between the Grignard reagent and sulfonic anhydride also provides a practical route to prepare fluorinated sulfones in a decent yield. As depicted in Fig.…”

Section: Functional Modification Of Fluorinated Moleculesmentioning

confidence: 99%