Meloxicam in the treatment of in vitro and in vivo models of urinary bladder cancer

Ruthenium porphyrin-induced photodamage in bladder cancer cells

“…Preclinical studies also play an important role in this aspect [32]. Investigations on bladdercancer cell lines is a natural first step to determine the properties of newly developed drugs and to test various treatment strategies [6,[33][34][35][36].…”

Bladder cancer prevention

“…Experiments on mice with bladder cancer induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BNN) demonstrated that rofecoxib (a selective COX-2 inhibitor) caused a considerable decrease in the incidence of precancerous lesions and tumors [62]. The effects for meloxicam were not statistically significant [63]. The anticarcinogenic properties of meloxicam, however, were further tested on three human cell lines of bladder cancer and shown to significantly increase DNA damage in cancer cells and inhibit their proliferation [63].…”

“…The effects for meloxicam were not statistically significant [63]. The anticarcinogenic properties of meloxicam, however, were further tested on three human cell lines of bladder cancer and shown to significantly increase DNA damage in cancer cells and inhibit their proliferation [63]. The proapoptotic role of celecoxib is associated with its ability to induce the autophagy of cancer cells [64].…”

Improved Anticancer Activity of Meloxicam Hydrogels in K562 and HL60 Cell Lines

“…Various formulations of meloxicam were available for potential anticancer applications. [8][9][10][11] Currently, in situ gel forming formulations as a novel idea of drug delivery to patients as a liquid dosage form, yet achieve sustained release of drug for the desired period. 12 Different delivery systems based on polymers have been developed, which are able to increase the residence time of the formulation at absorption site of drugs.…”