Improved Anticancer Activity of Meloxicam Hydrogels in K562 and HL60 Cell Lines

Thimmaraju, Manish Kumar; Bheemanapally, Khaggeswar; Dharavath, Rajkumar; Kakarla, Lavanya; Botlagunta, Mahendran

doi:10.5530/jyp.2017.9.41

Cited by 5 publications

(3 citation statements)

References 15 publications

(16 reference statements)

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“…The concentration of MT in hydrogel was determined using developed validated analytical method 10 . Accurately weighted 10 mg standard metronidazole was dissolved in 65.0 ml of methanol and made up to 100 ml with Millipore water to obtain the final concentration of 100 µg/mL.…”

Section: Hplc Analytical Methodmentioning

confidence: 99%

Untitled

2019

IJPSR

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The present research work was planned to formulate poloxamer 407 based hydrogel formulations of metronidazole and the evaluation of various parameters like swelling behavior, drug PH stability, in-vitro and in-vivo drug release, and in-vitro cytotoxic activity. Two different concentrations of metronidazole hydrogel formulations were prepared using poloxamer 407 and were assessed by a validated HPLC method for drug content, pH stability, and in-vivo drug release. Further, in-vitro anticancer activity was evaluated using sulphorhodamine B (SRB) assay in SCC29 cell lines. Both the formulations F1 and f2 showed better pH stability at pH 3.5, 5.5 and 6.8. The formulation F1 was able to absorb about 152% of its weight of water within 80 min, whereas F2 absorbed 167.4% of its weight of water and remains constant over 100 min. In-vitro and in-vivo drug release pattern showed half-life at 6 h, AUC 0−t 692 and 684ng h/ml, C max 1059 and 1142 ng/ml for F1 and F2 respectively. Hydrogel formulation F1 showed improved percentage control growth when compared to F2 hydrogel formulation and metronidazole alone.

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Section: Hplc Analytical Methodmentioning

confidence: 99%

Untitled

2019

IJPSR

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“…To date, PF127 injectable hydrogels (Table 2) have been proposed as delivery vehicles for drug and drug crystals in the treatment of both blood and solid tumors [58,59]. Interestingly, such systems were found to reverse the multi-drug resistance in MCF-7/ADR cells because of the ability to increase the intracellular drug concentration escaping the efflux pumps on the cell membrane [59].…”

Section: Synthetic Injectable Hydrogelsmentioning

confidence: 99%

Injectable Hydrogels for Cancer Therapy over the Last Decade

et al. 2019

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The interest in injectable hydrogels for cancer treatment has been significantly growing over the last decade, due to the availability of a wide range of starting polymer structures with tailored features and high chemical versatility. Many research groups are working on the development of highly engineered injectable delivery vehicle systems suitable for combined chemo-and radio-therapy, as well as thermal and photo-thermal ablation, with the aim of finding out effective solutions to overcome the current obstacles of conventional therapeutic protocols. Within this work, we have reviewed and discussed the most recent injectable hydrogel systems, focusing on the structure and properties of the starting polymers, which are mainly classified into natural or synthetic sources. Moreover, mapping the research landscape of the fabrication strategies, the main outcome of each system is discussed in light of possible clinical applications.

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“…Therefore, our findings demonstrate that developed NPs formulation could be used to improve the efficacy of chemotherapy by exerting chemo-preventive effects against induced carcinogenesis at lower doses. Thimmaraju et al (2017) demonstrated poloxamer based formulations of meloxicam. They evaluated various parameters like pH stability, drug release and in vitro anti-cancer activities in cell lines with an intention to formulate injectable sustained biodegradable drug delivery system.…”

Section: Nano-formulations For Cancer Therapymentioning

confidence: 99%

Nano-Pharmaceuticals in Medicine

Gupta

Dinda²

2018

Proceedings of the Indian National Science Academy

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Nanotechnology is an emerging field with a major goal to target drug delivery to improve the efficacy and safety profile. The application of nanotechnology to medicine, known as nano-medicine, concerns the use of precisely engineered materials to develop novel therapeutic and diagnostic modalities. Nanomaterials possess various unique physiochemical properties, such as small size, large surface area to mass ratio, and high reactivity, which are different from bulk materials. These properties can be used to overcome limitations found associated with traditional therapeutic and diagnostic agents. This review focuses on recent progress and development in the field nano-pharmaceuticals for various biomedical applications.

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Improved Anticancer Activity of Meloxicam Hydrogels in K562 and HL60 Cell Lines

Cited by 5 publications

References 15 publications

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Injectable Hydrogels for Cancer Therapy over the Last Decade

Nano-Pharmaceuticals in Medicine

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