Injectable Hydrogels for Cancer Therapy over the Last Decade

Cirillo, Giuseppe; Spizzirri, Umile Gianfranco; Curcio, Manuela; Nicoletta, Fiore Pasquale; Iemma, Francesca

doi:10.3390/pharmaceutics11090486

Cited by 74 publications

(59 citation statements)

References 302 publications

(347 reference statements)

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“…In order to be applied in clinical trials, injectable hydrogels must have several essential properties, such as biocompatibility, biodegradability and non-toxicity, must be stable, and must have superior mechanical and viscoelastic properties, in order to be able to withstand possible deformations that appear in the body. Regarding the viscosity, it is important that the precursor aqueous solutions have adequate shear-thinning properties that allow them to be easily injected [39]. An essential factor of injectable hydrogels is their biodegradability so that, after degradation, the products obtained are eliminated from the body, without surgery to remove them [146].…”

Section: Injectable Cellulose-based Hydrogels In Drug Deliverymentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

121

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Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.

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Section: Injectable Cellulose-based Hydrogels In Drug Deliverymentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

121

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“…Nevertheless, the potential toxic agents, such as cross‐linking monomers, photo‐initiators, organic solvents, or catalysts that might be employed for the formation of this type of hydrogel, can limit their in vivo applications. [ 30 ] Different methods are reported in the literature for chemical cross‐linking. [ 31 ] These methods lead to the formation of hydrogels with high mechanical properties, which can be utilized to prepare the IHs with long‐lasting features.…”

Section: Preparation Methods Of Ihsmentioning

confidence: 99%

Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

Poustchi

Amani

Ahmadian³

et al. 2020

Adv Healthcare Materials

108

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The complexity of hard-to-treat diseases strongly undermines the therapeutic potential of available treatment options. Therefore, a paradigm shift from monotherapy toward combination therapy has been observed in clinical research to improve the efficiency of available treatment options. The advantages of combination therapy include the possibility of synchronous alteration of different biological pathways, reducing the required effective therapeutic dose, reducing drug resistance, and lowering the overall costs of treatment. The tunable physical properties, excellent biocompatibility, facile preparation, and ease of administration with minimal invasiveness of injectable hydrogels (IHs) have made them excellent candidates to solve the clinical and pharmacological limitations of present systems for multitherapy by direct delivery of therapeutic payloads and improving therapeutic responses through the formation of depots containing drugs, genes, cells, or a combination of them in the body after a single injection. In this review, currently available methods for the design and fabrication of IHs are systematically discussed in the first section. Next, as a step toward establishing IHs for future multimodal synergistic therapies, recent advances in cancer combination therapy, wound healing, and tissue engineering are addressed in detail in the following sections. Finally, opportunities and challenges associated with IHs for multitherapy are listed and further discussed.

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“…Copyright 2017 Elsevier; silk and polyvinyl alcohol (PVA) were adapted with permission from [130]. Copyright 2017 Elsevier; polycaprolactone (PCL) and polylactic acid (PLA) [131]; agarose and gelatin [132]; collagen [133]. pluronic were adapted with permission from [129].…”

Section: Polylactic Acid and Poly Lactic-co-glycolic Acidmentioning

confidence: 99%

Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering

Park

Kim

et al. 2020

Polymers

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Three-dimensional (3D) bioprinting technology has emerged as a powerful biofabrication platform for tissue engineering because of its ability to engineer living cells and biomaterial-based 3D objects. Over the last few decades, droplet-based, extrusion-based, and laser-assisted bioprinters have been developed to fulfill certain requirements in terms of resolution, cell viability, cell density, etc. Simultaneously, various bio-inks based on natural–synthetic biomaterials have been developed and applied for successful tissue regeneration. To engineer more realistic artificial tissues/organs, mixtures of bio-inks with various recipes have also been developed. Taken together, this review describes the fundamental characteristics of the existing bioprinters and bio-inks that have been currently developed, followed by their advantages and disadvantages. Finally, various tissue engineering applications using 3D bioprinting are briefly introduced.

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Injectable Hydrogels for Cancer Therapy over the Last Decade

Cited by 74 publications

References 302 publications

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering

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