Nano-Pharmaceuticals in Medicine

Gupta, Yashwant; Dinda, Amit Kumar

doi:10.16943/ptinsa/2018/49308

Cited by 1 publication

(1 citation statement)

References 21 publications

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“…There are various modes of action utilized by these nanoparticles to target cells or tissues specifically. One of the mechanisms is through binding to certain cell surface receptors that may be overexpressed on the anticipated target cells/tissues [ 116 ]. These drug delivery systems can also diffuse into cells or tissues through passive permeability.…”

Section: Nanoparticlesmentioning

confidence: 99%

Nanoparticles Formulations of Artemisinin and Derivatives as Potential Therapeutics for the Treatment of Cancer, Leishmaniasis and Malaria

Alven

Aderibigbe

2020

Pharmaceutics

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Cancer, malaria, and leishmaniasis remain the deadly diseases around the world although several strategies of treatment have been developed. However, most of the drugs used to treat the aforementioned diseases suffer from several pharmacological limitations such as poor pharmacokinetics, toxicity, drug resistance, poor bioavailability and water solubility. Artemisinin and its derivatives are antimalarial drugs. However, they also exhibit anticancer and antileishmanial activity. They have been evaluated as potential anticancer and antileishmanial drugs but their use is also limited by their poor water solubility and poor bioavailability. To overcome the aforementioned limitations associated with artemisinin and its derivatives used for the treatment of these diseases, they have been incorporated into nanoparticles. Several researchers incorporated this class of drugs into nanoparticles resulting in enhanced therapeutic outcomes. Their potential efficacy for the treatment of parasitic infections such as malaria and leishmaniasis and chronic diseases such as cancer has been reported. This review article will be focused on the nanoparticles formulations of artemisinin and derivatives for the treatment of cancer, malaria, and leishmaniasis and the biological outcomes (in vitro and in vivo).

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Section: Nanoparticlesmentioning

confidence: 99%