Ruthenium porphyrin-induced photodamage in bladder cancer cells

Bogoeva, Vanya; Siksjø, Monica; Sæterbø, Kristin G.; Melø, Thor Bernt; Bjørkøy, Astrid; Lindgren, Mikael; Gederaas, Odrun Arna

doi:10.1016/j.pdpdt.2016.01.012

Cited by 36 publications

(25 citation statements)

References 45 publications

(59 reference statements)

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“…Despite the generation of singlet oxygen the compound does not have good spectral properties to act as photosensitizer. Nevertheless, RuP has lower IC 50 compared with cisplatin [136] (Fig. 21).…”

Section: Porphyrin Related Psmentioning

confidence: 97%

Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity

León

Cadavid-Vargas²,

Virgilio³

et al. 2017

CMC

120

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Cancer is a group of diseases involving abnormal cell growth. The cells grow uncontrollably with the potential to invade and spread to other parts of the body. This disease is one of the principal death causes in the world, thus becoming a significant topic of scientific research. On the other hand, transition metals play a fundamental role in different living systems. In particular, Metallodrugs represent new and powerful tools for diverse therapeutic applications. To date, various metallodrugs display interesting biological activities for chemotherapy. In this field, cisplatin was the first inorganic compound with high relevance in cancer treatment. This compound was a leader agent in clinical use. Toxicity and resistance problems trigger the development of other platinum drugs with better clinical perspective and also raise the scientific interest for the putative antitumor properties of V, Ru and Cu compounds. Several scientific articles show that complexes of these metals are the new metal-based drugs used in the treatment of several cancers, such us, lung, colon, breast, bladder, etc. In this review we recapitulate current information and new advances on antitumor in vitro effects of several organic and inorganic compounds derived from copper, ruthenium and vanadium. These metal derived compounds targeting DNA or cell proteins involved in cell signaling pathways related to cancer. The mechanisms of cell death of these metallodrugs have also been comprehensibly reviewed. The knowledge of these mechanisms of death and the relationship between chemical structure and biological activity may be useful for the design of new metal-based drugs with promising pharmacologic applications as anticancer agents.

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Section: Porphyrin Related Psmentioning

confidence: 97%

Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity

León

Cadavid-Vargas²,

Virgilio³

et al. 2017

CMC

120

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“…The triplet state of RuP generates singlet oxygen upon blue/green light excitation, which limits the use of these porphyrins to PDT of small tumors. Blue light irradiation of RuP in rat bladder cancer cells AY27 resulted in light-dependent cell death mainly via necrosis [64]. Some ruthenium metalloporphyrins were tested as oxidative DNA chain cleavers [65].…”

Section: Metallotetrapyrroles -The Influence Of Coordinated Metals Onmentioning

confidence: 99%

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Dąbrowski

Pucelik

Regiel-Futyra

et al. 2016

Coordination Chemistry Reviews

235

189

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“…Complex 2f with meso -tetrakis(pentafluorophenyl)porphyrin ligand displays the lowest cellular uptake and lipophilicity among the bis-NHC complexes. Cationic iridium porphyrin complexes show more efficient cellular internalization and hence increase in anticancer activity as indicated by lower IC 50 values compared to those of the neutral complex [Ir III (oep)Cl(CO)] and the isoelectronic [Ru II (oep)(CO)] reported by Bogoeva and co-workers 40. Complex 2c accumulates preferentially in cellular ER and somewhat in mitochondria as shown by the confocal laser microscopy images in the co-staining experiments, which could account for the subsequent induction of ER stress and mitochondrial membrane depolarization by this complex.…”

Section: Discussionmentioning

confidence: 98%

Luminescent ruffled iridium(iii) porphyrin complexes containing N-heterocyclic carbene ligands: structures, spectroscopies and potent antitumor activities under dark and light irradiation conditions

et al. 2019

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Ruthenium porphyrin-induced photodamage in bladder cancer cells

Cited by 36 publications

References 45 publications

Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity

Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Luminescent ruffled iridium(iii) porphyrin complexes containing N-heterocyclic carbene ligands: structures, spectroscopies and potent antitumor activities under dark and light irradiation conditions

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