Luminescent ruffled iridium(iii) porphyrin complexes containing N-heterocyclic carbene ligands: structures, spectroscopies and potent antitumor activities under dark and light irradiation conditions

Abstract

Luminescent iridium(iii) porphyrin NHC complexes are efficient singlet oxygen generators and antitumor agents.

A Rhenium Isonitrile Complex Induces Unfolded Protein Response‐Mediated Apoptosis in Cancer Cells

“…Although we have investigated potential causes of eIF2α phosphorylation, including proteasome inhibition, HSP90 inhibition, and reactive oxygen species generation, we found no evidence that TRIP triggers protein misfolding through these pathways (Figures S43–S47, Supporting Information). Recently, a range of diverse metal complexes have been shown to induce ER stress . The major mechanism of action proposed for these agents is through the production of reactive oxygen species (ROS).…”

“…Recently,arange of diverse metal complexes have been shown to induce ER stress. [7][8][9][10][11][38][39][40][41][42][43][44][45][46][47] Them ajor mechanism of action proposedf or these agents is through the production of reactiveo xygen species( ROS). Only af ew studies have discoveredm etal complexes that induce ER stress in the absence of ROS generation.…”

Iridium(III)‐Catalyzed Intermolecular C(sp3)−H Insertion Reaction of Quinoid Carbene: A Radical Mechanism

“…[10] Ag reat challenge still lies in the development of intermolecular reactions.T he closed-shell Ru-QC complexes could undergo intermolecular HATwith aliphatic C À Hs ubstrates,y et no subsequent radical rebound process was observed, presumably because of the reductive quenching of the ligand radical by the electron-rich Ru II center (Figure 1b). [4] We envisioned that changing the metal center to aless reducing Ir III [11] might increase the lifetime of the ligand radical and thus facilitate the rebound step.H erein is described ap rotocol of Ir III /porphyrin-catalyzed intermolecular QC insertion reactions into C(sp 3 ) À Hbonds by aradical mechanism.…”

Molecular Systems Combining Porphyrinoids and N‐Heterocyclic Carbenes

“…Che, Lok and co-workers recently reported the synthesis of a panel of mono-and bis(NHC) iridium(III) porphyrin complexes. [23] These compounds were prepared by reacting bis (NHC) silver(I) complex with [Ir III (porphyrin)(CO)Cl] via transmetalation reactions as illustrated in Scheme 3. Mono-and bis (NHC) iridium(III) complexes were obtained in 60-74 % and 70-96 % yields, respectively.…”