Melioidosis: Recrudescence Associated with Bronchogenic Carcinoma Twenty-six Years following Initial Geographic Exposure

Mays, Edward E.; Ricketts, Edward A.

doi:10.1378/chest.68.2.261

Cited by 146 publications

(77 citation statements)

References 9 publications

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“…5,19 However, our recurrence rate after cotrimoxazole monotherapy is comparable to that reported from Australia where twice a dosage of cotrimoxazole is used. 5 There are limitations to our study.…”

Section: Discussionsupporting

confidence: 81%

Outcomes of Patients with Melioidosis Treated with Cotrimoxazole Alone for Eradication Therapy

Chusri¹,

Hortiwakul²,

Charoenmak³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. We retrospectively reviewed a 10-year experience of administration of cotrimoxazole alone in 31 patients compared with 109 patients who received conventional eradication therapy (cotrimoxazole plus doxycycline). The baseline characteristics, the clinical manifestations, the initial intravenous antibiotic treatments, and the mean duration of eradication therapy between the two groups were similar. The culture-confirmed recurrences among the patients who received cotrimoxazole alone and those who received the conventional regimen were not significantly different

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Section: Discussionsupporting

confidence: 81%

Outcomes of Patients with Melioidosis Treated with Cotrimoxazole Alone for Eradication Therapy

Chusri¹,

Hortiwakul²,

Charoenmak³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…Of equal concern, there is evidence that the bacterium does not cause overt disease in all individuals exposed to the bacterium but is able to persist at unknown sites in the body to become reactivated later in life. Possibly the best documented examples of this are in Vietnam veterans who developed disease, in one case 26 years later, after returning to the U.S. (7)(8)(9).…”

Section: Elioidosis Is a Bacterial Infection Caused By Burkholderiamentioning

confidence: 99%

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

Holden

Titball

Peacock

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

683

690

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Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world and accounts for 20% of community-acquired septicaemias in northeastern Thailand where half of those affected die. Here we report the complete genome of B. pseudomallei, which is composed of two chromosomes of 4.07 megabase pairs and 3.17 megabase pairs, showing significant functional partitioning of genes between them. The large chromosome encodes many of the core functions associated with central metabolism and cell growth, whereas the small chromosome carries more accessory functions associated with adaptation and survival in different niches. Genomic comparisons with closely and more distantly related bacteria revealed a greater level of gene order conservation and a greater number of orthologous genes on the large chromosome, suggesting that the two replicons have distinct evolutionary origins. A striking feature of the genome was the presence of 16 genomic islands (GIs) that together made up 6.1% of the genome. Further analysis revealed these islands to be variably present in a collection of invasive and soil isolates but entirely absent from the clonally related organism B. mallei. We propose that variable horizontal gene acquisition by B. pseudomallei is an important feature of recent genetic evolution and that this has resulted in a genetically diverse pathogenic species.

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“…Symptoms of infection vary greatly but can generally be described as being acute, subacute, or chronic (5). The bacterium is reportedly able to persist in a host for decades prior to reactivation (26). The mechanism by which the organism is able to persist in the host is unknown.…”

mentioning

confidence: 99%

Development of Signature-Tagged Mutagenesis in Burkholderia pseudomallei To Identify Genes Important in Survival and Pathogenesis

et al. 2007

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Burkholderia pseudomallei, the causative agent of melioidosis, is an important human pathogen in Southeast Asia and northern Australia for which a vaccine is unavailable. A panel of 892 double signature-tagged mutants was screened for virulence using an intranasal BALB/c mouse model of infection. A novel DNA tag microarray identified 33 mutants as being attenuated in spleens, while 6 were attenuated in both lungs and spleens. The transposon insertion sites in spleen-attenuated mutants revealed genes involved in several stages of capsular polysaccharide biosynthesis and DNA replication and repair, a putative oxidoreductase, ABC transporters, and a lipoprotein that may be important in intercellular spreading. The six mutants identified as missing in both lungs and spleens were found to have insertions in recA involved in the SOS response and DNA repair; putative auxotrophs of leucine, threonine, p-aminobenzoic acid, and a mutant with an insertion in aroB causing auxotrophy for aromatic compounds were also found. Murine challenge studies revealed partial protection in BALB/c mice vaccinated with the aroB mutant. The refined signature-tagged mutagenesis approach developed in this study was used to efficiently identify attenuating mutants from this highly pathogenic species and could be applied to other organisms.

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Melioidosis: Recrudescence Associated with Bronchogenic Carcinoma Twenty-six Years following Initial Geographic Exposure

Cited by 146 publications

References 9 publications

Outcomes of Patients with Melioidosis Treated with Cotrimoxazole Alone for Eradication Therapy

Outcomes of Patients with Melioidosis Treated with Cotrimoxazole Alone for Eradication Therapy

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

Development of Signature-Tagged Mutagenesis in Burkholderia pseudomallei To Identify Genes Important in Survival and Pathogenesis

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