Melatonin reduces oxidative stress in the erythrocytes of multiple sclerosis patients with secondary progressive clinical course

Miller, Elżbieta; Walczak, Anna; Majsterek, Ireneusz; Kędziora, J

doi:10.1016/j.jneuroim.2013.02.012

Cited by 62 publications

(57 citation statements)

References 32 publications

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“…Appropriate antioxidation intervention, via the inhibition or reduction of free radicals, offers protection against radiation-induced damage. Mel is a highly efficient free radical scavenger and a general antioxidant that has previously been demonstrated to protect DNA, lipids and proteins (32,34,35). Furthermore, antioxidant enzyme activities have been shown to exhibit circadian rhythms that correspond to Mel rhythmicity and the total antioxidant status (36).…”

Section: A B C Discussionmentioning

confidence: 99%

Neuroprotective effect of acute melatonin treatment on hippocampal neurons against irradiation by inhibition of caspase-3

Li¹,

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Neuronal cell apoptosis is associated with various factors that induce neurological damage, including radiation exposure. When administered prior to exposure to radiation, a protective agent may prevent cellular and molecular injury. The present study aimed to investigate whether melatonin exerts a neuroprotective effect by inhibiting the caspase cell death pathway. Male Sprague-Dawley rats were administered melatonin (100 mg/kg body weight) 30 min prior to radiation exposure in red light during the evening. In order to elucidate whether melatonin has a neuroprotective role, immunohistochemistry, terminal deoxynucleotidyl transferase dUTP nick-end labeling, Nissl staining, reverse transcription-quantitative polymerase chain reaction, reactive oxygen species analysis and western blotting were performed. At 24 h post-melatonin treatment, caspase-3 mRNA and protein expression levels were significantly decreased. These results demonstrated that melatonin may protect hippocampal neurons via the inhibition of caspase-3 when exposed to irradiation. Therefore, caspase-3 inhibition serves a neuroprotective and antioxidant role in the interventional treatment of melatonin. The results of the present study suggested that melatonin may have a potential therapeutic effect against irradiation; however, further studies are required in order to elucidate the underlying antioxidant mechanisms.

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Section: A B C Discussionmentioning

confidence: 99%

Neuroprotective effect of acute melatonin treatment on hippocampal neurons against irradiation by inhibition of caspase-3

Li¹,

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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“…Natalizumab is one of the most effective drugs at the early stage of MS. Melamud et al on the group of 13 MS patients demonstrated that the level of 6-sulphatoxy-melatonin (6-SMT) in urine is significantly lower but increased after interferon beta treatment concommitant with improved fatigue [65]. Our latest research on MS patients showed increased SOD and GPx activity and decreased lipid peroxidation in erythrocytes after 30 days of melatonin supplementation [66]. Table 1.…”

Section: Multiple Sclerosismentioning

confidence: 96%

Melatonin Redox Activity. Its Potential Clinical Applications in Neurodegenerative Disorders

Miller¹,

Morel²,

Saso³

et al. 2015

CTMC

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Neurodegeneration is the hallmark of many chronic progressive neurogical disorders characterized by specific clinical, morphological and biochemical features. Central nervous system is very sensitive to oxidative stress, which is considered as a key factor of neurodegenerative disorders. Therefore, many therapeutical strategies are focused on molecules with redox activity to re-establish the equilibrium between pro and antioxidants. Due to the fact that melatonin readily crosses the blood- brain-barrier, concomitant with its safety profile at the highest dosages makes this dietary supplement very useful in possible clinical application in neurodegeneration. Melatonin is currently marketed in several countries as a dietary supplement with no prescription. Clinical trials have shown different effectiveness of melatonin supplementation in several disorders, including neurodegenerative disorders. Melatonin has unique biochemical properties such as scavenging of hydroxyl, carbonate, alkoxyl, peroxyl and aryl cation radicals and stimulation of activities main antioxidative enzymes (glutathione peroxidase, superoxide dismutase etc.). Moreover, it can suppress nitric oxide synthase. The present paper highlighted the potential clinical role of melatonin in main neurodegenerative diseases including Alzheimer disease, Parkinson disease, amylotrophic lateral sclerosis and multiple sclerosis. Moreover, in this review the main molecular aspects of melatonin in brain cell protection and survival mechanisms were discussed. Therefore, melatonin is regarded as a potential therapeutical agent in clinical application in neurodegenerative disorders, but this findings needs to be confirmed by the larger, more well-designed clinical trials.

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“…Oxidative process may also be inhibited by NOS (41). It was reported that melatonin (10 mg daily/ 30 days) caused a statistically significant increase in antioxidative enzymes such as SOD and GPx and a decrease in malondialdehyde (MDA) in erythrocytes of SPMS patients (42). However, the relationship between the Expanded Disability Status Scale (EDSS), Gd + and SOD concentration in erythrocytes in clinically isolated syndrome (CIS) and RRMS patients is not clear and requires further investigation (42,43).…”

Section: Inflammatory Mediators and Antioxidantsmentioning

confidence: 99%

“…It was reported that melatonin (10 mg daily/ 30 days) caused a statistically significant increase in antioxidative enzymes such as SOD and GPx and a decrease in malondialdehyde (MDA) in erythrocytes of SPMS patients (42). However, the relationship between the Expanded Disability Status Scale (EDSS), Gd + and SOD concentration in erythrocytes in clinically isolated syndrome (CIS) and RRMS patients is not clear and requires further investigation (42,43). Melatonin also plays an important role in improving the antioxidant defense in MS through upregulation of sirtuin1 (SIRT1) and its target genes for MnSOD and CAT (44).…”

Section: Inflammatory Mediators and Antioxidantsmentioning

confidence: 99%

Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy

Adamczyk

Niedziela

Adamczyk-Sowa

2017

Multiple Sclerosis: Perspectives in Treatment and Pathogenesis

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Abstract:It is suspected that the development of multiple sclerosis (MS) can be affected by oxidative stress (OS). In the acute phase of the disease, OS is responsible for initiating inflammation, whereas in the chronic phase it sustains neurodegenerative process. Redox processes in MS are related to dysregulation of axonal bioenergetics, cerebral iron accumulation, mitochondrial dysfunction, impaired oxidant/antioxidant balance, and OS memory. This chapter gives an overview of the role of OS in MS.

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Melatonin reduces oxidative stress in the erythrocytes of multiple sclerosis patients with secondary progressive clinical course

Cited by 62 publications

References 32 publications

Neuroprotective effect of acute melatonin treatment on hippocampal neurons against irradiation by inhibition of caspase-3

Neuroprotective effect of acute melatonin treatment on hippocampal neurons against irradiation by inhibition of caspase-3

Melatonin Redox Activity. Its Potential Clinical Applications in Neurodegenerative Disorders

Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy

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